Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"cataractogenesis"”.
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The role of estrogen and superoxide dismutase in cataractogenesis
… antioxidant enzyme superoxide dismutase (SOD) in cataractogenesis. Human lens epithelial cells (HLECs) obtained during cataract surgery at the Department of Ophthalmology at Sahlgrenska university hospital in Mölndal (SU/M) were used to study the effects of the major estrogen, 17β-estradiol (E2), …
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Regulation of cataractogenesis in cultured bovine lenses by hydrogen sulfide donors
… However, L-cysteine reportedly mitigates cataractogenesis, in vitro and in vivo. Here, we sought to standardize a new method for screening cataractogenesis and assess the effect of hydrogen sulfide (H2S) on cataractogenesis. Bovine lenses were cultured in DMEM with AA (positive control) or …
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Regulation of Cataractogenesis in Culture Bovine Lenses by 5-Phenyldithiole-3-Thione-NSAID Hybrid Molecules
… drugs (NSAIDs) such as ibuprofen can mitigate cataractogenesis. Therefore, this study investigated the pharmacological actions and mechanisms by which ATB 343 (indomethacin & H2S donor) and ATB 337 (diclofenac & H2S donor) regulate time-dependent and hydrogen peroxide (H2O2)-induced …
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Characterization of the unfolding, refolding, and aggregation pathways of two protein implicated in cataractogenesis : human gamma D and human gamma S crystallin
Human [gamma]D crystallin (H[gamma]D-Crys) and human [gamma]S crystallin (H[gamma]S-Crys), are major proteins of the human eye lens and are components of cataracts. H[gamma]D-Crys is expressed early in life in the lens cortex while H[gamma]S-Crys is expressed throughout life in the lens epithelial …
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Cloning and Overexpression of Yeast Cystathionine γ-Lyase
… of reactive site residues, has been linked to cataractogenesis. This research isolated the cystathionine γ-lyase gene (<i>CYS3</i>), modified it with an XhoI and BlpI restriction site and enterokinase sequence (creating a modified <i>CYS3</i>, <i>mCYS3</i>, gene), and ultimately spliced it into …
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Investigation into the lipid activation of calpain and its role in cataract formation
… of these enzymes are believed to participate in cataractogenesis. Calpain 2 is the major isoform of calpain involved in human cataractogenesis and its activation appears to be investigate the mechanism of lipid activation of calpains as an essential link towards understanding the molecular and …
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Lens calcium homeostasis and selenite cataract
… induced by selenite. The mechanism of selenite cataractogenesis involves calcium activation of calpain with subsequent proteolysis within the lens nucleus. This study was undertaken to investigate the biochemical mechanisms that lead to calcium accumulation in these circumstances. The components …
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A Pilot Study- Identify Genetic Variants for Diabetic Cataract Using GoDARTS Dataset
… with diabetic cataract. The role of genes in the cataractogenesis needs to be reevaluated in future studies. The risk and protective factors were identified with GoDARTS dataset.<br/> <br/>