Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 141 for “"cell communication"”.
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Multiplexing cell-cell communication
The engineering of advanced multicellular behaviors, such as the programmed growth of biofilms or tissues, requires cells to communicate multiple aspects of physiological information. Unfortunately, few cell-cell communication systems have been developed for synthetic biology. In this work, I …
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Cell-cell communication in three dimensional microenvironments
Cellular behavior is dependent on a variety of extracellular cues required for normal tissue function, wound healing, and activation of the immune system. Removed from their in vivo microenvironment and cultured in vitro, cells lose many environmental cues and that may result in abberant behavior, …
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Mechanisms of Eph/ephrin mediated cell-cell communication
… their membrane associated ephrin ligands mediate cell-cell repulsion to guide migrating cells and axons. A peculiarity of this signaling system is that both receptors and ligands can transduce signals into the cell resulting in a bidirectional signaling mode. An important step of ephrinB ligand …
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Study of cell-cell communication using 3D living cell microarrays
Cellular behavior is not dictated solely from within; it is also guided by a myriad of external cues. If cells are removed from their natural environment, apart from the microenvironment and social context they are accustomed to, it is difficult to study their behavior in any meaningful way. To …
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Computational analysis of cell-cell communication in the tumor microenvironment
Cell-cell communication between malignant, immune, and stromal cells influences many aspects of in vivo tumor biology, including tumorigenesis, tumor progression, and therapeutic resistance. As a result, targeting receptor-ligand interactions, for instance with immune check-point inhibitors, can …
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Using heterogeneous Graph Neural Networks(hGNN) to predict cell-cell communication
… diverse computational methodologies for modeling cellular interactions using single-cell RNA sequencing (scRNA-seq) data. We evaluate the performance of Graph Neural Networks (GNNs) both with and without gene-gene edges, Contrastive Learning, and Variational Autoencoders (VAEs) across multiple …
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Consequences and Limits of Cell-Cell Communication in Airway Immune Responses
… from deadly pneumonia to chronic allergies. Cell-cell communication is an important aspect of how airway immune responses are coordinated, yet it is not fully known which airway cell types send intercellular signals, under what circumstances, and what the consequences of those intercellular …
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A nucleic acid-based bacterial message export system for cell-to-cell communication
Communication within natural systems of eukaryotes and prokaryotes typically entails message transmission between and among cells via small-molecule messengers being funneled from the sender to the receiver cell. Nucleic acids are rarely used as extracellular messengers due to their labile nature …
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INVESTIGATING THE ROLE OF DEFECTIVE CELL TO CELL COMMUNICATION MECHANISMS IN RETT SYNDROME PATHOGENESIS
Rett syndrome (RTT) is a devastating neurodevelopmental disorder representing the main cause of severe intellectual disability in girls worldwide. Over 95% of individuals suffering from a classic form of RTT carry sporadic mutations in the X-linked MECP2 gene, encoding for the methyl-GpC-binding …
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Exploration of Platelet and Mast Cell Communication: A Study of Membrane Lipids, Asthma, and Inflammation
… exposure, and inflammatory diseases impact cell communication. It explores the use of different cell models, specifically platelets and mast cells, to understand how disease states can impact cellular function. Throughout the thesis, a variety of analytical techniques including …
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Genomically encoded logic gates and cell-cell communication devices for the implementation of a cryptographic hashing algorithm in living cells
Cell-cell communicaon can be harnessed to distribute tasks across different cells. Applied to biocomputaon, communicaon enables cell populaons to carry out operaons too complex to be performed in a single cell. Doing so in a predictable manner requires well characterized genec parts that can signal …
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The Role of Cell Communication and 3D Cell-Matrix Environment in a Stem Cell-Based Tissue Engineering Strategy for Bone Repair
The use of stem cells for the repair of bone and cartilage is a primary research interest in modern tissue engineering strategies. The goal of this doctoral thesis was to investigate the role of cell communication and mechanical stimulation in a 3D tissue engineered construct, and to determine …
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Communication at the Cellular Level: Discovery and Application
Cell-cell communication is essential to the functioning of all multicellular organisms, and understanding these critical processes can help solve current biomedical problems. As a demonstration of the utility of this approach, existing knowledge of the interactions between B cells and T cells in …
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Identifying the molecular components that matter: a statistical modelling approach to linking functional genomics data to cell physiology
… are predictive of the physiological state of a cell or tissue. In this thesis, a truly multivariate variable selection framework using diverse functional genomics data has been developed, characterized, and tested. This framework has also been used to prove that it is possible to predict the …
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The Role of Gap Junctions in Congenital Diseases of the Heart
… several protein kinases that regulate myocardial cell-cell coupling. We hypothesized that mutations altering sites critical to this regulation would lead to functional or developmental abnormalities of the heart.</p> <p><strong>Methods.</strong> <em>Connexin43</em> DNA from 25 normal subjects and …
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Mechanistic studies on the role of extracellular vesicles in the tumor microenvironment
The transition from normal into malignant cells with acquired uncontrolled growth is a process where cancer cells viciously develop adaptive strategies to overcome microenvironmental and metabolic stress. Hypoxia, or deficient oxygen supply, is a common feature of the expanding tumor which alters …
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Feedback Regulation of Human Hematopoietic Stem Cell Fate
Hematopoietic stem cell (HSC) fate decisions at least in part determine cellular composition of the hematopoietic system. It is known that differentiated blood cells produce ligands that act on HSCs to influence HSC fate. However, fundamentals underlying the feedback regulation of HSC fate are …
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Uncertainty and Generality of Transfer Learning Models in Predicting Signaling History
Proper cell-cell communication is essential for multicellular development, from embryogenesis to stem cell differentiation. To map these networks, we developed IRIS (Intracellular Response to Infer Signaling state), a semi-supervised deep learning method that fits conditional variational …
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