Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"caveolae"”.
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The role of EHD proteins in caveolae, and the role of caveolae in adipocytes
Caveolae are 50-60 nm flask-shaped invaginations of the plasma membrane that protect the plasma membrane from damage under stretch forces. They are highly abundant in cells that experience high levels of stress forces such as adipocytes, endothelial cells and muscle cells. Caveolae are generated by …
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Integration of signalling in smooth muscle caveolae
Caveolae and lipid rafts are plasma membrane microdomains that are considered to play a role in cellular signalling. Caveolins and cavins as well as cholesterol are required for the structure and function of caveolae. The papers summarized in this thesis examine the role of caveolae in smooth …
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Investigation of caveolae-mediated endocytosis in response to interferon
Cancer contributes substantially to overall mortality and morbidity worldwide, resulting in considerable research focused on treatments. Yet many types of cancers continue to have a poor prognosis [1]. Cancer is an incredibly diverse affliction, resulting from numerous changes in normal cell …
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THE ROLE OF CAVEOLAE IN THE FORMATION OF ABDOMINAL AORTIC ANEURYSMS
… factors such as matrix metalloproteases (MMP's). Caveolae has been shown to play a role in a number of different cardiovascular diseases through different mechanisms including regulation of oxidative stress, inflammation and degradation of extracellular matrix components through MMP's. In …
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CAVEOLAE AS SPATIO-TEMPORAL COMPARTMENTS FOR ROS/RNS GENERATION AND NITROXIDATIVE STRESS SIGNALING
… complexes and eNOS localize to endothelial caveolae microdomains. Additionally, caveolae internalization has been shown as an activating mechanism for enzyme eNOS. However, roles of caveolae in ROS/RNS generation and downstream signaling roles in activating endothelial cells are not well …
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K+-Induced Smooth Muscle Calcium Sensitization Requires RhoA Kinase (ROK) Translocation to Caveolae Which Is Inhibited in Non-Neuronal Cell Memory
… nearly doubled the amount o f ROK colocalized to caveolae at 30”, a time that preceded inhibition of force by Y-27632. Colocalization was not inhibited by Y-27632, but was abolished by nifedipine and the calmodulin blocker, trifluoperazine. Since, -30% of RhoA is colocalized with caveolin basally, …
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Melanin-Concentrating Hormone Receptor-1 is Enriched in Lipid Rafts and the Effects of Lipid Raft Integrity on Receptor Signaling
… Of interest to note, fat cells accumulate caveolae markers -caveolin-1 and cholesterol -during this process. Certain GPCRs and their associated downstream signaling molecules co-localize with caveolae membranes. This thesis seeks to demonstrate that MCHR-1 is enriched in lipid rafts and …
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Die Plasmamembran-Kalzium-ATPase im Myokard
… aufzudecken. Dabei wurden im Speziellen die Caveolae als Ort der möglichen Lokalisation untersucht, kleine, ca. 50-100 nm große Einstülpungen der Plasmamembran, mit charakteristischer Lipid- und Proteinzusammensetzung, darunter auch viele Rezeptoren und Signaltransduktionsmoleküle. Insgesamt …
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Zelluläre Aufnahme und intrazelluläres Schicksal von partikulären Drug Delivery Systemen
… in die Zelle, wie Phagocytose, Makropinocytose, Caveolae-vermittelte Endozytose und so genannte Non-Clathrin-non-Caveolae vermittelte Endozytose. Von diesen Wegen erscheint die Internalisierung mittels Caveolae besonders viel versprechend für ein gezieltes Drug Targeting zu sein, da hier das …
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A Study of the Sequestration of Melanin-Concentrating Hormone Receptor-1 in Caveolae: A Potential Mode of Cell Signaling Regulation by an Appetite-Stimulating Hormone
… be to analyze the dynamics of the MCHR1 within caveolae after MCH stimulation and with expression of the arrestins. The goal will be to better understand the interaction between caveolae and MCHR1 and possibly provide insight into MCHR1 's mode of desensitization.
