Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"castrate"”.
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Analyzing the Management Practices of East Texas Beef Cattle Producers
… weaned 50 pounds heavier when band or surgically castrated. Females were less likely to castrate their calves or utilize a mineral program. Approximately, 49.5% of producers did not pregnancy check their cattle. Areas of future education should focus on castration and weaning methods, mineral …
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HDAC inhibition results in suppression of FOXM1 and genes associated with poor prognosis prostate cancer through p53 dependent and independent mechanisms
… of advanced prostate cancer and metastatic castrate resistant disease, our data demonstrates that the Class I HDAC inhibitor, Entinostat, augments the effects of both the p53 activating MDM2 inhibitor, Nutlin-3A and radiotherapy, resulting in a synergistic induction of cell death dependent …
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Diethylstilbestrol Nanosuspensions for Prostate Cancer: Subcutaneous Sustained Release Formulations and Pre-clinical PK/PD Evaluations
… (DES) was mainstay treatment for metastatic and castrate resistant prostate cancer for half a century. In the mid-1980s its use was drastically reduced because of its severe cardiovascular toxicity and thromboembolic complications such as deep vein thrombosis, pulmonary embolism and heart attack. …
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CaV1.3 Ion channel expression and hormone therapy in prostate cancer
… (AR) antagonists, e.g. Enzalutamide (ENZ). Castrate-resistant disease, where tumours become resistant to hormone therapy, is characterised by limited effective treatments and poor survival outcomes. The aberrant expression and function of ion channels in the oncology field has been …
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The Development of Gene Therapy by way of DNAzymes, and a Computational Tool that Predicts Efficient DNAzymes.
… development of this novel therapeutic for castrate resistant prostate cancer and opens up DNAzymes as a possible gene therapy, deliverable by DNFs, for many other diseases where there is currently an unmet clinical need. Further, the parameters identified will allow for the computational …
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Characterisation of Androgen Receptor Variants in Breast Cancer and the Development of Thieno[2,3-b] Pyridines as Novel Anti-Cancer Compounds
… fail and the tumours progress to the aggressive castrate resistant stage of the disease. Thieno[2,3-b]pyridine derivatives have been previously demonstrated to be effective inhibitors in BCa. Here we expanded the research by investigating the efficacy of these compounds upon PCa. Using growth …
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Characterisation of Androgen Receptor Signalling and Metabolism in Prostate Cancer
… to an aggressive, incurable stage known as castrate-resistant prostate cancer (CRPC), for which very few therapies exist. Therefore, understanding and characterising AR signalling may aid in the development of novel therapeutics. Fused in Sarcoma (FUS) (a co-regulator protein of the AR) and …
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The tabloid Trickster: a post-Jungian evaluation of early 21st century popular British newspaper journalism characterised by that of The Sun
… that UK statutory press regulation would ‘castrate’ the tabloid Trickster, rendering it unable to perform its psychosocial function, to the detriment of a society already challenged by a fragmenting post-modern media landscape.
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Study of the androgenic activity of the regenerating adrenal cortex.
… the dorsolateral prostate. Acclimated intact and castrated animals were used as well as animals with regenerating cortices (bilateral - adrenal - enucleated) and dual operations (enucleation - castration). At room temperature (22°C), the intact and enucleated appeared similar in androgen level …
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Effects of Respiratory Vaccination Timing and Hormonal Growth Implant on Health, Performance, and Immunity of Newly Received Stocker Calves
… (initial BW = 202 ± 4.1 kg), stratified by castrate status on arrival, and assigned randomly to 1 of 4 treatments arranged in a 2 × 2 factorial: 1) arrival (d 0) vaccination, with implant (AVACIMP), 2) arrival vaccination, without implant (AVAC), 3) delayed (d 14) vaccination, with implant …
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Significance of Increased Tissue Transglutaminase In Hormone Refractory Prostate Cancer
… cancer cells exhibit resistance not only to castrate levels of testosterone, but also to other therapeutic modalities and hence become lethal. Currently, there is no effective treatment available for managing this cancer. These observations underscore the urgency to investigate mechanism(s) …
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Integration of class 1 HDAC inhibitors into current treatments for prostate cancer
… therapies results in progression to incurable castrate resistant prostate cancer (CRPC). Androgen signalling inhibitors (ASI), including Enzalutamide (ENZ) and Abiraterone (ABI), are effective treatments for metastatic CRPC however, resistance develops within 24-months of initial exposure in …
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The role of sphingosine kinases and dihydroceramide desaturase in regulating senescence in prostate cancer cells
… a series of SK inhibitors in an advanced stage castrate resistant prostate cancer cell line (LNCaP AI cells). The current study demonstrated that dual inhibition of SK1 and SK2 as well as knockdown of an additional target up stream in the sphingolipid signalling pathway - dihydroceramide …
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An innate immune response to DNA damage in prostate cancer
… core biopsies were obtained from 52 men with Castrate Resistant Prostate Cancer (CRPC) treated with docetaxel in the NI Cancer Centre. Samples were microarray profiled, signature scored and defined as DDRD positive or negative.<br/><br/>Results<br/>siRNA mediated knockdown of BRCA1, BRCA2 and …
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Characterisation of calcium/calmodulin-dependent protein kinase kinase 2 in prostate cancer
… therapeutic target in androgen responsive and castrate resistant disease but the only commercially available inhibitor, STO-609, exhibits promiscuity and direct inhibition of AMPK. Thus, to progress the understanding and druggability of CaMKK2 in PCa we investigated novel interactors and …
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Impact of dietary tomato intake on prostate cancer throughout the course of disease development and progression in a transgenic mouse model
… or lycopene impacted the molecular expression of castrate-resistant tumors. In two independent studies using ultrasound imaging to monitor in vivo tumor growth, we previously showed that neither dietary tomato nor supplementation of its primary bioactive, lycopene, inhibited the emergence or …
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The Epigenetics of Small Cell Prostate Cancer
<p>Small cell prostate cancer (SCPC) is an androgen receptor (AR) negative variant that can develop during the progression of castration-resistant AR-positive (AR<sup>+</sup>) prostate adenocarcinomas. While rare at initial diagnosis, SCPC is present in 10-20% of patients resulting in an aggressive …
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Gender, text, and the body in Martial’s Epigrams
The expression “body of work” has long been used to describe the creative output of an author or artist, and the Latin word corpus is traditionally used to signify the bulk of a textual work because it represents a whole being made of many parts. This dissertation explores Martial’s Epigrams to ask …