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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"cationic peptides"”.
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ANTIMICROBIAL ACTIVITIES OF HISTIDINE-RICH GLYCOPROTEIN AND CATIONIC PEPTIDES
… a fast and effective defence. Antimicrobial peptides are ancient and integral effector molecules of the innate immune system. They are found in all kinds of species from bacteria to plants and animals, indicating their importance during evolution. They possess a broad-spectrum antimicrobial …
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Conjugation of Zwitterionic and Cationic Peptides to Lipid and Polymer for Gene Delivery
… by the chemical conjugation between the peptides and the corresponding backbones. In total, we focus on 3 types of conjugates mainly. They are the zwitterionic peptide (EK)x pair lipid DSPE conjugates, THE DSPE-(EK)x, the cationic ionizable peptide RxHy lipid DSPE conjugates, the …
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A Study of The Effect of Membrane Targeting Antimicrobial Compounds on Ionic Transport Across Lipid Bilayer Membranes
The novel synthetic cationic peptide melimine is a chimera of two natural peptides, melittin and protamine. This peptide has a broad spectrum of antibacterial activity against both gram-positive and gram-negative bacteria while having no toxicity in mammalian cells. Melimine was initially …
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Structural transitions in self-assembled lipid systems driven by induced curvature: from cell-penetrating peptides to programmable vesicles
Arginine rich cell-penetrating peptides are short cationic peptides capable of traversing the plasma membranes of eukaryotic cells. While successful intracellular delivery of many biologically active macromolecules has been accomplished using these peptides, their mechanisms of cell entry are still …
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Requirement of ßDELSEED-Motif of <em>Escherichia coli</em> F<sub>1</sub>F<sub>O</sub> ATP Synthase in Antimicrobial Peptide Binding.
… and hydrolyzing ATP. Lately, α-helical cationic peptides such as melittin and melittin related peptide (MRP) were shown to inhibit <em>E. coli</em> ATP synthase. The proposed but unconfirmed site of inhibition is βDELSEED-motif formed by the residues 380-386, located at the interface of …
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Engineering membrane-selective antibiotic peptides to combat multidrug resistance
… development strategies. Natural antimicrobial peptides (AMPs) have been long-recognized as a potential source of bacteriolytic drugs, but the shortcomings of non-specific membrane toxicity, proteolytic instability, and in vivo toxicity have stymied their clinical translation. Here, we subjected …
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Identification and activity assessment of a bioactive peptide QUB-2642 from the skin secretion of The American Bullfrog (Rana catesbeiana)
… in microbial pathogens has made antimicrobial peptides a very attractive option for new-generation antibiotics. Amongst antimicrobial peptides widespread in different classes of life, those derived from amphibians have been receiving special research attention since the last century. Secreted …
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PEPTIDE ENGINEERING FOR DEVELOPMENT OF ANTIMICROBIALS AGAINST Mannheimia haemolytica
… have shown poor vaccine efficacy. Antimicrobial peptides (AMPs) may help in the management of respiratory disease caused by M. haemolytica while minimizing the risk of drug residues in animal-derived food products. AMPs are positively charged molecules that can kill bacteria primarily through the …
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MUTACIN IV PRODUCTION IN STREPTOCOCCUS MUTANS UA159: CHARACTERIZATION, REGULATION, AND MECHANISM OF SELF-IMMUNITY
… is facilitated by ribosomally synthesized small cationic peptides called mutacins (bacteriocins) secreted by S. mutans. Although for long time mutacins are regarded as important virulence factors, it is not clear how these peptides work, what is the mechanism of self-immunity, and how they are …