Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 89 for “"cd11b"”.
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The relevance of CD11b and CD18 in the pathogenesis and treatment of psoriasis
Contains fulltext : mmubn000001_253402859.pdf (Publisher’s version ) (Open Access)
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The ontogeny and function of intestinal dendritic cells
… distinct subsets based on their expression of CD11b. In paper II, we assess the ontogeny and in vivo functions of intestinal CD103+CD11b- and CD103+CD11b+ intestinal cDCs. cDC subset development depends on distinct transcription factors (TFs) and while the development of CD103+CD11b- cDC …
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DISSECTING THE ROLES OF DISTINCT DENDRITIC CELL SUBSETS IN THE IMMUNE RESPONSE TO THE INTRACELLULAR BACTERIAL PATHOGEN, LISTERIA MONOCYTOGENES
… dependent on the TLR adapter protein MyD88. The CD11b+ DC population within Flt3L DC had a higher level of maturation to Lm and uptake capacity than B220+ DC within Flt3L DC. While CD11b+ DC were capable of priming naïve T cells, B220+ DC were also capable of priming T cells when the level of …
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[Beta]-amyloid-mediated nitric oxide release from rat microglia by ligation of the integrin Mac-1
… each subunit of Mac-1 (anti-CD18 and anti-CD11b) and (2) competitive binding assay of fluorochrome-labeled [beta]25-35 with anti-CD18 or anti-CD11b by fluorescent flow cytometry. The results demonstrate that binding of CD18 and CD11b on microglial cells are individually sufficient to elicit …
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The Role of Insulin-Like Growth Factor-I in Myeloid Cell Differentiation
… cycle. Indeed, IGF-I increases expression of CD11b, CD14 and the $\alpha$-naphthyl acetate esterase of mature macrophage. Cell growth and cell cycle analysis revealed that IGF-I promoted cells advancing through the cell cycle as well as enhances macrophage differentiation. Western blot …
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The effects of calorie restriction and aging on natural killer cells in c57bl/6 mice
… reduced levels of terminally mature (CD27-CD11b+) NK cells and had increased expression of the immature marker CD127 and decreased expression of the mature marker DX5. We also compared NK cells from 22 mo old aged mice that were calorie restricted from either 4 months of age (young-onset …
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Characterization of Dendritic Cells in the Bovine Mammary Gland
… mammary DC as expressing CD11c, MHC-II, CD205, CD11b, and CD8α. FACS allowed us to distinguish DC (CD14lo) from macrophages (CD14hi). Two DC subsets, CD11a-, CD11alo, were evident in the mammary gland while an additional CD11ahi population was identified in the supramammary lymph node. After …
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Vulnerability to cognitive, neurotoxic and neuroinflammatory effects of toxins that induce Parkinson's disease after administration of amphetamine-related drugs in mice
… of astroglia and microglia by GFAP and CD11b immunohistochemistry in motor areas, as substantia nigra compacta (SNc) and striatum, limbic and cortical areas, as hippocampus and medial prefrontal cortex (mPFC), was assessed. Degeneration of dopaminergic neurons by tyrosine hydroxylase …
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Targeting of specific developmental pathways to understand dendritic cell heterogeneity and function
… of the key T cell-priming populations of CD11b DCs in the spleen and intestine. Specific targeting of Notch2 revealed that splenic CD11b DCs are comprised of at least two functionally and developmentally distinct populations that can be distinguished by their expression of the surface …
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HDAC6 Deletion Decreases Pristane-Induced Inflammation and Lupus
… pristane treatment promoted the population of CD11b+Ly6C++ inflammatory monocytes and CD11b+Ly6G+ neutrophils. Peritoneal recruitment of these inflammatory monocytes and neutrophils in HDAC6-/- mice was significantly decreased compared to the WT mice. Pristane treatment also induced the …
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Ehrlichiosis: Understanding immune mechanisms that lead to the development of fatal disease
