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Showing 1 to 10 of 10 for “"catalytic antibodies"”.
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Amide hydrolysis by catalytic antibodies
Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1996.
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Toward catalytic antibodies capable of ergopeptine hydrolysis
… advantage and comprise over 60% of pastureland. Catalytic antibody vaccines would permit the use of endophyte-infected grasses without the risk of animal toxicoses. The production of catalytic antibodies capable of hydrolysing ergopeptine toxins was investigated. The literature pertaining to …
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Catalytic antibodies elicited via homologous and heterologous immunization
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1994.
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Catalytic antibodies for amide cleavage and prodrug activation
… a novel approach to generate amide cleaving antibodies. Two haptens, O1 and O2, were designed and synthesized to create a hydrophobic pocket for an auxiliary nucleophile as well as elicit complementary basic/acidic side chain residues in the antibody combining binding site. The recently …
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Towards the generation of catalytic antibodies for glycoside hydrolysis
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1995.
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DIRECTED EVOLUTION FOR THE DESIGN OF NEW CATALYSTS
<p>Introducing new catalytic function into existing proteins provide ways of understanding the fundamental principles of enzyme catalysis and has gained recognition as a leading tool for understanding protein folding, structure, and function. De novo computational design coupled with directed …
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Herstellung von katalytischen monoklonalen Antikörpern
… of substrates to enzymes and antigens to antibodies, respectively, antibodies with catalytic activities have been created since 1986. We have succeeded in developing the first monoclonal antibody that catalyzes a cyclic reaction to form vitamin E in a stereoselective manner. So far, …
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Antiviral activity of 3D8 single chain Fv against RNA virus infection
Catalytic antibodies against viruses have been constantly developed in preventive or therapeutic fields to target viral antigens effectively. 3D8 is an anti-DNA catalytic antibody that binds to DNA and RNA then degrades them without sequence specificity as well known as Abzymes. Previously it was …
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Versuche zur Gewinnung von katalytischen Antikörpern zur Hydrolyse von Arylcarbamaten und Arylharnstoffen
Im Rahmen dieser Arbeit gelang es, katalytische Antikörper zur Hydrolyse von Benzylphenylcarbamaten sowie zahlreiche monoklonale Antikörper gegen Haptene herzustellen. Es wurden verschiedene Hapten-Protein-Konjugate unter Verwendung unterschiedlicher Kopplungsmethoden hergestellt und …