Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"cbb3"”.
-
Simulation studies of the structure-function relationship of two biological processes: proton pumping in cbb3 oxidase and activation of Parkin
… enzymes: a C-type cytochrome c oxidase (cbb3) and an E3 ubiquitin ligase (Parkin).<br/><br/>Cbb3 is a C-type terminal oxidase responsible for catalyzing the final step of aerobic respiration (namely the reduction of oxygen to water) and coupling this redox reaction to the active …
-
Studies of cytochrome c oxidases from Rhodobacter sphaeroides and Vibrio cholerae
… second largest group, C-type, is also known as cbb3 cytochrome c oxidase which is almost exclusively found in the Proteobacteria. All the current studies show that cytochrome cbb3 oxidases apply quite distinct mechanism for receiving electrons and pumping protons. The work in this thesis clearly …
-
Studies of proton pumping mechanism in BA3 type cytochrome oxidase of thermus thermophilus and CBB3 type cytochrome oxidase of vibrio cholerae
… cytochrome c4 is a substrate for the purified cbb3 oxygen reductase and can support steady state oxygen reductase activity of at least 300 e-1/s. In contrast, reduced cytochrome c5 is not a substrate for the cbb3 oxygen reductase. Cyclic voltammetry was used to determine that the midpoint …
-
Electron cryomicroscopy structures of respiratory supercomplexes from alphaproteobacteria suggest mechanisms to enhance catalysis and to prevent deactivation of respiratory complex I
… supercomplexes – CI2CIII2CIV2, CI1CIII2CIV2(cbb3)1, CI1CIII2CIV2, CI1CIII2CIV1 and CIII2CIV2 were resolved at resolutions of ~3 - 7 Å. The structures demonstrate that bacterial supercomplexes are modular and assembled from minimal components essential for its catalytic function. Intriguingly, …
-
The electron transport chains of Neisseria meningitidis
… c4 and c2 are major electron donors to the cbb3 oxidase. Both strains deficient in cytochrome c4 and c2 exhibits a growth defect under high level of oxygen. These growth defects are linked to their decreased oxygen consumption rate. The growth defect and the decreased oxygen consumption rate …
-
Studies on the structure, function and mechanisms of the cbb3 type cytochrome c oxidase from Vibrio cholerae and the cytochrome bo3 ubiquinol oxidase from Escherichia coli
… cycle for dioxygen reduction. In this study, cbb3 type cytochrome c oxidase from V. cholerae and bo3 type ubiquinol oxidase from E. coli were investigated separately. Site directed mutagenesis were carried out in the case of cbb3 protein based on crystal structure and sequence alignment. …
-
Studies of Cytochrome C Oxidases From Rhodobacter Sphaeroides and Vibrio Cholerae
… second largest group, C-type, is also known as cbb3 cytochrome c oxidase which is almost exclusively found in the Proteobacteria. All the current studies show that cytochrome cbb3 oxidases apply quite distinct mechanism for receiving electrons and pumping protons. The work in this thesis clearly …
-
Engineering heme-copper and multi-copper oxidases for efficient oxygen reduction catalysis
… comparable to that of a native cytochrome (cyt) cbb3 oxidase (50 s−1) under identical conditions. We achieved this goal by engineering more favorable electrostatic interactions between a functional oxidase model designed in sperm whale myoglobin and its native redox partner, cyt b5, resulting in …
-
Biochemical characterization of C-family heme copper oxygen reductase
Heme copper oxygen reductases (HCOs) are key enzymes for aerobic respiration. As a terminal electron acceptor, HCO catalyzes the sequential transfer of four electrons from reduced cytochromes c on the P-side of the membrane, and four protons from the cytosol on the N-side, to molecular O2 bound at …