Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"cell adhesion proteins"”.
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The Role of the YXXΦ Motif in CD82 Trafficking and Function
… suppressor. Tetraspanins are membrane spanning proteins that play critical roles in diverse biological and pathological processes, e.g., the regulation of cancer metastasis. CD82 is ubiquitously expressed in various types of tissues, but its expression becomes down-regulated or lost in a …
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CD151 Reinforces Vascular Stability by Balancing Endothelial Cell Adhesion and Cytoskeletal Tension
… CD151 is highly expressed in endothelial cells and regulates pathological angiogenesis. However, the mechanism by which CD151 promotes vascular morphogenesis and whether CD151 engages other vascular functions are unclear. We observed that CD151 is required for the maintenance of …
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Analysis of the effects of BrdU on DLKP human lung cancer cells by two-dimensional difference gel electrophoresis and mass spectrometry
… analogue that incorporates into DNA of dividing cells during the S-phase of the cell cycle. Previous work in laboratories reported that treatment with lOyM BrdU in the human lung carcinoma cell line (DLKP) resulted in increased expression of the cytoskeletal proteins Keratin 8 and 18 and the cell …
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Design of multi-functional hydrogel for cell therapies
… investigated as encapsulation devices for cell transplantation therapies, as they provide structural stability and protection against harsh chemical and mechanical stimuli, and host immune system. In addition, chemical moieties, mechanical stiffness, and minerals presented in hydrogels act …
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Cell culture platforms with cell-cell adhesive ligands for biomedical applications
Cell behavior is regulated by a number of different mechanical and chemical cues within the extracellular microenvironment, including the surrounding matrix and neighboring cells. Although biomaterials have been engineered to present several adhesion molecules that mimic cell-extracellular matrix …
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Transcriptional Governance of Hair Follicle Stem Cell Quiescence and Niche Maintenance in Long-Term Tissue Regeneration
<p>Adult stem cells are endowed with the remarkable ability to maintain, regenerate and repair tissues throughout the lifetime of the organism. Whether parsimonious utilization of adult stem cells is necessary to preserve their long-term potential has not been fully explored. I investigated this …
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Proteomics based analysis of interactions between CEA cell adhesion molecule 1 (CEACAM1) and intracellular proteins in transfected tumor cells
CEA Cell Adhesion Molecule 1 (CEACAM1), a type 1 transmembrane protein belonging to the CEA gene family, is alternatively spliced to produce four major isoforms with a long (CEACAM1-L) or a short cytoplasmic domain (CEACAM1-S). Immunoprecipitations using the murine adenocarcinoma MC38 cell line …
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The role of PTPRF and PTPRK in regulating cell adhesion
… phosphatases (RPTPs) are critical regulators of cell signalling and communication, controlling cellular phospho-tyrosine (pTyr) levels and playing essential roles in tissue morphogenesis. Plasma membrane RPTPs are well positioned to sense external environmental cues, such as cell-cell contact, …
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Insights into protein function from evolutionary and conformational dynamics
… concerns the biophysics of cadherin-mediated cell sorting observed in developing solid tissue. We investigated the evolutionary dynamics of the cadherin superfamily of cell-cell adhesion proteins to infer a structural basis for their paradoxical mixture of pairwise binding specificity and …
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Mechanical regulation of cell-cell junctions
Cadherins are cell-cell adhesion proteins that mediate cell recognition, segregation, and signaling in many tissues. Recent findings demonstrated that type I classical cadherin complexes are mechanosensitive. Mechanical forces in the tissue environment play a profound role in the growth, …
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Regulation of cadherin adhesion at intercellular junctions
Adhesion proteins maintain cell-cell interactions, which are critical for tissue formation and the hierarchical organization of all multicellular organisms, and among them, cadherins are the major transmembrane cell-cell adhesion proteins in all vertebrate tissues. Regulation of cadherin mediated …
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Investigating the TrkB Interactome during Development and in Neurodegeneration
… of these receptors help them to define which proteins are locally synthesized in response to stimulation. BDNF likewise regulates the local nascent proteome with high spatiotemporal resolution via TrkB activation. While there is extensive data on expression level, trafficking and signalling of …
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Role of extracellular environment in mechanical properties of human cardiac fibroblasts and myofibroblasts
… loss. Cardiac fibroblast and myofibroblast cells are integral in the remodelling of injured tissue and are the most anticipated therapeutic target for cardiac fibrosis. To date, there is no anti-fibrotic therapy, which we argue, is due to the lack of knowledge on the functionality of the …
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Lokalisierung und Charakterisierung von Zellkontaktproteinen im olfaktorischen Epithel
Ziel der vorliegenden Arbeit war die Lokalisierung und Charakterisierung von Zellkontaktproteinen im olfaktorischen Epithel. Hierzu wurde die Riechschleimhaut der Ratte für immunhistochemische, elektronenmikroskopische und biochemische Experimente aufbereitet. Nachdem das Erscheinungsbild der …