Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"cathepsin S"”.
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Cathepsin S as a mediator of acute lung inflammation
… warrant investigation. The cysteine protease, cathepsin S (CTSS), is emerging as an influential mediator of pulmonary disease and may represent a novel target for the treatment of chronic and acute inflammatory lung conditions. <br/>In this thesis, we first evaluated the status of CTSS in the …
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Cracking the code of cathepsin S: Structural determinants of specificity switching
Cathepsin S is a cysteine protease in the papain family that digests antigens as part of the adaptive immune response, activates receptors, and is associated with extracellular matrix degradation in autoimmune diseases and cancer. A comprehensive review of the literature revealed potential pH- and …
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The synthesis, characterization, and use of a protein-cysteine proteinase inhibitor complex for the study of endosome/lysosome fusion
The cysteine proteinases cathepsins B, L, and S are lysosomal enzymes responsible for the degradation of endocytosed proteins. Their presence in human cell monocytic lines THP1 and U937 was detected by the use of the membrane-permeable, irreversible, active-site directed inhibitor Fmoc-(¹²⁵I)Tyr- …
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Improving outcomes for obese children with Acute Lymphoblastic Leukaemia (ALL): a clinical collaboration to understand the influence of obesity on treatment success.
… weight gain. Also, resistin, serpin A12, IGFBP4, cathepsin-S and Angiopoetin-2 in MRD risk. We have shown that leptin, IL-8, serpin A12 and angiopoietin-2 have a protective effect when incubated with the Molt4 ALL cell line and that resistin does not offer this protection.Further experiments with …