Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"cell competition"”.
-
Investigating the mechanisms of cell competition in mammals using in vitro systems
Cell competition leads to elimination of a viable cell population, by fitter cells. Despite over forty years of research, the molecular mechanisms of competition in mammals are poorly understood. During my PhD I have investigated the mechanisms of competition by exploring an established mammalian …
-
The mechanisms underlying mechanical cell competition and leader cell migration in mammalian epithelia
Cell competition is a form of cell-cell signalling that results in the elimination of less fit cells from a tissue by their fitter counterparts. I take advantage of an established in vitro model of cell competition using Madin-Darby canine kidney (MDCK) cells to shed insight into the molecular …
-
The nucleolar protein NOC1 is essential for ribosome biogenesis, and its reduction activates a novel MYC-p53 axis mediating nucleolar stress
Ribosome biogenesis is a complex cellular process that relies on the coordinated action of numerous nucleolar proteins and RNAs; a crucial step in this mechanism is represented by rRNA processing and maturation. Defects in this process result in a condition known as nucleolar stress, a field of …
-
Identifying a common cause of the loser cell status in Drosophila melanogaster.
Cell competition is the process whereby less fit cells termed “losers” are selectively eliminated from a tissue by their fitter neighbors – or “ winners.” This sacrifice of aberrant cells is thought to have evolved at the advent of multicellularity to enforce cell co-operativity and ensure the …
-
Flower Isoforms Increase Expression in Response to Cellular Stress and Modulate S100 Expression in Cutaneous Squamous Cell Carcinoma Cells
… most common cancer in humans, cutaneous squamous cell carcinoma (cSCC), affects more than 1 million patients a year in the United States. cSCC arise from keratinocytes of the epidermis or hair follicles. Current treatments are limited, especially for pre-cancerous lesions. Homeostasis and …
-
The Use of 2D and 3D Models to Study Competition in the Context of Barrett’s Oesophagus and Oesophageal Adenocarcinoma
… BO and OAC tissues, suggests a long history of cell competition which is yet to be understood. *Sawas et al*. in 2018 found that OAC patients with detectable BO tissue at the time of their cancer diagnosis were found to have increased survival compared to those without detectable BO. Although …
-
Telomeric Regulation of Chromosomal Instability In Colorectal Cancer
… tracing revealed that CIN increased neoplastic cell competition and clonal expansion through accelerated differentiation of neighboring stem cells, resulting in increased number of adenomas and decreased survival in CIN-high <em>Apc<sup>min</sup> </em>mice. Mechanistically, CIN represses EZH2 …
-
HPV E6 inhibits E6AP to regulate epithelial homeostasis by modulating keratinocyte differentiation commitment and YAP1 activation
… by modulating homeostasis of infected basal cell to ensure persistence. Using FUCCI and cell-cell competition assays, we established the role of two common viral targets of low-risk and high-risk E6 proteins, E6AP and NHERF1, on the key components of epithelial homeostasis: cell density, …
-
Deciphering tranSNPs: functional genetic variants shaping protein output and cancer-related phenotypes
… and their implications by exploring their cell line and cancer-type specificity, as well as their mechanistic insights focusing on the rs1053639 tranSNP (T/A) on DDIT4 3’UTR. This example demonstrated that a 3’UTR SNP can significantly affect mRNA localization, modification, and polysomal …
-
Regulation of Breast Cancer Initiation and Progression By 14-3-3Zeta
… reprogramming is a hallmark of cancer. Cancer cells elevate aerobic glycolysis to produce metabolic intermediates and reducing equivalents, thereby facilitating cellular adaptation to the adverse environment and sustaining fast proliferation. Interestingly, new evidence has emerged that …
-
Myc influences glutamine metabolism to induce autophagy in tumorigenesis
… and metabolic adaptation typical of tumour cells to support cell growth. One of the major players in this process is Myc, which can promote tumorigenesis by triggering a metabolic reprogramming that allows cells to produce macromolecules, by modulating glycolytic flux, glutaminolysis, …
-
Cell Polarity Regulates Organ Growth Through The Hippo Pathway
<p>Defects in apical-basal cell polarity and abnormal expression of cell polarity determinants are linked to human cancer. Loss of polarity is highly correlated with malignancy. In <em>Drosophila</em>, perturbation of apical-basal polarity, including overexpressing the apical determinant Crumbs, …
-
Lung Progenitor Cell Transplantation for Pulmonary Fibrosis and Ex Vivo Expansion of Patch-Forming EpCAM⁺CD31⁺ Cells
… the lung regenerative potential of simple lung cell transplantation in the well-established mouse model of naphthalene induced pulmonary injury, by either the entire lung cell population or only by the CD45- subpopulation. More recent FACS sorting experiments revealed that this curative …
-
The role of space in homeostasis and preneoplasia in stratified squamous epithelia
… in biological research is the dynamics of stem cells in squamous epithelia. Given that most common human cancers develop from epithelia, understanding the rules of cell fate decision in these systems is key to explaining not only healthy tissue growth and maintenance but also the processes of …
-
Cell Fate Decisions in the Early Mammalian Embryo
… from the totipotent zygote via two successive cell fate decisions in the appropriate sequence, position and proportion, to generate a blastocyst capable of implantation and further development. In mammals this process has long been thought to be regulative, with cell-cell interactions flexibly …
-
Alveolar stem cell dynamics and regulatory mechanisms in homeostasis and early oncogenesis
… of cancer-related mortality worldwide, yet the cellular dynamics and molecular mechanisms governing tumour initiation and progression remain elusive. Although alveolar type II (AT2) cells, which act as stem cells in the alveolar epithelium, have been identified as key cells of origin of LUAD, …
-
Functionality of mutant p53 in early tumorigenesis
… but it may uncover how the mutation primes a cell for aberrant activities. By modelling the heterozygous expression of p53R175H in unstressed, acute- and chronic-stress conditions (DNA damage induced senescence, DDIS), I have identified potential DN and GOF activities and the underlying …