Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 135 for “"cell apoptosis"”.
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FOXO3a in Vascular Smooth Muscle Cell Apoptosis
… increased activation in vascular smooth muscle cells (VSMCs) of advanced atherosclerotic plaques, specifically within the intimal layer. Since VSMC apoptosis plays a crucial role in the pathophysiology of atherosclerosis, we investigated the mechanisms underlying FOXO3a-mediated cell death in …
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Role of CD47 In Red Cell Apoptosis (Eryptosis)
… superfamily (IgSF). It possesses a large extracellular N-terminal IgV like domain. CD47 acts as a ‘do not eat me’ signal and consequently as a marker of self. Moreover, CD47 is reported to be upregulated in cancer cells allowing them to escape immune surveillance by binding to SIRP alpha on …
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ADP regulation of insulin secretion and beta-cell apoptosis
… were to investigate the effects of extracellular purines on insulin secretion, and apoptosis in mouse pancreatic islets and β-cells; to examine if high glucose and free fatty acids induces β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate the …
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RNA interference targeting Glucose-Regulated-Protein 78 induces HepG2 cell Apoptosis
… mutations resulting in chronic, inappropriate cell proliferation. Many current cancer therapies lack specificity towards tumor tissues, ultimately leading to adverse side effects and limited clinical efficacy. Recently, selective cancer cell therapy has examined a well-characterized cell …
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The mechanism of glucocorticoid induced murine thymocyte and peripheral T cell apoptosis
Glucocordicoide sind kleine lipophile Verbindungen, die viele biologische Effekte verursachen, wenn sie an den intrazellulären Glukokortikoidrezeptor (GR) binden. Dieser wandert wiederum in den Nucleus, um dort direkt oder indirekt die Transkription der Gene zu regulieren. Glukokortikoide sind der …
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Inhibition of Deubiquitinase Activity and Ubiquitination of Jak2 Blocks Cytokine Signaling and Induces Tumor Cell Apoptosis
The Jak-stat pathway is critical for cellular proliferation and is commonly found to be deregulated in many solid tumors as well as hematological malignancies. Such findings have spurred the development of novel therapeutic agents that specifically inhibit Jak2 kinase, thereby suppressing tumor …
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Role of oocyte-secreted factors in prevention of cumulus cell apoptosis and enhancement of oocyte developmental competence.
… factors, OSFs) regulate a broad range of cumulus cell functions. The capacity of oocytes to regulate their own microenvironment by OSFs may in turn contribute to oocyte developmental competence. The aim of this thesis was to examine whether cumulus cells exhibit a low incidence of apoptosis due to …
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Adaptation of Three Different Apoptotic Methods in Equine Bronchoalveolar Cells and Comparison of Bronchoalveolar Lavage Cell Apoptosis in Normal and COPD Affected Horses Before and After Dexamethasone Administration
Recent studies suggest that lymphocyte apoptosis serves to regulate pulmonary inflammation. Equine COPD, an allergic disease of the lower airway, is likely due to dysregulation of the pulmonary immune response. In this study, the hypothesis tested was COPD affected horses would have less apoptotic …
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Repurposing Alzheimer’s disease medications in a drug combination for the study of the crosstalk between cell apoptosis and autophagy in the modulation of cell death in chronic myeloid leukaemia
… this research was to study the crosstalk between cell apoptosis and autophagy in the modulation of cell death and to determine if AD medications, singly and in combination with a CML drug, have the potential to be repurposed for the treatment of CML . HEK293T (cell model of AD) and K-562 (cell …
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Microrna 21 targets B Cell Lymphoma 2 (Bcl2) Mrna to increase beta cell apoptosis and exosomal Microrna 21 could serve as a biomarker of developing Type 1 Diabetes Mellitus
The role of beta cell miR-21 in Type 1 Diabetes (T1D) pathophysiology has been controversial. Here, we sought to define the context of beta cell miR-21 upregulation in T1D and the phenotype of beta cell miR-21 overexpression through target identification. Furthermore, we sought to identify whether …
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Expression of perforin and granzyme variants in adult rat testes after ethylene dimethane sulfonate (EDS)-induced testosterone depletion
… and testosterone withdrawal results in germ cell apoptosis. However, the mechanism for germ cell apoptosis is unknown. In testes, mature Leydig cells produce testosterone. Using ethane dimethane sulfonate (EDS), a Leydig cell-specific toxicant, to deplete testosterone, we investigated the …
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The role of ceramides in cigarette smoke-induced alveolar cell death
… structures, in part attributed to alveolar cell apoptosis. The mechanism by which cigarette smoke (CS) induces alveolar cell apoptosis is not known. We hypothesized that ceramides are induced by CS via specific enzymatic pathways that can be manipulated to reduce lung cell apoptosis. CS …
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Cellular Mechanism of High Glucose/Palmitate-induced INS-1 Beta Cell Death
… free fatty acids (FFAs) induces pancreatic beta cell dysfunction and death, which may contribute to the development of type 2 diabetes. A deficiency of insulin through loss of beta cell mass, and subsequent impaired compensation against insulin resistance is believed to be a pathogenic cause of …
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Regulation of autophagy, endoplasmic reticulum and unfolded protein response by glucocorticoids in physiology and disease
… To understand better how GC-resistant leukemic cells respond to Dex treatment, combination treatment of Dexamethasone with Chloroquine (CLQ), Thapsigargin (TG), Rotenone (ROT) and Bortezomib (BTZ) were used to investigate the role of autophagy, endoplasmic reticulum stress (ER stress) and …
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The mechanism of T cell dysfunction induced by Diethylstilbestrol
… the mechanism by which DES is able to alter T cells and thus theimmune system. First, we studied the effect of DES on mature T cells by using the T cellleukemia cell line, Jurkat. We found that DES treatment reduced cell viability andincreased apoptosis. Additionally, apoptosis was found to …
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Biological and computational tools for systems biology : application to Fas signaling pathways in T cells
… have begun to take a more global view into cell function, approaching its study in a more systematic manner than previously possible. This thesis develops three new tools to perform systems biology studies of cell death in T cells: A modeling program, JDesigner; high throughput T cell …
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