Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"caspase-independent"”.
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Thioredoxin-1 Inhibition Promotes MLKL Activation: Biochemical Insights Into a Suppressor of the Necroptotic Pathway
Necroptosis is an immunogenic caspase-independent cell death program. While mainly serving to defend against viral infection, dysregulated necroptotic signaling contributes to the pathology of a growing number of human diseases associated with inflammation, neurodegeneration, and ischemic injuries. …
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Novel Protein-protein Interactions Regulate The Proteolytic Activity Of The Pro- Apoptotic Serine Protease, Omi/htra2
… to the bacterial HtrA proteins. Omi promotes caspase-dependent apoptosis by binding and degrading IAPs-inhibitor of apoptosis proteins. Omi can also induce caspase-independent apoptosis but the actual mechanism is still unknown. IAP's are not the only substrates cleaved by Omi. There are at …
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Nanosecond Pulsed Electric Field Induction of Programmed Cell Death Is Cell Type Dependent: An <i>in vitro</i> Study
… deficient in FADD (ΔFADD) and deficient in caspase-8 (ACas-8). The overall hypothesis is that nsPEFs eliminate cancer cells through activating caspase-dependent and caspase-independent programmed cell death pathways that originate from plasma membranes and/or intracellular membranes, …
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Synergism of Gingipains in Endothelial Cell Adhesion Disruption and Apoptosis
… events, including Annexin-V positivity, caspase-3 activation, and cleavage of the caspase substrates poly(ADP-ribose) polymerase (PARP) and Topoisomerase I (Topo I) were observed in endothelial cells after detachment. We have demonstrated that Kgp activity can be inhibited by synthetic …
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Arsenic trioxide in ovarian cancer
… treatment caused both apoptosis induction and caspase-independent cell death involving mitochondrial dysfunction. This was accompanied by endoplasmic reticulum stress induction and an increase in intracellular glutathione (GSH) level. The latter was in turn prevented by the concurrent use of …
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Apoptosis and Necroptosis in Renal Cell Carcinoma // Апоптоза и некроптоза при бъбречноклетъчен карцином
… occur via another, alternative pathway that is caspase-independent and involves AIF. The role of AIF in renal cell carcinoma is poorly studied and additional research is needed, which is why it was the object of the present study. Another form of cell death is necroptosis. A key participant in …
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Estrogen Receptor -Dependent and Estrogen Receptor-Independent Pathways for Tamoxifen and 4-Hydroxytamoxifen-Induced Programmed Cell Death
… cell death through distinct ER-dependent and ER-independent pathways. The ER-independent pathway requires 10--20 muM TAM or OHT and occurs in ER-negative cells. Nanomolar concentrations of OHT activate an ER-dependent pathway. 17beta-estradiol, raloxifene, and ICI 182,780 are all effective …
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Biochemical and Cellular Characterization of NMN Adenylyltransferase 2: A Brain Specific Isoform of an Essential NAD Synthesizing Enzyme
… This phenotype requires Nmnat activity and is caspase-independent suggesting that neuronal NAD metabolism regulates a novel program of self-destruction in axons. Nmnat2 is detected exclusively in the brain, unlike Nmnat1 and Nmnat3, which are widely expressed. Furthermore, Nmnat2 localizes to …
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Characterization Of A Novel Interactor/substrate For The Pro-apoptotic Serine Protease Omi/htra2
… In the cytoplasm Omi participates in both the caspase-dependent as well as caspase-independent apoptosis. Additionally, recent studies suggest that Omi may have another unique function, maintaining homeostasis within the mitochondria. In an effort to further elucidate the function of Omi, a …
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The development of a novel therapeutic strategy for the treatment of prostate cancer by targeting metabolic signalling
… was found to significantly induce caspase-independent cell death and to sensitise cells to ROS. Importantly, the inhibitory activity of succinylacetone in combination with ROS showed specificity for cancer cell lines. Targeting heme synthesis therefore represents a novel targeted …
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A Novel Cardiac Function of Sumo2/3 and Senp5 Dependent Pathway and Its Physiological Impact On Congestive Cardiomyopathy
… have been known to be involved in mitochondrial-independent cell death pathway in heart. These SUMOylations of Calpain2 and Calpastatin facilitate activation of Calpain2 by reducing inhibitory role of Calpastatin. These findings identify a SUMO2/3-dependent modification as a novel …
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Investigating inhibition of porphyrin (heme) synthesis as a novel treatment option for prostate cancer
… demonstrated that SA induced a low level of caspase independent cell death, but when combined with ROS damage the percentage number of cells undergoing cell death increased significantly. The data suggest that cell death is not as a result of apoptosis, necroptosis or ferroptosis, suggesting …
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Studies on Taxol Resistance Induced by HBx Viral Oncoprotein
… celldeath in Chang cells was triggered by caspase-independent cell death pathways. In contrast, celldeath in ChangX-31 and ChangX-34 was occurred by caspase-dependent cell death pathways. In addition, we found sulfasalazine, inhibitor of NF-κB activation, significantly increased cell death …
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Development of poly(ADP-ribose) glycohydrolase inhibitors and tetracyclic indoles as anticancer compounds
… of endoplasmic reticulum stress leading to caspase-independent cell death.
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Design, synthesis and biological evaluation of sphingosine kinase inhibitors for the treatment of prostate cancer
… cancer cell death, which was shown to involve a caspase-3/7-independent mechanism. Our SK1 and SK1/SK2 inhibitors, but not SK2 inhibitors, also reduced expression of dihydroceramide desaturase 1 (Des1) in a dose dependent manner, causing growth arrest and caspase-independent cell death. This …
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Regulation of Histone Covalent Modifications During Yeast Apoptosis
… Mst1, Ste20 translocates into the nucleus in a caspase-independent fashion to mediate phosphorylation of H2B. H2BS10ph is dependent on the removal of acetylation mark on adjacent lysine residue, (H2BK11ac), which exists in growing yeast. During yeast apoptosis, the HDAC Hos3 deacetylates K11, …
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A New Type of Programmed Cell Death in C. Elegans
… and by a requirement for the activity of caspase proteases, which are controlled by conserved gene pathways. Although non-apoptotic, caspase-independent programmed cell death pathways have been postulated, there is little evidence to convincingly prove their existence, and few insights …
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Components of the Ubiquitin Proteasome System are Required for the Nonapoptotic Death of the C. Elegans Linker Cell
… events cannot be accounted for solely by caspase-dependent apoptosis, yet, alternate pathways are poorly understood. Direct evidence that caspase-independent non-apoptotic cell death pathways operate during animal development is provided by studies of the C. elegans linker cell. Genetic …
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Novel Protective Agents against Cerebral Ischemia/Reperfusion Injury.
… More importantly, Nec-1 inhibited BNIP3-mediated caspase-independent cell death. Cerebral ischemia/reperfusion injury involves the activation of different pathways that lead to neuronal cell death. Given this multifactorial pathnogenesis, it is possible that a cocktail of neuroprotective agents …
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A chromatin-modifying protein is a context-dependent modulator of cell survival in hematopoietic malignancies
… cells leads to cell death, most likely in a caspase-independent manner and without a preceding cell cycle arrest. While multiple kinds of B cell malignancies were dependent on CHD8 expression for survival, two T cell malignancies displayed significantly milder phenotypes upon CHD8 knockdown. …
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