Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"catabolic pathway"”.
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Evidence for reversible phosphorylation as a post-translational regulatory mechanism in the chlorophyll catabolic pathway
Senescence, the final developmental stage in plants, is a highly regulated degenerative process, which ultimately allows for the remobilization of nutrients within the plant from older to younger developing tissues and organs. Among the events characteristic of senescence in aerial plant tissues is …
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Systematic Survey of the Plasmodium falciparum Hemoglobin Catabolic Pathway in Intact Cells Using the Digestomics Approach
… asexual reproduction cycle. This catabolic process has been extensively studied over the past six decades as a potential target for antimalarial drugs. The current model describes Hb proteolysis as a semi-ordered process involving the concerted action of various endo- and …
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Enabling Cl-Based bioconversion with metabolic engineering
… in the desired host, or to import the relevant catabolic pathway into a more tractable organism, such as Escherichia coli. This thesis explores both options within the context of developing strains for the conversion of C1 substrates into value-added chemicals and fuels.
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In situ sintering study of model nickel catalysts
… as metabolomics tools in the study of such catabolic pathways. The development of biomarkers and internal standards to perform quantitative and qualitative analysis of metabolites in the catabolic pathway would be an attractive tool. Thus, cholesterol derivatives were synthesized as thia-, …
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Synthesis and evaluation of flouro and thia lipids as bioanalytical tools
… as metabolomics tools in the study of such catabolic pathways. The development of biomarkers and internal standards to perform quantitative and qualitative analysis of metabolites in the catabolic pathway would be an attractive tool. Thus, cholesterol derivatives were synthesized as thia-, …
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Investigating the role of ULK1 kinase activity during autophagy
Macroautophagy (hereby autophagy) is a catabolic pathway whereby a double membrane organelle called an autophagosome, engulfs cytoplasmic components in order to degrade them via the lysosome. While autophagy is induced in response to various stresses to promote homeostasis and cell survival, a key …
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Regulation of the Lipid Kinase VPS34 by mTOR-Mediated UVRAG Phosphorylation
… the protein kinase ULK1. Autophagy acts as a catabolic pathway that is up regulated in response to stress, but is negatively regulated by the master growth protein kinase mTOR. This study sought to identify novel control mechanisms that may mediate the regulation of VPS34 between the pathways …
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Interrogating Cancer Metabolism using Novel Imaging Techniques
… 1 (BCAT1), the first enzyme in the catabolic pathway of Branched Chain Amino Acids. This enzyme is upregulated in many cancers and is linked to cancer progression. In this project, the role of BCAT1 in cell proliferation was confirmed in glioblastoma patient derived cells and tumours …
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A kinetic and equilibrium description of camphor hydroxylation by the P450cam monoxygenase system
Camphor is hydroxylated in the soil bacterium Pseudomonas putida by a soluble three protein monoxygenase system consisting of (1) a NADH-specific FAD flavoprotein reductase, (2) a Fe2S*2 Cys4 iron-sulfur redoxin termed putidaredoxin (Pd) and (3) cytochrome P450cam, abbreviated cytochrome m for …
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Differential Autophagic Responses to Nano-Sized Materials
… the lysosome-autophagy system, which is the main catabolic pathway in mammalian cells that mediates degradation of a variety of nano-sized materials that are encountered by the cell through the lysosome. The lysosome-autophagy system is thus at the forefront of the cellular response to the uptake …
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Deoxyribophosphoaldolase of human erythrocytes: identification, purification and characterization
… substrates and may, in fact, provide a major catabolic pathway for the deoxypentose moiety of these deoxynucleosides. The enzyme provides a simple mechanism for triosephosphate formation from deoxypentose and may be part of a pathway that converts deoxypentose phosphate to pentose phosphate.
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Elucidating the role of jasmonate metabolites in jasmonic acid signaling
… gene expression. Although the JA biosynthetic pathway is well known with almost all the biosynthetic enzymes identified and characterized in detail, the catabolic pathways leading to a diverse array of JA metabolites has only begun to be studied in recent years. One of those pathways catalyzed …