Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"caspase 9"”.
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The Regulation of the Alternative Splicing of Caspase 9
The pro-apoptotic, caspase 9a, and the anti-apoptotic, caspase 9b, are derived from the caspase 9 gene by alternative splicing. This study demonstrates that the alternative splicing of caspase 9 is dysregulated in a large percentage of non-small cell lung cancer (NSCLC) tumors of the adenocarcinoma …
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Identification of the RNA Cis-Elements that Interact with SRp30a to Regulate the Alternative Splicing of Caspase 9 Pre-mRNA
… have shown that the alternative splicing of caspase 9 and the phospho-status of SR proteins, a conserved family of splicing factors, are regulated by chemotherapy and de novo ceramide via the action of protein phosphatase-1 (PP1). Two RNA splice variants are derived from the caspase 9 gene, …
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The Intrinsic Caspase Death Pathway in Stroke Neurodegeneration
… disease onset. Cysteine-ASPartic proteASEs (caspases) are key mediators of apoptosis that are activated in distinct molecular pathways, but their impact in stroke is poorly defined. Direct evidence for caspase activation in stroke and the functional relevance of this activity has not been …
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iPLA2β, ALTERNATIVE SPLICING AND APOPTOSIS OF PANCREATIC ISLETS
… splicing of apoptosis-related genes, including caspase 9 and BCL-x. A recent study demonstrated that expression of neutral sphingomyelinase (NSMase), an enzyme that hydrolyzes sphingomyelins to generate ceramide, is regulated by Group VIA phospholipase A2 (iPLA2β)-dependent mechanism during …
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Biochemical Pathways in Apoptosis
Caspases are a family of proteases that once activated execute apoptosis, a cellular suicide pathway. Activated caspases have a unique property to cleave and activate themselves. Once the first caspase is activated, it generates a chain reaction resulting in robust caspase activity and rapid death. …
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Statin-associated skeletal muscle damage and its interactions with novel or accustomed exercise
… shock proteins (Hsps)—and apoptosis—activated caspases. Methods: C57 mice were treated with daily cerivastatin (1/mg/kg/day) or saline for two weeks, with/without concomitant wheel running (RW) (Novel & Sedentary groups). Additional groups also performed two weeks of RW activity prior to the …
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Characterization of the vaccinia virus M1 protein on caspase inhibition and the MVA/5.2KB virus on immunogenicity
… and characterization of the VACV M1 protein as a caspase inhibitor and (ii) investigating a previously unexplored method to alter the immunogenicity of the attenuated VACV MVA. One anti-viral host response inhibited by VACV during infection is apoptosis. The attenuated MVA strain of VACV, however, …
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Mechanismen der Inhibierung von Wirtszellapoptose durch <i>Toxoplasma gondii</i>
… die Fas/CD95-vermittelte Aktivität von Caspase 8, -9 und 3/7 sowie die Spaltung von Bid. Die Ligation von Fas/CD95 führte zu einer starken Aktivierung des intrinsischen Apoptosesignalweges, wie anhand der Cytochrom c-Freisetzung aus den Mitochondrien und einer deutlichen Aktivierung der …
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Antiproliferative activities of Euphorbia bicolor (euphorbiaceae) and Maclura pomifera (moraceae) extracts on estrogen receptor-positive and triple-negative breast cancer cell lines
… mechanisms. Key apoptotic markers such as caspase 3, caspase 8, caspase 9, FADD, FAS, ATF4, and CHOP were upregulated, while antiapoptotic BCL-2 expression was downregulated. Notably, the female extract also inhibited the PI3K/AKT pathway by reducing AKT and pAKT protein levels. Euphorbia …
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Biochemical and Molecular Characterisation of the FADDosome
… cell death pathway, which requires activation of caspase-9. However, our group has recently discovered that 5-FU-induced cell death is initiated by activation of caspase-8, whereas caspase-9 was found to be dispensable for this process. Moreover, our group has found that upon treatment with 5-FU, …
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Regulation of cytotoxic drug-induced apoptosis by death receptor 5 in human colon cancer cells
… the intrinsic apoptosis pathway which involves caspase-9 activation as one of the initiating molecular events. However, our group recently found the new apoptotic pathways which are involved in 5-FU-induced apoptosisin which caspase-8 is an essential factor for 5-FU-induced cell death with …
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Immunotoxic Effects of Mixtures of Endosulfan and Permethrin Via Caspase Dependent Thymocyte Apoptosis
… pesticides regulate apoptosis in immune cells. Caspases are a family of cystine-dependent, aspartate-directed proteases that have an integral role in apoptotic cell death. Caspases, which are normally inactive in healthy cells, are activated during apoptosis and form an irreversible cascade. …
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Anti – Cancer effects of Momordica charantia in- vitro
… to induce cell death measuring the activities of caspase - 3 and caspase - 9, the release of cytochrome c and intracellular free calcium concentrations [Ca 2+ ]i. The results have shown that the crude water soluble extract of M. charantia can evoke both time-course at (800 µg) and dose-dependent …
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Heat shock protein 27 inhibition of the caspase cascade in human breast cancer cells
… be released from the mitochondria initiating the caspase cascade. When there is an over-expression of Heat Shock Protein 27 (HSP27), the cell does not obey the death signals that it receives. In this study, the molecular mechanism for the HSP 27 inhibition of the caspase cascade is described in …
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Zellschdigungen und Mechanismen des Zelltodes in Oligodendrozyten nach oxidativem Stress
… Die Behandlung ergab ferner eine Aktivierung der Caspase-9 und Caspase-3. Oxidativer Stress führt weiter zu einer Aktivierung von ERK-1,2, einer Kinase die an der Regulierung des Zelltodes und Überlebens beteiligt ist. Die Daten zeigen, dass der mitochondriale Weg am durch oxidativen Stress …
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REGULATORY MECHANISM OF DUSP16 IN CANCER RESISTANCE TO PLATINUM-BASED THERAPIES
… Bax translocate to mitochondria to trigger caspase 9/3 apoptosis. We showed that inhibition or knocking out of Bax in DUSP16-overexpression cells abrogated DUSP16-mediated chemoresistance. In conclusion, this study demonstrated that DUSP16 expression in cancer cells inhibits p38/JNK-mediated …
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Cell Toxicology Study of RRR-Alpha-Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS).
… death. Induction of apoptosis, as measured by caspase 3 enzymatic activity, was dependent upon the TPGS dose and incubation time. Caspase 8 was activated before caspase 9, suggesting the importance of the death receptor pathway in apoptosis. Our results indicated that TPGS cytotoxicity could …
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Aktivierung von Caspasen in AKR-2B Mausfibroblasten
… Arbeit konnte die essentielle Beteiligung von Caspasen im Zelltodmodell der AKR 2B-Mausfibroblasten nachgewiesen und ihre Aktivitäten charakterisiert werden. AKR 2B-Mausfibroblasten stellen eine subklonierte und gut charakterisierte Zellinie dar, in der durch Entzug des Serums der Zelltod …
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Interactions of shiga-like toxin-2 (Stx-2) from Escherichia coli O157:H7 and the Bcl-2 family of proteins during host cell programmed cell death
… apoptosis and necrosis rates as well as on caspase-8 and caspase-9 activation. Stx-2 did not bind to the select Bcl-2 family proteins examined nor did it consistently show decreased apoptosis rates in neutrophils. The mechanisms behind Stx-2-induced neutrophil apoptosis potentially involved …
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