… IOE had increased splenic and hepatic numbers of CD11b+ cells, increased hepatic CD4+ and CD8+ T cells, and decreased splenic CD4+ T cells. Because of the observed differences in NKT cells, I investigated the role of CD1d-restricted NKT cells in induction of toxic shock-like syndrome. Absence of …
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The Role of Complement in Ischemic Heart Disease in Type 2 Diabetes Mellitus
… we measured C3 deposition, PMN accumulation, PMN CD11b expression, and ICAM-1 expression. We found significantly more C3 deposition, PMN accumulation, ICAM-1 and PMN CD11b expression in diabetic samples compared to non-diabetic samples. To elucidate a role for complement system activation, we …
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Understanding the Role of Dendritic Cell Subsets in the Generation of a CD8+ T Cell Response Following Pulmonary Vaccinia Viral Infection
… present within the lung tissue (CD103+ DC and CD11b+ DC) and draining lymph nodes (MLN) (CD8α+), and as such, all are potential regulators of T cell activation (for review see1,2). These studies sought to understand how DC subsets contribute to the generation of virus-specific CD8+ T cells …
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Experimentelle Untersuchungen zur zellbiologischen Charakterisierung Inflammatorischer Dendritischer Epidermaler Zellen in entzündlich veränderter Epidermis
… Während sowohl IDEC als auch MoDC stark CD36, CD11b und CLA exprimieren, sind auf LC CD36 und CD11b nur minimal und CLA deutlich weniger stark exprimiert. Außerdem konnte gezeigt werden, daß die CD1a- Expression der MoDC mit längerer Kulturdauer stärker wird, und daß eine Zugabe von autologem …
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Differential expression of beta 2 integrins in Korean Behcet’s disease patients
… (HC) were included. The expression of CD11a, CD11b, CD11c, as well as CD4, CD8, CD18 and CD56 in peripheral blood mononuclear cells was assessed by flow cytometry. The transcriptional level expression of CD11a and CD11c was assessed by reverse transcription polymerase charin reaction.Western …
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TREM-2 and Dendritic Cells in the Pathogenesis of Allergic Airway Inflammation
… two major subsets based on the expression of CD11b and CD103. Both subsets have been shown to drive pro- or anti-inflammatory responses based on stimulus and cytokine environment.|Dendritic cells express several pattern recognition receptors (PRRs) that are critical for their function as …
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Intestinal macrophages in health and inflammation
… (PEC mφ) exhibited the conventional F4/80+CD11b+CD11c- phenotype of classical mφ and upregulated costimulatory molecules in response to TLR ligation. In stark contrast, the colon contained three F4/80+ subsets, one F4/80+CD11b+CD11cint, one F4/80+CD11b+CD11c- and a smaller population of …
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Study of anti-inflammatory functions of HDL in experimental mouse models
… of an increase in ‘mildly pro-inflammatory’ Cd11b+LyCmid monocytes, whereas ‘highly pro-inflammatory’ Cd11b+LyChi monocytes were reduced. In line with this observation, Kuppfer cells in the Lcat-/- liver had a rather anti-inflammatory, regulatory phenotype, while peritoneal macrophages of …
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Acute Pro-inflammatory Immune Response Following Different Resistance Exercise Protocols in Trained Men
… in plasma TNF?, MCP-1, and expression of CCR2, CD11b, and GCR on CD14++CD16- monocytes were similar following HVY and VOL. When collapsed across groups, TNF? was significantly increased at IP, 30P, 1H and 2H post-exercise (p = 0.001 – 0.004), while MCP-1 was significantly elevated at all …
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Cellular Immunity in Mouse Models of Viral Encephalitis
… primarily of myeloid cells (CD45<sup>high</sup>CD11b<sup> +</sup>), CD4<sup>+</sup> and CD8<sup>+</sup> T cells; the latter subset containing cells specific for the immunodominant VSV nuclear protein epitope. Although the CD45<sup>high</sup>CD11b+ phenotype suggests that these cells are …
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