Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"caspase-2"”.
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The Role and Regulation of Caspase-2 in Lipoapoptosis
… death that promote this transition.</p><p>Since caspase-2 has been reported to respond to different types of intracellular metabolic stress to promote apoptosis, we investigated whether this enzyme promotes lipid-induced apoptosis, or lipoapoptosis, in tissue culture cells. We discovered that the …
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TRAF Regulation of Caspase-2-Dependent Apoptosis in Response to DNA Damage
… of the spindle checkpoint.</p><p> The protease caspase-2 has previously been shown to be an important regulator of DNA damage-induced apoptosis. In unstressed cells caspase-2 is present as an inactive monomer, but upon sensing a stress caspase-2 dimerizes and becomes catalytically active. The …
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Epitranscriptional Control of the Caspase-2—MDM2—p53 Axis: The Role of the m6A Writer in p53 Signaling.
… p53 tumor suppressor pathway, acting through the Caspase-2–MDM2–p53 signaling axis, provides a crucial surveillance mechanism that detects centrosome aberrations and prevents the propagation of genomically unstable cells. Despite significant progress in understanding the proteolytic events driving …
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Discovery of a Novel Signaling Circuit Coordinating Drosophila Metabolic Status and Apoptosis
… death executed by a group of proteases named caspases, which collectively ensure tissue homeostasis in multicellular organisms by triggering a program of cellular "suicide" in response to developmental cues or cellular damage. </p><p>Accumulating evidence suggests that cellular metabolism …
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Metabolic Regulation of Cellular Signaling
… and downstream inhibitory phosphorylation of caspase-2, suppressing apoptosis. In this dissertation, we questioned whether there are other CaMBD containing proteins metabolically regulated by CoA. In an unbiased approach, CaM binding proteins were first isolated from Xenopus extract using a …
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The functional microRNA landscape of mammalian development
… cluster or knockdown of two novel targets, Caspase 2 and Ei24, could partially restore cell survival after DNA damage, implicating them as important players in a larger stress-responsive ES network under miRNA control. To better understand changes in miRNA and target repertoires at a global …
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Investigating Apoptosis Pathway In Chronic Lymphocytic Leukemia: Stromal Influence and Therapeutic Activation
… of apoptosis such as Bcl-2, IAPs, NF-kB, Caspase, TNF receptor superfamily (TNFRSF), Death Domain (DED) and Caspase Activation and Recruitment Domain (CARD) families using “real-time PCR apoptosis array-card”. While shorter incubations with supporting stromal cells induced significant …
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Multiplexed biochemical imaging reveals the extent and complexity of non-genetic heterogeneity in DNA damage-induced caspase dynamics.
… key enzymes in DNA damage-induced cell death, caspase-2, -3, and -9. We confirm the heterogeneous nature of Cisplatin-induced cell death in genetically identical cells but reveal the existence of at least three subpopulations of cells characterized by distinct caspase dynamics. By combining …