Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"castration resistance"”.
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Prostate Cancer Stem Cells: Drug to lerance, Experimental Reconstitution and Castration Resistance
… progression, recurrence, metastasis and therapy resistance. Like CSC studies in other cancer types, it has been reported that PCa also contains CSCs. However, there remain several unresolved questions that need to be clarified. <em>First</em>, the relationship between prostate CSCs (PCSCs) and …
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The role of BET proteins in castration-resistant prostate cancer dissemination
… progression of advanced prostate cancer to castration resistance, and ultimately to lethal metastatic disease, depends on primary or acquired resistance to conventional androgen-deprivation therapy (ADT) and accumulated resistance mechanisms to evade androgen receptor (AR) suppression. …
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The role of SRC family kinases in the development and progression of prostate cancer
… and metastatic prostate cancer consists of castration therapy, which suppresses the development of the disease for 2 years in average. Virtually all patients, undergoing androgen deprivation therapy eventually develop castration-resistant prostate cancer. Currently, only taxane class of …
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Androgen Receptor and Prostate Cancer Cell Heterogeneity
… is heterogeneous in both primary PCa and castration resistant prostate cancer (CRPC). However, the functional significance of AR heterogeneity in regulating PCa biology and response to androgen/AR-targeted therapies remains unclear. The overarching hypothesis for my Ph.D is that <strong>AR …
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Integrative Bioinformatics Approaches to Elucidating Prostate Cancer Cell Heterogeneity, Plasticity, and Treatment Response
… present in primary tumors and become enriched in castration resistant PCa (CRPC). Our lab has demonstrated that the prostate cancer stem cells (PCSCs) are enriched in the phenotypically undifferentiated PCa cell population that lacks the expression of differentiation marker prostate-specific …