Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"caspase-4"”.
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Entamoeba histolytica-Induced Caspase-4 Activation Regulates IL-1β Secretion Through Caspase-1
… EhCP-A5 ligates α5β1 integrin to activate caspase-1 in a complex known as the NLRP3 inflammasome. In this study, we investigated the parasite requirements underlying macrophage caspase-4 and -1 activation and the role caspase-4 play in augmenting pro-inflammatory cytokine responses. …
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Entamoeba histolytica-induced Activation of Caspase-4 Regulates Gasdermin D Cleavage to Mediate IL-1β Secretion in Macrophages
… Eh in direct contact with macrophages activates caspase-1 by the assembly of the NLRP3 inflammasome complex in a Gal-lectin and EhCP-A5-dependent manner, resulting in the maturation and secretion of IL-1β and IL-18. Pyroptosis, an inflammatory mode of lytic programmed cell death, is essential for …
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Examining the Role of Non-Canonical NOD-like Receptors and Inflammasomes in Inflammation and Disease
… proteins responsible for the activation of caspase-1 and the maturation and secretion of the pro-inflammatory cytokines IL-1β and IL-18. In contrast, the non-canonical inflammasome-independent NLRPs regulate a variety of other pathways, including MAPK and NF-κB, through the formation of …
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Elucidating Human Inflammasome Responses To Legionella Pneumophila And Lipopolysaccharide Variants
… the recruitment and activation of inflammatory caspases. These caspases promote IL-1 family cytokine release and pyroptosis, a lytic form of cell death, which are critical for anti-bacterial defense. In mice, interferon-gamma (IFN-) is a potent inducer of the both the noncanonical and canonical …
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Human enteroids as a model for infectious disease
… Interestingly, IL-18 secretion is dependent on caspase-4, but not caspase-1 or caspase-5. Additionally, lack of caspase-4 in human enteroid monolayers resulted in increased intracellular colony forming units and increased numbers of intracellular bacteria per cell. These data indicate that …
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The role of IFN-γ in cell-autonomous immune responses against Salmonella Typhimurium and Toxoplasma gondii
… bacteria and is sensed in the cytosol by human Caspase-4. The research described in Chapter 2 used a genome-wide CRISPR-Cas9 screen as an unbiased approach to identify new IFN-γ-induced genes that play a role in the cell death pathway. This viability screen enriched for cells resistant to …
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Inflammasomes in the Intestinal Epithelium
… of pathological stimuli to activate inflammatory caspases, resulting in cell death and the release of IL-18 and IL-1. Inflammasomes are important in a wide range of diseases, in particular with auto-inflammatory disorders in humans. While they have been extensively studied in immune cells, their …
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Caspase isoforms in inflammasome activation
… NLRP3 or NLRC4), an adaptor (ASC) and effectors (caspases) that are thought to play critical roles in the host defence against microbial infections. Activation of inflammasomes leads to the processing of the pro-inflammatory cytokines pro-IL-1β and pro- IL-18 to their active form and cleavage of …
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Fatty Acid Regulation of NLRP3 Inflammasome Activity
… also the non-canonical inflammasome components caspase-4/5/11. Disruption of either pathway leads to partial impairments in the inflammasome response to PA, though the canonical pathway generally accounts for more IL-1 secretion while the non-canonical pathway is the primary driver of cell …