Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"cell adhesion molecules"”.
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Liver Cell Adhesion Molecules in Embryonic Development
<p>Cell-cell adhesion is one of the essential processes for normal embryogenesis. The isolation and characterization of the neural cell adhesion molecule, N-CAM, provided the first substantial opportunity to study this process at a molecular level. Moreover, studies of N-CAM expression in embryos …
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Differential Expression of Cell Adhesion Molecules by Neuronal Injury
Cell adhesion molecules(CAMs) are expressed in glial cells and neurons play critical roles in development and maintenance of nervous system. CAMs are reported that may be key molecular determinants in the response of the nervous system to injury. Therefore we are thought to that the expression of …
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Homophilic and Heterophilic Interactions Among Cadherin Cell Adhesion Molecules
… over heterophilic binding that would explain the cell sorting behavior.
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Plasticity in mice nociceptive spinal circuits -role of cell adhesion molecules.
… have to deal with complex issues related to intercellular communication, e.g. plasticity in neuronal networks. To provide a basis for such studies, the present thesis compares basic features of the nociceptive spinal systems including the organization of nociceptive withdrawal reflexes (NWR), …
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Interaction between cell adhesion molecules and stress hormones following different intensities of cycling exercise in obese males.
… (NE), and cortisol (COR)] and soluble cell adhesion molecules [soluble intercellular adhesion molecule 1(sICAM-1), soluble vascular cell adhesion molecule 1(sVCAM-1), and soluble endothelial selectin (sE-selectin)] over 24 hours following different intensities of exercise in obese men. …
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A Phenotypic And Genetic Characterization Of The Cell Adhesion Molecules Echinoid And Friend-Of-Echinoid In The Directed Cell Movements Of Ommatidial Rotation During Drosophila Eye Development.
Correct development of multicellular organisms relies on the precise patterning of cells, which must respond to and interpret specific cues that instruct the cells to differentiate and often undergo directed cell movements and rearrangements to give rise to functional tissues and organs. …
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Plasma membrane calcium ATPase 4 (PMCA4) and inflammation of the aortic endothelium
… of tissue injury. The endothelial expression of cell adhesion molecules, namely the selectin family, mediates the initial adhesive interactions between leukocytes and the endothelium. Immune cell infiltration is often involved in the initiation and progression of several vascular diseases, …
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Role of ICAM-1, a cell adhesion molecule, in morphological changes of BV2 microglial cell
Microglial cells, the major immune effector cells in the central nervous system, are activated in various brain injuries. Lipopolysaccharide (LPS), found in the outer membrane of Gram-negative bacteria, one of the major activator of microglia induces morphological changes and activation of the …
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CYTOKINE CONTROL OF GLIOMA ADHESION AND MIGRATION
… of surgical resection, and because GBM cells are resistant to radiation and chemotherapy. This sad dismal prognosis for patients with GBM emphasizes the need for greater understand of the fundamental biology of the disease.</p> <p>Invasion is one of the major causes of treatment failure …
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Biophysical and Structural Studies of CNTNAP2
At synapses, cell adhesion molecules provide connection between the presynaptic and postsynaptic membranes through homophilic and heterophilic interactions promoting synapse development, function, and plasticity. The synaptic adhesion molecules contactin 2 (CNTN2), and contactin associated …
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Structural and Dynamic Proximal Proteomic Analysis of TRPV2 Ion Channel Activation
… regulated pathway which mediates every vital cellular function through the propagation of localized calcium flux. Transient receptor potential vanilloid type 2 (TRPV2) ion channels are calcium-permeable, tetrameric ion channels with implications in several cellular processes such as immune …
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Characterization of a Novel Prostate Tumor-Associated Antigen
… HNK-1 carbohydrate epitope may be involved in cell adhesion and that it is a component of several characterized adhesion proteins. TURP-27 was found to bind at least three of these adhesion proteins: neural cell adhesion molecules (N-CAM), myelin-associated glycoprotein (MAG) and a second …
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Functional genomic and transcriptomic tools for spatial and dynamic phenotypes
Biology is driven by complex cellular processes that require precise regulation in time and in space. However, the genetic and molecular factors underlying these behaviors are difficult to study in their native contexts and, as a result, are often not well understood. Although next-generation …
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Immunological responses following surgery in ulcerative colitis
The role of serum autoantibodies, soluble adhesion molecules, plasma and mucosal cytokines were studied following surgery for ulcerative colitis (UC). A high prevalence of ANCA was found in UC but not in Crohn’s disease. ANCA positive UC sera were found to recognise a variety of antigens, namely …
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Design of multi-functional hydrogel for cell therapies
… investigated as encapsulation devices for cell transplantation therapies, as they provide structural stability and protection against harsh chemical and mechanical stimuli, and host immune system. In addition, chemical moieties, mechanical stiffness, and minerals presented in hydrogels act …
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Structural Basis of the Tensile Strength of Protein Complexes Mediating Cell Adhesion
… explores the behaviour of adhesive complexes of cell adhesion molecules undergoing forced detachment. Molecular-forces measurements combined with Steered Molecular Dynamic (SMD) simulations were used to investigate the mechanical response of the CD2 C58 and hemophilic C-cadherin bonds. The …
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Cadherin recognition and specificity
Cadherins are calcium dependent cell adhesion molecules. The interaction between cadherin molecules is important in establishing cell polarity, tissue identity and tissue boundary. This study focused on the mechanism of cadherin mediated cell-cell interaction and binding specificity. First, the …
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N-linked glycosylation is fundamentally linked to the surface expression of neuroligins
… modification, decorating secreted and cell-surface transmembrane proteins as they are trafficked along the secretory pathway. While well-characterized in most tissues, non-canonical N-glycan diversification has been reported to occur in the central nervous system. Chapter 2 of this …
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Molecular Pathogenesis of Autism: A Role for Neurexin and Neuroligin
… for each other, are two families of synaptic cell-adhesion molecules that have been linked to ASD pathogenesis. I found that three different mouse models for ASDs, the neurexin-1α deletion, the neuroligin-3 (NL3) R451C mutation, and the NL3 R704C mutation all aberrantly alter synaptic …
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Obscurin Mediates Ankyrin Complex Formation In The Heart
… receptors, ion channels, transporters, signaling molecules, cell adhesion molecules, and contractile proteins are crucial to cardiac function. Interactions between adaptor proteins such as ankyrins and cytoskeletal proteins such as obscurin play a pivotal role in organizing these functional …
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