Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"ccRCC"”.
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HIF2a regulates ccRCC tumorigenesis through activation of cell cycle regulators
Clear cell renal cell carcinoma (ccRCC) is the most frequent type of kidney cancer, with 50% 5-year survival. Genetically, ccRCCs are characterised by inactivation of VHL which is lost in 90% of cases. Inactivating mutations of VHL lead to stabilisation of HIF2α which in turn drives the expression …
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Characterisation of HIF2A targets identifies MYC as a key determinant of HIF2A dependency in ccRCC
Despite advancements in ccRCC treatment, the prognosis for metastatic disease remains poor with a 5-year survival of approximately 10%. VHL loss is an early driver event in the vast majority of ccRCC cases and results in constitutive activation of HIF2A, making HIF2A an important clinical target. …
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A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is characterised by frequent inactivation of the VHL tumour suppressor gene and consequent accumulation of HIF2A that drives tumourigenesis. The current clinically-approved therapies for ccRCC are those targeting the angiogenesis and mTOR signalling pathways, …
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Ageing and regeneration-associated transcriptional state transitions and tumour-stroma interaction in early renal carcinogenesis
… among which clear cell renal cell carcinoma (ccRCC) is the most common subtype. VHL inactivation is the most common mutation seen in ccRCC with more than 90% of tumours had clonal disruption of the VHL pathway. Although it is the initial oncogenic insult in ccRCC, it takes decades after VHL …
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Investigating the role of SWI/SNF chromatin remodelling complex in Clear Cell Renal Cell Carcinoma
… 40% of clear cell type renal cell carcinoma (ccRCC). In this study, we characterised the composition of SWI/SNF complexes in ccRCC cells finding that the PBRM1 and SMARCC1 subunits are frequently depleted in ccRCC cell lines. Furthermore, using a ccRCC specific tissue microarray, these …
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Autologous Proliferative and Immunobiological Modelling of Patient-Derived Clear Cell Renal Cell Carcinoma and Kidney Organoids
… for advanced clear cell Renal Cell Carcinoma (ccRCC), the deadliest urological malignancy. However, both efficacy and toxicity of immunotherapies is highly patient-specific and difficult to predict. This underscores the need for robust preclinical models of ccRCC-immunotherapy. Current models …
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Axl RTK and microRNAs in urogenital cancers
… microRNAs in clear cell renal cell carcinoma (ccRCC) and in prostate cancer (PCa). Paper I focuses on differentially expressed microRNAs in ccRCC. We used bioinformatics methods to identify candidate microRNAs in a publically available cohort of ccRCC, which were measured in a cohort of 198 RCC …
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Identification and characterisation of HNF1B as a pro-tumorigenic lineage factor in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer. ccRCCs exhibit considerable genetic intratumour heterogeneity, and current therapies lack long-term efficacy due to drug resistance. Novel therapeutic targets are thus required to combat this disease. The most …
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Diagnostic and prognostic DNA methylation biomarkers of renal clear cell carcinoma /
Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney tumor with the highest incidence rates in Lithuania. CcRCC is characterized by the highest mortality rate of genitourinary cancers, therefore, new diagnostic and/or prognostic biomarkers are urgently needed. Considering this, …
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Notch Signaling in Neuroblastoma and Renal Cell Carcinoma
… cell line. Clear cell renal cell carcinoma (CCRCC) is characterized by activation of the hypoxia inducible factor (HIF) pathway due to functional loss of the von Hippel-Lindau tumor suppressor gene. However, cooperating oncogenic events parallel to the HIF pathway remains poorly described. …
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Role of Hypoxia-inducible Factor in Kidney Cancer
… development of clear-cell renal cell carcinoma (ccRCC), the most common form of kidney cancer. In particular, overexpression of HIF2alpha has been intimately linked to ccRCC molecular pathogenesis. Here, we report that HIF2alpha overexpression leads to Akt-mediated hyperactivation of Hdm2, …
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Characterising DNA methylation in tissue and liquid samples from patients with renal tumours
… the most common of which is clear cell RCC (ccRCC). Current methods are unable to confidently distinguish pathological subtypes of SRMs, meaning patients with benign tumours are undergoing unnecessary invasive surgery. In addition, there are difficulties risk stratifying patients with ccRCC …
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Prolyl Isomerase Pin1 Is a Conditional Tumor Suppressor
… role in human clear cell renal cell carcinoma (ccRCC). Here we show evidence for PIN1 gene deletion and mRNA under-expression as a mechanism of Pin1 reduction in ccRCC tumors. We demonstrate that restoration of Pin1 in cell lines found to be deficient in Pin1 protein expression can attenuate the …
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Prognostic Significance of Chromosome 9p Deletion in Clear Cell Renal Cell Carcinoma
… prognostic factor in clear cell subtype (ccRCC). The findings from these studies initially appeared promising however they were of limited clinical applicability due to lack of standardisation of molecular techniques employed and short periods of follow-up. In addition these studies did …
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Modulating Immunometabolism to Improve The Activity of Car-Nk Cells Targeting Cd70 In Renal Cell Carcinoma
… for metastatic clear cell renal cell carcinoma (ccRCC), disease resistance and relapse are common, and therapies with novel mechanisms of action are urgently needed. Chimeric antigen receptor (CAR) T-cell therapy has shown remarkable responses in hematologic malignancies, but many obstacles …
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Studies on renal progenitor cells and kidney cancer
… correlate to worse prognosis in clear cell RCC (ccRCC). These results indicate that these cells survive renal insults to a higher extent than bulk proximal tubule cells, and become activated to repopulate the tubule, but also suggest that pRCC might originate from oncogenic transformation of …
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Endogenous Reporter Systems for High-Throughput Functional Screening in Clear Cell Renal Cell Carcinoma
… approaches. In clear cell renal cell carcinoma (ccRCC), loss of von Hippel-Lindau tumour suppressor (VHL), seen in 90% of ccRCCs, leads to the stabilization of hypoxia inducible factor HIF2A and aberrant expression of its downstream targets such as the chemokine receptor CXCR4. Activation of …
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Mechanisms of Synthetic Lethality in Renal Cell Carcinoma
Clear cell renal cell carcinoma (ccRCC), the most common subtype of kidney cancer, is characterised by biallelic inactivation of the von Hippel-Lindau (*VHL*) tumour suppressor gene, and inherited loss-of-heterozygosity of *VHL* underlies the eponymous hereditary cancer syndrome. The *VHL* protein …
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DEVELOPMENT OF BISPECIFIC T CELL ENGAGERS TARGETING CARBONIC ANHYDRASE 9 FOR THE IMMUNE THERAPY OF CLEAR CELL RENAL CELL CARCINOMA
Advanced clear cell renal cell carcinoma (ccRCC) is responsible for nearly 70% of kidney cancers and 10,000 yearly deaths in the Unites States. While immunotherapies have demonstrated potential, poor chances of long-term survival remain for advanced cases. Yet to reach patients are bispecific T …
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Caractérisation du STF-62247 comme un inhibiteur de PIKfyve dans les carcinomes rénaux à cellules claires
… 2) surexprimer PIKfyve dans un modèle cellulaire ccRCC et 3) d'identifier les résidus de PIKfyve qui subissent une phosphorylation en réponse à un traitement au STF-62247. Nos résultats démontrent un décalage supérieur de la bande de PIKfyve dans les cellules ccRCC traitées au STF-62247 lors …
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