Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"cathepsin K"”.
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Role of the ARF Tumor Suppressor in Osteoclasts
… mouse, in which Cre is controlled by the Cathepsin K promoter: Ctsk<super>Cre/+</super>). Surprisingly, we generated Arf -/- mice as demonstrated by genotyping, loss of ARF expression in the testis, and a phenotype comparable to traditional Arf -/- mice. Furthermore, both Cathepsin K and …
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Smoking and High-Fat Diet: Risk Factors Regulating Emphysema Formation
… we demonstrated that smoke-induced expression of Cathepsin K in the lungs contributes to the degradation of the extracellular matrix, ultimately resulting in emphysema. Studies in chapters three and four show that hypercholesterolemia is an important risk factor for pulmonary emphysema. These …
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Osteocyte Activity and Skeletal Muscle Relative Gene Expression Profiling After Short-term Muscle Paralysis
… apoptosis (caspase-3), perilacunar remodelling (cathepsin K), and staining of vascular pores and mast cells were assessed using immunohistochemistry. Real-time polymerase chain reaction (qPCR) was performed on the quadriceps muscles to assess relative expression differences for several …
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Methodologies For Attaching Polypyridyl Ligands Into Amino Acids And Synthesis And Biological Evaluation Of Novel Light Activated Peptidomimetic Cysteine Protease Inhibitors Caged By Ruii(bpy)2
… The syntheses of RuII(bpy)2 complexes caging cathepsin inhibitors are revealed with full characterization in the following chapters. The stability of the complexes in the dark in aqueous solutions and their ability to release the inhibitors upon irradiation with visible light are shown, …