Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"caspase activation"”.
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Characterization of three Drosophila melanogaster regulators of programmed cell death that lead to caspase activation
… deaths during development, can help activate caspases in vitro, and appears to aid in the activation of procaspases overexpressed in the Drosophila eye. Interestingly, like reaper, hac-1 transcription is rapidly upregulated in response to UV and X-irradiation. An essential regulator of …
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Genetic and Biochemical Analyses of the Necessity for Caspase Activation by the CED4-Domain Proteins, APAF-1 and DARK
Activation of caspase proteases by Ced4 domain proteins is a critical step in the induction of programmed cell death, or apoptosis. Understanding of the genetic and biochemical regulation of the mammalian Ced-4 gene, Apaf-1, may be crucial to the understanding of autoimmune diseases, …
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Biochemical Pathways in Apoptosis
Caspases are a family of proteases that once activated execute apoptosis, a cellular suicide pathway. Activated caspases have a unique property to cleave and activate themselves. Once the first caspase is activated, it generates a chain reaction resulting in robust caspase activity and rapid death. …
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Genetic and molecular studies of cell-autonomous execution during programmed cell death in C. elegans
… death is a cell-autonomous process driven by the caspase family of cysteine proteases. The discovery of the CED-3 caspase in C. elegans led to the paradigm that caspase cleavage of substrates drives cell death and promotes engulfment. While many caspase substrates have been identified, it is not …
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Mechanisms of Controlled Proteolysis during Drosophila Spermatogenesis: Coordinate Action of Apoptotic Caspases and the Ubiquitin-Proteasome System
… for understanding apoptosis regulation is the activation of its primary executioner: the caspase. This family of proteolytic enzymes has been shown to be tightly controlled, as many different proteins govern their transcription, stability, activation, and activity. Consequently, caspase …
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Single-cell reporters for inflammatory caspase activity
Caspases are a 12-member family of human proteases that regulate apoptosis and inflammation. They serve as key effectors downstream of diverse signaling receptors and shape cell fate. Inflammatory caspases mediate the proteolytic processing of inflammatory cytokines and are essential in maintaining …
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Nanosecond Pulsed Electric Field Induction of Programmed Cell Death Is Cell Type Dependent: An <i>in vitro</i> Study
… deficient in FADD (ΔFADD) and deficient in caspase-8 (ACas-8). The overall hypothesis is that nsPEFs eliminate cancer cells through activating caspase-dependent and caspase-independent programmed cell death pathways that originate from plasma membranes and/or intracellular membranes, …
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Effect of Combination of Aspirin and TRAIL in HeLa Cervical Cancer Cells
… apoptotic cell death in HeLa cells. It activated caspase-8, -9 and -3 and caused the caspase-dependent loss of MMP and the release of cytochrome c from mitochondria to cytosol. The apoptotic characteristics enhanced by the combined treatment were inhibited by a pan-caspase inhibitor z-VAD-fmk. …
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Islet Dysfunction In Diabetes
… reticulum [ER] - mitochondria axis, executioner caspases and their target substrates; specifically nuclear lamins. </p> <p>Results obtained from our studies in pure beta cells [INS-1 832/13], primary rodent and human islets strongly suggest that glucotoxicity induced pancreatic beta cell damage …
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Retrograde Activation of a Somatic Transcriptional Program Regulates Distal Axon Degeneration
… of the developing nervous system, its improper activation may underlie several neurodegenerative disorders. This process can be modeled in vitro by culturing sensory neurons from mouse dorsal root ganglia in the presence of nerve growth factor either as explant cultures or in compartmented …
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Regulation of hnRNP A1 Cellular Localization by Protein Kinases and its Biological Impact
… decrease in HRV-infected cells and to decreased caspase activation in osmotically stressed and HRV-infected cells. Thus, HK2 may regulate hnRNP A1 cytoplasmic localization following HRV infection.
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The Role of Peroxiredixin Ⅲ in the ototoxic drug-induced mitochondrial apoptosis of cochlear hair cell
… potential collapse, cytochrome c relaease, and caspase activation. In conclusion, we demonstrated that cisplatin, gentamycin induced apoptosis was related to mitochondria-dependant pathyway through interaction with H2O2 and Prx III.
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Variability and Dynamics of Apoptotic Events in Single Cells
… cytochrome c and Smac from mitochondria, and the activation of the caspase family of proteases. The permeabilization of the mitochondria outer membrane is thought to represent the commitment of a cell to an apoptotic fate, and the subsequent release of mitochondrial proteins is an "all or none" …
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Neuroprotective effects of overexpression of the inhibitor of apoptosis proteins in the quinolinic acid model of excitotoxic injury.
… in neurons dying by apoptosis as assessed by caspase activation. Animals were intrastriatally injected with QA and striatal brain sections processed for several apoptotic markers. Recently, a novel family of inhibitor of apoptosis (IAP) proteins have been identified and subsequently shown to …
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ASSESSING AN M MUTANT VESICULAR STOMATITIS VIRUS FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME BY DETERMINING APOPTOTIC MECHANISMS AND ANTIVIRAL RESPONSE
… (dnFas) or over-expressing Bcl-XL had reduced caspase-3 activation following infection with M51R VSV indicating that both the death receptor and mitochondrial pathways are important for M51R VSV induced apoptosis. Direct activation of Fas in Bcl-XL over-expressing cells inhibited caspase …
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Cell Death Mechanisms in Drosophila Differentiated Photoreceptor Neurons
… complex, Ferritin. ferritin mutations lead to caspase activation and photoreceptor neuronal death during development and sensitize adult photoreceptor neurons to cell death stimuli. ferritin mutations provide a robust model to study the role of iron and oxidative stress in neurodegeneration. To …
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<i>In Vivo</i> Murine Melanoma Tumor Responses to Nanosecond Pulsed Electric Field Treatment
… vivo</em>, ranging from DNA fragmentation, caspase activation, nuclear damage, apoptosis induction, damage to pre-existing infra-tumoral vessels and neovascular inhibition. These tumor responses were expressed by histological and biochemical changes in both short and long term trials. The …
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Ehrlichia chaffeensis Activates Notch Signaling Through SLiM Mimicry to Inhibit Apoptosis
… of innate defenses of the macrophage involve activation of Wnt, Hedeghog and Notch signaling pathways. Interestingly, the E. chaffeensis tandem repeat effector, TRP120, has been shown to interact with host proteins important for activation and regulation of conserved signaling pathways …
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Novel Oligomeric Fluoropyrimidines and Their Efficacy for the Treatment of Colorectal Carcinoma Independent of p53 Mutation
… in vitro when assessing cell viability and caspase activation, 5-FU showed a dependency on normal p53 function in vitro while further studies are needed to conclude in vivo p53-dependency. The results also indicate that these fluoropyrimidines are viable treatments for CRC by showing tumor …
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Genetic analysis of programmed cell death in Drosophila melanogaster
… step in the execution of cell death is the activation of caspases, a conserved family of cysteine proteases. In Drosophila, the proteins, Reaper (Rpr), Head involution defective (Hid), and Grim, induce cell death via a mechanism that involves caspase activation. In order to further elucidate …
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