Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"cathepsin D"”.
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Resveratrol Regulates IGF- II and Cathepsin D in Breast Cancer Cells
… cell modulation - i.e. apoptotie genes and Cathepsin D (CD), an estrogen-regulated protein elevated in breast cancer.</p> <p>RSV displays a biphasic effect on cell growth and IGF-II expression in ER+ breast carcinoma cells. In ER+ cells (MCF-7, T47D), RSV at 10<sup>-6</sup>M induces a 2-fold …
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Compound discovery and expression of a putative cathepsin D-like protease in Trichomonas vaginalis
… hydrolase. Another potential target is a cathepsin D-like protease found in T. vaginalis . This aspartic protease in humans is responsible for degrading proteins in the lysosome, and degrading hemoglobin in P. falciparum as the homologue plasmepsin. Searching the gene database, only one …
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Invitro protein synthesis and degradation and cathepsin D activity in the muscles of selenium-vitamin E deficient sheep
… synthesis and degradation capabilities and the cathepsin D activity of the skeletal muscles of experimentally induced Selenium-Vitamin E deficient lambs were investigated. Twenty-one Dorset x Coopworth x Suffolk lambs were blocked by weight and assigned to one of the following treatments: 1) a …
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The effect of calcium activated protease (CAF) and cathepsin D on bovine muscle myofibrils under varying conditions of pH and temperature
… study examined effects of purified CAF and cathepsin D on bovine skeletal myofibrillar proteins and structure when incubated under postmortem-like conditions of pH and temperature;When CAF (purified from bovine cardiac muscle) was incubated with isolated myofibrils under near optimal …
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Cyclooxygenase-2 and prostaglandins in human endometrial function
… 81 genes were differentially regulated including cathepsin D. Cathepsin D mRNA and protein expression were elevated in the cyclooxygenase-2 antisense cells compared with the sense and wild type cells. Cathepsin D is known to proteolytically cleave plasminogen to the antiangiogenic factor …
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Mechanistic study on the therapeutic strategy to enhance glioma cell death through inhibition of proteasome and lysosome
… treatment increased the active mature forms of cathepsin D, CQ treatment markedly blocked the processing and activity of cathepsin D. Interestingly, combined treatment induced the release of unprocessed cathepsin D into the cytosol and the recovery of its activity. Knockdown of cathepsin D …
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Effects of mitochondrial dysfunction on neurofilament turnover and distribution in human neuroblastoma cells
… chains are degraded by macroautophagy and cathepsin D, possibly with some involvement of cysteine cathepsin, but not calpain or the ubiquitin proteasome system (UPS). This is in contrast to α-synuclein which was degraded by macroautophagy, the UPS and calpain. Treatment with MPP+ did not …
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In vitro and in vivo imaging of peptide-encapsulated polymer nanoparticles for cancer biomarker activated drug delivery
… In this study, nanoparticles coated with cathepsin D-specific peptides were developed as a vehicle for the targeted delivery of the cancer drug doxorubicin (DOX) to treat breast malignancy. Cathepsin D, a breast cancer cell secretion, triggers the release of DOX by digesting the protective …
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Primary proteolysis of caseins in cheddar cheese
… bovine αs1-casein were determined. The action of cathepsin D, the principal indigenous acid milk proteinase, on caseins was studied and its pH optimum and sensitivity to NaCI determined. The action of cathepsin D on αs1-, αs2-, β- and κ-caseins was compared with that of chymosin and was found to …
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Characterisation of Vti1b and Vti1a proteins and generation of knock-out mice.
… und Asialofetuin, und reduzierte Reifung von Cathepsin D. Die elektronenmikroskopischen Daten haben gezeigt dass multivesikuläre späte Endosomen und Autophagosomen in den Hepatozyten der kleinen Vti1b-defizienten Mäuse angereichert waren. Häufig waren die Autophagosomen in engem Kontakt …
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Funktionelle Analyse des murinen 66.3-kDa-Proteins
… mit der lysosomalen Aspartylprotease Cathepsin D, welche während der ausführlichen molekularen Charakterisierung vermutet wurde, konnte im Rahmen der vorliegenden Arbeit mit verschiedenen Interaktionsstudien (Ko-Immunpräzipitation, Pepstatin-A-Chromatographie, Vernetzung mit …
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Biomolecular ligand design : enhancing binding affinity and specificity utilizing electrostatic charge optimization and packing techniques
… and the human aspartyl proteases pepsin and cathepsin D as decoys that may help to elucidate principles for designing more selective inhibitors.
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Adrenergic control of proteolysis in brown adipocytes
… cell UCP1 content was decreased. Expression of cathepsin D (a lysosomal protease) was differentiation-dependent, but was not affected by NE. Direct estimates of turnover rates of UCP1 as well as mitochondrial translation products indicated that NE reduces the degradation of mitochondrial …
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Mode of Entry and Survival of Salmonella Enterica Serovar Typhimurium in Trophoblast Cells
… membrane protein-1 (LAMP-1) and cathepsin D). Moreover, human primary cTBCs harboring S.Tm underwent rapid death of the cells. Infected cTBCs expressed phosphorylated-receptor-interacting serine/threonine-protein kinase (RIPK)-1 protein and phosphorylated-mixed lineage kinase …
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Mass Spectrometric Characterization of the MCF7 Cancer Cell Line: Proteome Profile and Cancer Biomarkers
… cancer markers. Biomarkers such as PCNA, cathepsin D, E-cadherin, 14-3-3-sigma, antigen Ki-67, TP53RK, and calreticulin were identified. These data were generated by subjecting to mass spectrometric analysis ~42 µg of protein digest, analyzing 16 SCX peptide fractions, and interpreting …
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Characterizing RNA translocation in the parasitic weed Cuscuta pentagona
… tomato Gibberellic Acid Insensitive (SlGAI) and Cathepsin D Protease Inhibitor (SlPI) can be traced over 30-cm of parasite stem. SlPI was abundant in the C. pentagona stem, but the number of copies decreased substantially within the first eight hours post detachment. Additional studies of mobile …
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Evaluation of microbial adjuncts and their effect on the ripening of cheddar cheese
… paracasei DPC 4715 was sensitive to chymosin and cathepsin D and it may have been cleaved by the rennet used for the cheese manufactured or by indigenous milk proteases. A series of studies were performed using various microbial adjuncts to influence cheese ripening. Microbacterium casei DPC 5281, …
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Studies on the Structure of Human Fibronectin
… gelatin-binding polypeptide was isolated from cathepsin D digests of plasma fibronectin. This fragment was cleaved further with thrombin to produce a 43,000 dalton fragment which retained the ability to bind to gelatin and a 29,000 dalton fragment which did not. NH<sub>2</sub>-terminal analysis …
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The role of heterozygous lysosomal storage disorder alleles as risk factors for dementia
… Lysosome-associated membrane protein 1 and cathepsins B, L and D accumulated at amyloid beta plaques in AppNL-G-F/NL-G-F mice, presenting at the earliest and smallest plaques observed. AppNL-G-F/NL-G-F mice also exhibited elevated activity of β- hexosaminidase and cathepsins D/E and elevated …
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Study of drug delivery and cell encapsulation using biocompatible hydrogel
… In this study, the peptide was used to target Cathepsin D that is overexpressed by breast cancer cells. Gelatin microspheres were utilized as drug carriers which immobilized doxorubicin, an anticancer drug. Uniform gelatin particles (30 µm in diameter, dry) were fabricated via the electric …
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