Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"caspase inhibitor"”.
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Development of a synthetic route to aminofluorohexenones as precursors for novel caspase inhibitors
… In cancer cells, a family of proteases called caspases, is involved in one or more of the signaling pathways leading to apoptosis. To better understand this cellular mechanism at the molecular level, selective inhibition of each caspase would allow scientists to determine the exact function of …
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Characterization of the vaccinia virus M1 protein on caspase inhibition and the MVA/5.2KB virus on immunogenicity
… and characterization of the VACV M1 protein as a caspase inhibitor and (ii) investigating a previously unexplored method to alter the immunogenicity of the attenuated VACV MVA. One anti-viral host response inhibited by VACV during infection is apoptosis. The attenuated MVA strain of VACV, however, …
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Overexpression of Amyloid Precursor Protein Induces Mitochondrial Oxidative Stress and Activates the Intrinsic Apoptosis Pathway
… with a DsRed-APP fusion construct displayed caspase-3 activation and nuclear fragmentation indicative of apoptosis. APP-induced apoptosis was blocked by a pan-caspase inhibitor, (BOC), glutathione (GSH), or co-expression of Bcl-2. APP caused depletion of mitochondrial GSH, induced opening of …
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The synergistic interaction between CD20 monoclonal antibodies and Histone Deacetylase inhibitors in B cell Non Hodgkin’s Lymphoma
… Non Hodgkin’s<br/>lymphoma. Histone deacetylase inhibitors are a novel class of anti cancer<br/>agents targeting epigenetic regulation.<br/><br/>This thesis addresses the interaction between histone deacetylase inhibitors<br/>and anti-CD20 monoclonal antibodies, including Rituximab, both in vitro …
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Caspase-dependent Signaling as an Inductive Cue for Cardiac Hypertrophy
… we describe an essential role for apoptotic caspase-dependent signaling in the induction of pathological cardiac hypertrophy. Initially, we discovered that primary cardiomyocytes treated with hypertrophy agonists display transient activation of intrinsic-mediated apoptotic-signaling, …
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Targeting LEDGF/p75 to Sensitize Chemoresistant Prostate Cancer Cells to Taxanes
… While TRAIL induced apoptotic blebbing, caspase-3 processing, and apoptotic LEDGF/p75 cleavage, which leads to its inactivation, in both taxane- resistant and -sensitive PC3 and DU145 cells, treatment with DTX and CBZ failed to robustly induce these signature apoptotic events. Also, …
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THE INHIBITOR-OF-APOPTOSIS PROTEIN SURVIVIN INCREASES P34CDC2 PHOSPHORYLATION AND ENHANCES CELL SURVIVAL AND PROLIFERATION BY PROTECTING THE WEE1 KINASE FROM DEGRADATION BY CASPASE-3
… alone. Treatment of control BaF3 cells with the caspase-3 inhibitor Ac-DEVD-CHO increased both Cdc2-Tyr15 phosphorylation and Wee1 protein levels. In a similar fashion over-expression of wt-Survivin in these cells maintained high levels of Tyr15 phosphorylated Cdc2 and Wee1 protein. In MCF7 human …
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Presence and Role of Acanthamoeba in Wound Infections
… and mesenchymal stem cells (MSC) using a general caspase inhibitor. The results revealed that the ability of live bacteria to induce cell death was higher compared with heat-killed bacteria, bacteria conditioned medium (BCM) and Acanthamoeba conditioned media (CM). The exact trigger for the cell …
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A New Type of Programmed Cell Death in C. Elegans
… and by a requirement for the activity of caspase proteases, which are controlled by conserved gene pathways. Although non-apoptotic, caspase-independent programmed cell death pathways have been postulated, there is little evidence to convincingly prove their existence, and few insights …
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The Characterization of a Novel Complex Implicated in the Initiation of Apoptosis
… proteins. We observed that XIAP, the main caspase inhibitor in mammals, is recruited to a 5Mda complex as early as 30 minutes after stimulation of apoptosis. Furthermore, the recruitment of XIAP to the complex is dependent on the pro-apoptotic protein ARTS, as XIAP is not recruited to the …
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Effect of Combination of Aspirin and TRAIL in HeLa Cervical Cancer Cells
… apoptotic cell death in HeLa cells. It activated caspase-8, -9 and -3 and caused the caspase-dependent loss of MMP and the release of cytochrome c from mitochondria to cytosol. The apoptotic characteristics enhanced by the combined treatment were inhibited by a pan-caspase inhibitor z-VAD-fmk. …
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SMAC Mimetics Sensitize HIV-Infected Cells to MG1-Mediated Death
… second mitochondria derived activator of caspases (SMAC) mimetic (AEG 40730, LCL-161, birinapant) to kill the latently HIV-infected lymphocytic cell line J1.1 and myelocytic cell line OM10.1. In HIV-infected cell lines, it was shown that the order of administration of MG1 and SMAC mimetics …
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Characterization of Cytotoxicity against Cancer Cells induced by Human Monoclonal Antibody Specific to TRAIL-R1
… staining and DNA fragmentation assay. Caspase activation was measured by Apo-ONE caspase3/7 Assay kit, and cleavage of caspase-3 and PARP were detected by immunoblotting. To investigate mechanisms of DR4-4 Fab-induced cytotoxicity, cytotoxicity of DR4-4 Fab was analyzed in various …