Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 112 for “"castration"”.
-
Chemoligand therapy for metastatic castration-resistant prostate cancer
… disease of >70% of patients with metastatic castration-resistant prostate cancer (mCRPC) has moderate to high nonphysiological levels of a transmembrane protein known as prostate-specific membrane antigen (PSMA) and creates opportunities for precision medicine approaches. Using PSMA as a …
-
Characterizing glucocorticoid receptor in metastatic castration resistant prostate cancer
The purpose of this paper is to characterize the glucocorticoid receptor (GR) signaling and relevance in the context of enzalutamide resistant prostate cancer cells. Enzalutamide is a drug that functions to dampen androgen receptor (AR) signaling, thus inhibiting cancer dependency on the receptor …
-
Cattle behavioral responses following castration and dehorning measured by accelerometers.
Castration and dehorning are common husbandry practices in the United States. The objective of this research was to evaluate behavioral responses to these painful procedures. Two studies were conducted using three dimensional accelerometers to measure behavioral differences in cattle following …
-
The role of BET proteins in castration-resistant prostate cancer dissemination
… progression of advanced prostate cancer to castration resistance, and ultimately to lethal metastatic disease, depends on primary or acquired resistance to conventional androgen-deprivation therapy (ADT) and accumulated resistance mechanisms to evade androgen receptor (AR) suppression. …
-
Surgical castration in piglets: its impacts on pain and affective states
Surgical castration of young male piglets is an extremely common husbandry procedure in the United States swine industry, with nearly 100% of males castrated. The procedure is performed primarily to prevent the occurrence of boar taint in the meat and to reduce aggression as the animals age. No …
-
Therapeutic Effects and Targeted Delivery of Eupenifeldin in Castration-Resistant Prostate Cancer
Castration-resistant prostate cancer (CRPC) poses a major therapeutic challenge, as it often fails to respond to standard treatments such as taxane-based chemotherapies, androgen receptor pathway inhibitors, and radioligand-based approaches1–4. Despite these treatments, CRPC remains incurable, and …
-
Prostate Cancer Stem Cells: Drug to lerance, Experimental Reconstitution and Castration Resistance
… of PCa from androgen dependent to the lethally castration resistant (CRPC) stage remains enigmatic, and the cells responsible for CRPC development have not been identified. Herein, we have found a putative cell population, ALDH<sup>+</sup>CD44<sup>+</sup>α2β1<sup>+</sup> PCa cells that may …
-
BOTH EFFECTOR AND INHIBITORY IMMUNE MECHANISMS ARE AMPLIFIED IN CASTRATION-RESISTANT PROSTATE CANCER
… tumor antigen were transiently enhanced after castration in a prostate tumor model. We also observed a parallel amplification of CD4+CD25+FoxP3+ regulatory T cells (Tregs) in the prostate draining lymph nodes and spleens of castrated tumor bearing mice, which was completely abrogated by IL-2 …
-
Decoding the RNA cargo of plasma-derived extracellular vesicles in metastatic castration-resistant prostate cancer
… observational trial cohort of metastatic castration-resistant prostate cancer (mCRPC) patients, treated with Enzalutamide in a chemo-naïve setting. Specifically, it incorporates EV physical characterization, EV-RNA and matched cfDNA genomics. The use of total RNA sequencing (RNA-seq) …
-
TMEFF2 is an epigenetic modulator that promotes androgen independent growth in castration-resistant prostate cancer cells
… of patients relapse with currently untreatable castration resistant prostate cancer (CRPC), during which the PCa cells develop the ability to grow in androgen depleted conditions. The androgen receptor (AR) plays a vital role in prostate development and homeostasis, and the deregulation of AR …
-
Role of the extracellular matrix-integrin interaction in enzalutamide resistance of bone metastatic castration-resistant prostate cancer
Bone metastatic castration-resistant prostate cancer (bone mCRPC) is the most prevalent type of prostate cancer metastasis, accounting for 90% of all metastasis incidence. Its resistance to androgen-deprivation therapy (ADT). Enzalutamide (Enz) is a second-generation androgen-receptor (AR) …
-
Effect of immunological castration on color stability, shelf life, and sensory characteristics of fresh and further processed pork
… blocking its activity and causing temporary castration. Use of Improvest delays castration, taking advantage of increased feed efficiency and lean gain of intact male pigs, without the negative sensory characteristics associated with boar taint. Fresh loin muscle quality has been extensively …
-
Chemical Castration: How a Medical Therapy Became Punishment and the Bioethical Imperative to Return to a Rehabilitative Model for Sex Offenders
Chemical castration is a colloquial term used to refer to the treatment of certain sex offenders with antiandrogenic drugs in order to reduce recidivism. The use of this treatment began in the United States in 1966, at which time the nation favored a rehabilitative approach to criminal justice. In …
-
Immunological castration of boars temporarily reduces testosterone concentration, testis size and function, without long term effects on libido and sperm quality
… objective was to determine the effects of immunocastration (Improvest) on reproductive characteristics in boars. Seventy-two boars were used in a randomized design with three treatments: single injection (SI) or double injection (DI) of Improvest, and intact controls (no Improvest; CNT) (n = …
-
CRISPR/Cas9 screenings and in silico investigations nominate low-frequency alterations in DNA repair genes as biomarkers for castration-resistant prostate cancers.
… with therapeutic response in metastatic castration-resistant prostate cancer (mCRPC) patients characterized by defects in homologous recombination repair genes. Clinical trials results suggest that further improvements are possible, for instance in terms of patients’ enrolment criteria. …
-
The role of SRC family kinases in the development and progression of prostate cancer
… and metastatic prostate cancer consists of castration therapy, which suppresses the development of the disease for 2 years in average. Virtually all patients, undergoing androgen deprivation therapy eventually develop castration-resistant prostate cancer. Currently, only taxane class of …
-
An Investigation of Hair Cortisol as a Biomarker of Long-Term Stress in Beef Cattle
… procedures that occur in modern production: i) castration, and ii) weaning in order to study HC concentration as an objective measure of long-term stress, and explore various factors that influence HC concentration such as sex, temperament, dam parity and calf age. For study 1, bull calves …
-
Analyzing the Management Practices of East Texas Beef Cattle Producers
… A negative correlation was established between castration method and weaning weight (p = - 0.204). Calves were weaned 50 pounds heavier when band or surgically castrated. Females were less likely to castrate their calves or utilize a mineral program. Approximately, 49.5% of producers did not …
-
Androgen Receptor and Prostate Cancer Cell Heterogeneity
… is heterogeneous in both primary PCa and castration resistant prostate cancer (CRPC). However, the functional significance of AR heterogeneity in regulating PCa biology and response to androgen/AR-targeted therapies remains unclear. The overarching hypothesis for my Ph.D is that <strong>AR …
-
Mechanisms of Estrogen-Dependent Dendrogenesis in Motoneurons of the Spinal Nucleus of the Bulbocavernosus
… ERα expression is sensitive to gonadal hormones: Castration dramatically upregulates the density of extra-muscle fiber cell ERα. Brief estradiol treatment during heightened ERα expression results in rapid, robust dendritic growth, suggesting that the estrogen sensitivity of SNB dendrites is …
Page 1 of 6