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Showing 1 to 6 of 6 for “"caveolin-3"”.
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Funktionelle und strukturelle Analysen von Mutationen im Caveolin-3-Gen
The protein caveolin-3 is the most important scaffolding-protein of the caveolar membrane domains in the smooth-, the skeletal- and the heart muscles. Mutations in the caveolin-3 gene are proposed to be responsible for a variety of hereditary myopathies which range from mild forms such as …
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Modulation of Mitochondrial Respiration and Metabolic Signalling in Skeletal Muscle by Caveolin-3
Caveolins (Cavs) represent the principal constituent of caveolae, and since their discovery have long been associated with the plasma membrane as regulators of cholesterol homeostasis and scaffolds for signalling molecules and receptors such as the insulin receptor. Recent work however, has …
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Spatial organization of sodium calcium exchanger and caveolin-3 in developing mammalian ventricular cardiomyocytes
… we investigated the spatial arrangement of caveolin-3 (cav-3), the principle structural protein of small membrane invaginations named caveolae, and NCX in developing rabbit ventricular myocytes. Using traditional as well as novel image processing and analysis techniques, both qualitative and …
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Palmitoylation and Glutathionylation of Key Sarcolemmal Signalling Proteins in Cardiac Muscle
… and G alpha i (Gai) and the scaffolding protein, Caveolin 3 (Cav3). Cav3 acts as a negative regulator binding many proteins eg. Ga proteins, in the caveolae to maintain efficient signalling within the cardiomyocyte. Interaction and co localisation of Cav3 and G protein a subunits is disrupted …
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Characterization of the sarcolemma in limb-girdle muscular dystrophy
… functions. LGMD 1C is caused by mutations in the caveolin-3 (cav-3) gene. Cav-3 is the muscle-specific isoform of the caveolin protein family which represent, together with the cavin protein family, the major structural and functional components of caveolae. Caveolae are plasma membrane …