Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"cell alignment"”.
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Knockdown of Heparan Sulfate Via NDST1 knockout Does Not Inhibit Mouse Aortic Endothelial Cell Alignment In-Vivo
… and dysfunction to the endothelium. Endothelial cells (ECs) under sustained laminar flow align in the direction of flow; however, under disturbed flow conditions, ECs sustain damage to their glycocalyx (GCX) which results in unaligned and rounder cells. An investigation into the role of NDST1 …
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Elongated fascicle-inspired 3D tissues consisting of high-density, aligned, optogenetically excitable muscle tissue using sacrificial outer molding
… morphology. Each fascicle has a) elongated cells highly aligned with the length of the construct, b) a high volumetric cell density, and c) a high length-to-width ratio with a diameter small enough to facilitate perfusion. Fiber-like fascicles are important building blocks for forming those …
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Cell migration and alignment on mechanically controlled environment
… effect of mechanically controlled environment on cell migration and alignment in vitro. Understanding such behaviors are necessary to study wound healing of life, metastatic of cancer cells, tissue engineering, and regenerative medicines. First study is a cell migration behavior on stiffness …
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Shape Memory Polymers as 2D Substrates and 3D Scaffolds for the Study of Cell Mechanobiology and Tissue Engineering
… is a promising, fast-growing field that combines cells, signals, and scaffolds to regenerate damaged tissues. To develop new, functional, engineered tissues, it is becoming increasingly important to understand how cell-material interactions affect the cell mechanobiological response. As a result, …
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Active Vertex Model of Epithelial Monolayer Mechanics
An Active Vertex Model (AVM) for cell-resolution studies of the mechanics of confluent epithelial tissues consisting of tens of thousands of cells, with a level of detail inaccessible to similar methods is presented. The AVM combines the Vertex Model for confluent epithelial tissues with active …
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Collagen-Glycosaminoglycan Scaffold Systems to Assess HL-1 Cardiomyocyte Beating and Alignment
… development of scaffold systems to examine the alignment and beating potential of HL-1 cardiomyoctyes in a 3D environment. Collagen-glycosaminoglycan scaffolds have been used extensively to probe the behavior of mature cells in vitro, but have not yet been designed for cardiac applications. In …
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Cell Migration and Morphogenesis during Formation and Repair of Zebrafish Skeletal Muscle
… to somite shape morphogenesis. In vivo cell tracking revealed that cellular dynamics during somite morphogenesis constitute a potential force, capable of driving somite shape changes. Tracked anterior border cells (abc) were observed migrating to the lateral somite surface were they are …
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Analyzing Interactions Between Cells And Extracellular Matrix By Atomic Force Microscopy
Interactions of cells with the extracellular matrix (ECM) have important roles in various physiological and pathological processes, including tissue morphogenesis during embryonic development, wound healing and tumor invasion. Although most of the proteins involved in cell-ECM interactions have …
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Fundamental study of pulse electric field effects on hela cell cultured over extracellular matrix protein micro-patterned surface
Electroporation (EP) is a method of controlling cell function by using pulses of electrical fields to create pores through cell membrane and causes other substance around it to be absorbed into the cell. This method has led to a variety of medical applications, particularly in cell studies. In this …
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A MULTISCALE APPROACH TO STEM CELL-BASED CHONDROGENESIS FOR CARTILAGE REPAIR
… and soft-lithography. Human mesenchymal stem cells (hMSCs) were selectively seeded in these channels. The chondrogenic potential of hMSCs seeded in these channels was investigated. We demonstrate selective seeding of viable hMSCs within the channels. hMSC aligned and produced mature collagen …
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Characterization of the cardiogenesis of embryonic stem cells
… the leading cause of mortality worldwide. Stem cell therapy, aimed to restore contractility and proper vasculature, has gained considerable attention as an attractive therapeutic option. However, proper cell differentiation, survival and integration in an infarcted zone remain elusive. This …
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Effect of Electrospun Mesh Diameter, Mesh Alignment, and Mechanical Stretch on Bone Marrow Stromal Cells for Ligament Tissue Engineering
… three steps: seeding bone marrow stromal cells (BMSCs) onto electrospun scaffolds, processing them into cords that allow cell infiltration, and conditioning them with uniaxial cyclic stretch. These steps were addressed in three complimentary studies to establish new methods to engineer a …
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Studying the glial cell response to biomaterials and surface topography for improving the neural electrode interface
… that surface topography modifications can alter cell alignment, adhesion, proliferation, migration, and gene expression (Agnew et al., 1983; Cogan et al., 2005; Cogan et al., 2006; Merrill et al., 2005). Thus, the goals of the presented work are to study the cellular response to biomaterials used …
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Shear Stress-Mediated Tumor-Endothelial Cross Talk Regulates the Angiogenic Potential of Breast Tumors In Vitro
… interaction between tumor and endothelial cells to mediate angiogenesis, and the role of flow shear stress on this process, may offer insight into the design of improved therapeutic strategies to control vascularized tumors. Instrumental to this is the development of physiologically …
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Homeostatic mechanics for a synthetic cell: predictions on substrate anisotropies and cell-cell interactions
… one or more biological processes, which in cells are known to be highly coupled. This added complexity limits the control over the biocompatibility and biofunctionality of the designed tissues. Amongst the many degrees of freedom in question, substrate topological and mechanical properties, …
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Development of cardiac patches using medium chain length polyhydroxyalkanoates for cardiac tissue engineering
… by growing human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CM) on them. The cells were found to be viable and healthy with comparable beating rates and calcium transients to that measured on gelatin which was used as the positive control. The cell alignment quantification …
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Roles Of Neuregulin1 In Neuromuscular Junction Development
… target muscles, and peri-synaptic glial cells, and thus requires reciprocal signals derived from every cell type. Neuregulin1s (NRG1s) are a family of predominantly neuronal growth and differentiation factors that are important for many aspects of nervous system development. In this …
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Additive Manufacturing of Functional Materials for Biomedical Devices
… and biomedical surfaces for the regulation of cell growth. Anisotropic, self-assembling, and self-reinforcement hierarchical liquid crystal polymer (LCP) are 3D printed with the form of fibres into macroscopic non-linear strain-hardening metamaterials to fabricate lightweight and flexible ankle …
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Effects of micro- and nano-scale surface geometry on behaviors of live cells and liquid droplets
… surface geometry also affects biological cells by altering their mechanical environment. In the case of cell mechanics we generally lack even a flawed model for describing the observed behavior, so we seek to identify parameters that might simplify these cellular systems. One method that …
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Homeostatic mechanics framework for modelling interactions of cells with the microenvironment
Spreading and locomotion enable the cells to explore their microenvironments during the interphase period of the cell cycle (24-48 hours after cell seeding and prior to cell division). The morphologies adopted by cells in this period dictate orientational ordering, direction and speed of migration, …
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