Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"cell commitment"”.
-
MiRNA influences in mesenchymal stem cell commitment to neuroblast lineage development
Mesenchymal Stem Cells (MSCs) are multipotent stromal cells that can self-renew and differentiate into cells from the mesodermal cell lineage. Under specific conditions, MSCs are known to transdifferentiate into the neuronal cell lineage. The aim of this study was to investigate if specific …
-
A phagocyte-specific Irf8 gene enhancer establishes early conventional dendritic cell commitment
… the phagocyte lineages are a very heterogeneous cell compartment with specialized functions in innate immunity and induction of adaptive immune responses. Their generation from a common precursor must be tightly controlled. Interference within lineage formation programs for example by mutation or …
-
Functions of Novel Ligand-independent Flt3 Alleles and RANKL in Promoting Dissemination of Murine B-Cell Leukemias to the Central Nervous System
Survival rates for pediatric B-cell acute lymphoblastic leukemia (B-ALL) have improved dramatically, but outcomes for the 15% who relapse and for adults with B-ALL remain poor. Up to 40% of pediatric B-ALL patients require central nervous system (CNS) prophylaxis that causes significant …
-
ELUCIDATING REGULATORY NETWORKS PROMOTING B-CELL DEVELOPMENT
B-cells are an essential part of our adaptive immune system. A network of transcription factors together with external signals facilitate the gradual developmental progression from progenitor cells towards the B-cell fate. Several key factors participating in this network have been identified. …
-
Oocyte differentiation is genetically dissociable from the meiotic program in mice
… program by which a gametogenesis-competent germ cell becomes a fertilization-competent egg. During oogenesis, growth and differentiation of oocytes are closely coordinated with initiation and progression through meiosis. In mammals, the timing of meiotic initiation is sexually dimorphic, with …
-
CROSSTALK BETWEEN PRC1 AND PRC2 IN INTESTINAL LINEAGE COMMITMENT AND CELL IDENTITY
… Complexes 1 and 2 (PRC1 and PRC2) control cell identity by establishing facultative heterochromatin repressive domains at common sets of target genes, from the early stages of development to adulthood. How they functionally preserve transcriptional silencing has been deeply explored in …