Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 349 for “"cell activation"”.
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RNA Dynamics in T Cell Activation
<p>Eukaryotic cells employ multiple posttranscriptional mechanisms to fine tune gene expression programs in response to external signals. Regulation of messenger RNA and microRNA by RNA-binding proteins is critical to the control of this process. Hence, disruptions of RNA regulatory processes …
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Multi-scale models of T cell activation
… underlying the adaptive immune response: the activation of T cells. The specific objectives are: 1) develop efficient and versatile computational frameworks to study multi-scale biological systems in silico; 2) obtain mechanistic insights into how T cells are triggered in vivo. The first …
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Molecular Control of Tooth Mesenchymal Stem Cell Activation
… model for studying molecular mechanisms of stem cell (SC) fate determination. While the epithelial SCs are well studied within this model, the identification and characterisation of a mesenchymal SC (MSC) population has yet to be defined. Aims This study aims to identify the molecular signatures …
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Signals for B cell activation in antibody response
… are the sites where V-gene hypermutation and B cell selection are taking place. Testing specificity and affinity of GC B cell receptor by interaction with antigen on follicular dendritic cells (FDCs) may be an important selection process to select high affinity B cell clone. As antigen on FDC is …
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Influence of Anti-CD44 on Murine B Cell Activation
Lymphocyte activation and trafficking are indispensable to the immune system. CD44, an adhesion molecule, plays important roles in T cell activation, lymphocyte homing/trafficking, and tumor metastasis. Although the functions of CD44 have been shown in T cells and other leukocytes, little is known …
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Decoding CD4+ T cell activation by multi-modal phenotyping
The activation of CD4+ T cells is strongly implicated in the biology of immune-mediated diseases, yet the molecular and functional mechanisms governing this process remain incompletely understood. With the explosion of profiling and functional genomic methods in the last decade, it is now feasible …
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Rare event simulation for probabilistic models of T-cell activation
… is critical for our survival. One of the major cell types involved in these decisions are the so called T-cells, which are specialized white blood cells with a detection mechanism that is not fully explained until now. There is not a one to one specificity between T-cells and antigens. T-cells …
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Cd4 T Cell Activation And Ox40 Agonist Immunotherapy In Tuberculosis
… (Mtb) infection millions of effector T cells traffic to the lungs, but relatively few find antigen and become activated. We used an antigen receptor reporter mouse (Nur77-GFP) infected with Mtb to distinguish recently activated CD4 T cells from others in the lungs. Recently activated …
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The Function of LAT in T Cell Activation and Autoimmunity
<p>LAT (linker for activation of T cells) is an important transmembrane adaptor protein in TCR-mediated signaling. Upon TCR engagement, LAT associates with multiple proteins which allows for the activation of downstream signaling pathways. The interaction between LAT with phospholipase C …
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Spatial Dynamics and the Mechanoresponse in CD4+ T Cell Activation
The activation of naïve CD4+ T cells by antigen presenting cells is a critical step in the response of the immune system to foreign pathogens and in its acclimation to host tissues. Activation of naïve T cells proceeds through TCR engagement and is further augmented by CD28 costimulation: ensuring …
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Redox Regulation of T cell Activation and Function During Viral Infection
… of reactive oxygen intermediates (ROI) during T cell activation and the importance of their regulation during an immune response. ROI generated in response to receptor stimulation play an important role in mediating cellular responses. We have examined the importance of reversible cysteine …
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The role of the adapter protein TSAd in T cell activation
Introduction: T cells are a part of the adaptive immune system, which is designed to attack pathogens in the body. T cells recognize antigen presented by HLA molecules on the surface of antigen presenting cells (APC) through their T cell receptor. Conjugation formation between T cells and APC turns …
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Biomarkers of Optic Nerve Head Glial Cell Activation Following Biomechanical Insult
… irreversible apoptotic death of retinal ganglion cells, a unique optic nerve neuropathy resulting in loss of vision. Increased intra-ocular pressure is known to be a leading risk-factor for glaucoma, and lowering IOP is currently the only evidence based method for the clinical management of the …
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IDENTIFICATION OF CDC7 AS A NEW REGULATOR OF T CELL ACTIVATION
… was screened for their effects on suppressing activation in several T cell populations. The screening assay was able to identify inhibitors of canonical kinases of TCR signalling and kinases that were not previously characterised in TCR signalling. Through the screening assay, a dual inhibitor …
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The Initial Events of T-Cell Activation in Realistic Model Systems
T cells are part of the cellular component of the adaptive immune system and specifically recognise foreign antigens in the body. They use their membrane-bound T-cell receptor (TCR) to bind small peptide antigens presented within the major histocompatibility complex (pMHC) on the surface of antigen …
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The effects of nitrosoureas on Thymocyte differentiation and T cell activation
… an increase in the percentage of CD4⁻ CD8⁻ T cells and a decrease in the percentage of CD4⁺CD8⁺ T cells in the thymus. In addition, such treatment also caused an increase in the percentage of CD4⁺ T cells without significantly affecting the CD8⁺ T cells in the thymus. However, when total …
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Alternate pathways of cytotoxic T lymphocyte and natural killer cell activation
… transmembrane glycoprotein found on a variety of cells including those of myeloid and lymphoid origin. CD44 is highly conserved among various species and is involved in the homing of lymphocytes and monocytes to lymph nodes, Peyer's patches, and sites of inflammation. In the present study, we …
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Polysaccharide-based nanostructures for growth factor delivery and mesenchymal stem cell activation
Mesenchymal stem cells (MSCs) are very promising in tissue engineering and regenerative medicine because of their ability to differentiate into different type of cells including bone and cartilage. MSCs differentiation can be modulated using both chemical (i.e. proteins) and physical cues (ie. …
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