Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"caveolin"”.
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Expression und Funktion von Caveolin bei glialen Zellen, insbesondere Oligodendrozyten
Caveolin-haltige Mikrodomänen (CMD) sind sphingomyelin-, glykosphingolipid- und cholesterinreiche Membranabschnitte innerhalb der Plasmamembran. Zu ihren physiologischen Aufgaben gehören u.a. der vesikuläre Transport und die Signaltransduktion. Caveolae sind als Sonderform von CMD anzusehen. Anhand …
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EHBP1 and EHD2 Regulate Dll4 Caveolin-Mediated Endocytosis During Blood Vessel Development
<p>During angiogenesis, the development of new blood vessels from existing vessels, there must be tight regulation between a leading tip cell and trailing stalk cells during vascular patterning. Lateral inhibition produced by Notch signaling is central to the specification and maintenance of tip …
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Modulation of Mitochondrial Respiration and Metabolic Signalling in Skeletal Muscle by Caveolin-3
Caveolins (Cavs) represent the principal constituent of caveolae, and since their discovery have long been associated with the plasma membrane as regulators of cholesterol homeostasis and scaffolds for signalling molecules and receptors such as the insulin receptor. Recent work however, has …
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Spatial organization of sodium calcium exchanger and caveolin-3 in developing mammalian ventricular cardiomyocytes
… we investigated the spatial arrangement of caveolin-3 (cav-3), the principle structural protein of small membrane invaginations named caveolae, and NCX in developing rabbit ventricular myocytes. Using traditional as well as novel image processing and analysis techniques, both qualitative and …
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Correlation of Caveolin-1 Expression on Tissue Microarray with Prognosis in Renal Cell Carcinoma
… well to results obtained by standard methods. Caveolin-1 is a major structural component of caveolae, which are plasma membrane microdomains implicated in the regulation of intracellular signaling pathways. Altered caveolin-1 expression is thought to be involved in several important human …
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Impact of Caveolin-1 Expression and Microvessel Density on the Prognosis of Upper Urinary Tract Transitional Cell Carcinoma
PURPOSE: Caveolin-1 is a principal component of caveolae membranes and plays a regulatory role in several signal pathways. It may also be crucial in the organization of caveolae of endothelial cells and in regulating endothelial cell differentiation and angiogenesis. Caveolin-1 has been reported to …
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Regulation of receptor signaling and membrane trafficking by beta1,6-branched n-glycans and caveolin-1/cholesterol membrane domain organization
… opposes receptor sequestration by oligomerized caveolin-1 (Cav1) domains overriding its negative regulation of epidermal growth factor receptor (EGFR) signaling, cell surface diffusion and tumor growth. These results identify Cav1 as a conditional tumor suppressor. I also demonstrate that Cav1 …
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Effect of uptake pathway on non-viral gene delivery in vitro and in vivo
… Previously, the Pack lab has demonstrated that caveolin-mediated endocytosis is important to in vitro polyethylenimine (PEI)- and polyamidoamine (PAMAM)-mediated gene delivery in HeLa cells through the use of small molecule drugs and small-interfering RNA [1-2]. The goal of this thesis is to …
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Functional in vitro analyses of lipid raft-associated cathepsin b: implication for the invasive phenotype of inflammatory breast cancer
… co-</p> <p>expression of cathepsin B and caveolin-1 was found in IBC patient </p> <p>biopsies, thus validating our in vitro data. To determine whether the </p> <p>uPA and cathepsin B present at the cell surface is localized </p> <p>specifically to caveolae and investigate if caveolae are a …
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A Study of the Sequestration of Melanin-Concentrating Hormone Receptor-1 in Caveolae: A Potential Mode of Cell Signaling Regulation by an Appetite-Stimulating Hormone
… centrifugation MCHR1 co-localizes with caveolin-1, suggesting a role for lipid rafts in receptor dynamics. This thesis will examine the extent of interaction between caveolin-1 and MCHR1. The first aim will be to determine the degree of co-localization of receptor and caveolin-1 under …
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Melanin-Concentrating Hormone Receptor-1 is Enriched in Lipid Rafts and the Effects of Lipid Raft Integrity on Receptor Signaling
… to note, fat cells accumulate caveolae markers -caveolin-1 and cholesterol -during this process. Certain GPCRs and their associated downstream signaling molecules co-localize with caveolae membranes. This thesis seeks to demonstrate that MCHR-1 is enriched in lipid rafts and that a possible …
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Identification of the receptor for cellular internalization of an anti-nucleic acid antibody, 3D8 scFv
… molecules were observed between 3D8 scFv-HSPGs-caveolin 1, and 3D8 scFv-CSPGs-caveolin 1 in HeLa cells. Furthermore, internalization of 3D8 scFv was significantly reduced in HS/CS-deficient CHO cells (pgsA-745), compared to in wild-type CHO cells. These data provide the evidence for both HSPGs …
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Caveolins and NJKs Influence Brain Endothelial Permeability after Juvenile TBI
… the juvenile brain. To this end, the endothelial caveolins and c-Jun N-terminal kinases (JNKs) were identified as proteins of interest in the regulation of brain endothelial permeability after injury. These were investigated under a three-fold aim. The first was to characterize the acute and …
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CAVEOLAE AS SPATIO-TEMPORAL COMPARTMENTS FOR ROS/RNS GENERATION AND NITROXIDATIVE STRESS SIGNALING
… in this process, cultured cells were depleted of caveolin-1 (siRNA). Similar to inhibitors, TNFα failed to induce protein-tyrosine nitration, activate NFkB or enhance adhesion molecule expression in cells lacking caveolin-1. These findings were corroborated in vivo using Cav1KO animals. Our …
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Hormonal regulation of phosphodiesterase 3B in adipocytes
… rat and mouse adipocytes, 3T3-L1 adipocytes and caveolin-1 knock out mouse adipocytes. The study on PDE3B phosphorylation shows that PDE3B is multisite phosphorylated in response to both insulin and catecholamines. We were able to identify six phosphorylation sites on PDE3B namely; 273, S296, …
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The Regulation of Cholesterol Absorption: Nuclear Hormone Receptors and Niemann-Pick C1 Like 1
… of the cholesterol transport machinery, caveolin-1 (CAV1), is neither required for intestinal cholesterol transport or sensitivity to the novel cholesterol absorption blocking agent, ezetimibe. This rules out a critical role for caveolin-1 and lends further support to the contention that …
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Integration of signalling in smooth muscle caveolae
… to play a role in cellular signalling. Caveolins and cavins as well as cholesterol are required for the structure and function of caveolae. The papers summarized in this thesis examine the role of caveolae in smooth muscle function. Ca2+-sensitization is a contractile process depending …
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Structural and Functional Characterization of GAPR-1, a Mammalian Plant Pathogenesis-related Protein in Lipid-enriched Microdomains of the Golgi Complex
… sequence for myristoylation, a putative caveolin-binding domain, a coiled-coil structure, and an isolelectric point (pI) of 9.4, suggesting that GAPR-1 is a highly hydrophilic protein (Eberle, H. B. et al. 2002). In this thesis, this structural information, was used to i) study the …
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Lipid Rafts in Pancreatic Beta- and Alpha-cell Stimulus-secretion Coupling
… expression of lipid raft constituent proteins, caveolin-1/2 in pancreatic beta-cells; and caveolin-2 in alpha-cells. A variety of membrane proteins (ion channels and SNARE proteins) critical for beta- and alpha-cell stimulus-secretion coupling were found to be associated with cholesterol-rich …
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