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Palmitoylation and Glutathionylation of Key Sarcolemmal Signalling Proteins in Cardiac Muscle
… binding many proteins eg. Ga proteins, in the caveolae to maintain efficient signalling within the cardiomyocyte. Interaction and co localisation of Cav3 and G protein a subunits is disrupted following an diamide induced increase in glutathionylation. However, sucrose gradient fractionation …
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Functional in vitro analyses of lipid raft-associated cathepsin b: implication for the invasive phenotype of inflammatory breast cancer
… active </p> <p>cathepsin B were all present in caveolae fractions isolated from </p> <p>SUM149 cells. Using a live-cell proteolysis assay, we demonstrated </p> <p>that both IBC cell lines degrade type IV collagen. The SUM149 cells </p> <p>exhibit predominantly pericellular proteolysis, …
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Biological studies of organellar (Na⁺,K⁺)/H⁺ exchanger NHE7
… internalized. Caveolins, structural proteins for caveolae, were identified as NHE7-binding proteins and it was initially hypothesized that caveolins might regulate NHE7-internalization. Interestingly, caveolins bound to NHE7 through a novel binding domain and facilitated its association to …
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Hormonal regulation of phosphodiesterase 3B in adipocytes
… we conclude that PDE3B is localized to caveolae and endoplasmic reticulum (ER) in adipocytes and that caveolae localized PDE3B is specifically activated by catecholamines while PDE3B in ER is specifically activated by insulin. Finally, the studies on PDE3B interactions demonstrate that …
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Beteiligung der Plasmamembran Ca2+-ATPase an Wachstumsregulation und Signaltransduktion im Überexpressionsmodell und im Myokard transgener Ratten
… wird dies durch die Lokalisation der ATPase in Caveolae, spezifischen Membraninvaginationen, in denen wichtige Zentren der zellulären Signalverarbeitung gesehen werden. Ziel: Mit der vorliegenden Arbeit sollte die Funktion der Plasmamembran Ca2+-ATPase, insbesondere eine mögliche Beteiligung des …
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The Effect of Endocytosis of Interferon-lambda and The Genotype of IL-10RB on The Cellular Responses to Cytokines
… Endocytosis는 크게 clathrin-dependent/-independent, caveolae-dependent /-independent pathway와 그 외의 다른 pathway들로 분류 된다. 또한 dynamin II 관련에 의해 endocytosis 경로가 세분화된다. Interferon (IFN)은 type I, type II, 그리고 type III의 세 그룹으로 분류되며, Interferon lambda는 IFN-1, IFN-2, IFN-3로 다시 나누어지고 최근에 type III로 분류되면서 새로운 …
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Untersuchung der funktionellen Interaktion zwischen der sarkolemmalen Calcium-ATPase und der neuronalen NO-Synthase
… werden. PMCA und nNO-Synthase kommen in Caveolae von Kardiomyocyten vor. Humane PMCA4b überexprimierende Rattenherzen zeigen ex vivo eine signifikant höhere cGMP-Konzentration als wildtypische Rattenherzen. Das Ergebnis kann in mit PMCA4b und nNOS transfizierten wildtypischen und …
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Cellular determinants of reovirus entry and infection
… Reovirus can also infect cells that lack caveolae. To assess whether reovirus used different endocytic pathways to infect cells devoid of caveolae, we analyzed reovirus entry and infection in polarized Caco-2 cells. While reovirus infection of these cells was dynamin-independent, particle …
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Spatial organization of sodium calcium exchanger and caveolin-3 in developing mammalian ventricular cardiomyocytes
… protein of small membrane invaginations named caveolae, and NCX in developing rabbit ventricular myocytes. Using traditional as well as novel image processing and analysis techniques, both qualitative and quantitative findings firmly establish the highly robust and organized nature of NCX and …
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Regulation of receptor signaling and membrane trafficking by beta1,6-branched n-glycans and caveolin-1/cholesterol membrane domain organization
… subunit to the Golgi apparatus independently of caveolae formation. That identifies a new role for caveolin-1 outside caveolae in the regulation of raft-dependent endocytosis Finally, Mgat5 overexpression in pneumocytes is associated with the expression of a lysosomal organelle, the multilamellar …
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