Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 601 for “"caspase"”.
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Entamoeba histolytica-Induced Caspase-4 Activation Regulates IL-1β Secretion Through Caspase-1
… EhCP-A5 ligates α5β1 integrin to activate caspase-1 in a complex known as the NLRP3 inflammasome. In this study, we investigated the parasite requirements underlying macrophage caspase-4 and -1 activation and the role caspase-4 play in augmenting pro-inflammatory cytokine responses. …
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Caspase isoforms in inflammasome activation
… NLRP3 or NLRC4), an adaptor (ASC) and effectors (caspases) that are thought to play critical roles in the host defence against microbial infections. Activation of inflammasomes leads to the processing of the pro-inflammatory cytokines pro-IL-1β and pro- IL-18 to their active form and cleavage of …
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Formation of caspase activating complexes and activation of caspase-12 during apoptosis in AKR-2B mouse fibroblasts
… Enzym hatte typische Eigenschaften von Effektor-Caspasen, wie die der Caspase-3, besaß jedoch einen ungewöhnlich hohen KM Wert von 100 µM, und die Molmasse der großen Untereinheit betrug 19 kDa anstelle der erwarteten 17 kDa. Mit Hilfe des rekombinanten mCaspase-3 Proteins wurde dieses Enzym in …
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Small Molecule Modulation of Caspase Enzymatic Activity
… the key mediators of the apoptotic signal are caspase enzymes. Caspases, a family of cysteine proteases, specifically cleave substrates C-terminal to an aspartic acid residue. Small molecule modulation of caspase activity can play an important role in the study of the apoptotic cascade, the …
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Single-cell reporters for inflammatory caspase activity
Caspases are a 12-member family of human proteases that regulate apoptosis and inflammation. They serve as key effectors downstream of diverse signaling receptors and shape cell fate. Inflammatory caspases mediate the proteolytic processing of inflammatory cytokines and are essential in maintaining …
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The Protumorigenic Role of Caspase-8 in Neuroblastoma
… of cancer-related deaths in pediatric patients. Caspase-8 (casp8), a proapoptotic protein, is silenced in approximately, 50-70% of neuroblastoma patient samples. Loss of casp8 has been suggested to increase NB metastasis and correlated, in some studies, with advanced-stage NB. Furthermore, …
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The Intrinsic Caspase Death Pathway in Stroke Neurodegeneration
… disease onset. Cysteine-ASPartic proteASEs (caspases) are key mediators of apoptosis that are activated in distinct molecular pathways, but their impact in stroke is poorly defined. Direct evidence for caspase activation in stroke and the functional relevance of this activity has not been …
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The Regulation of the Alternative Splicing of Caspase 9
The pro-apoptotic, caspase 9a, and the anti-apoptotic, caspase 9b, are derived from the caspase 9 gene by alternative splicing. This study demonstrates that the alternative splicing of caspase 9 is dysregulated in a large percentage of non-small cell lung cancer (NSCLC) tumors of the adenocarcinoma …
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The Role and Regulation of Caspase-2 in Lipoapoptosis
… death that promote this transition.</p><p>Since caspase-2 has been reported to respond to different types of intracellular metabolic stress to promote apoptosis, we investigated whether this enzyme promotes lipid-induced apoptosis, or lipoapoptosis, in tissue culture cells. We discovered that the …
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ROLE OF CKD AND CASPASE-1 IN NEOINTIMAL HYPERPLASIA DEVELOPMENT
… genes. Recent research indicates that Caspase-1 (casp-1) activation plays an essential role in sensing metabolic danger signal-associated molecular patterns and initiating vascular inflammation. Carbamylated LDL, a uremic toxin that has been shown to be found in higher levels in …
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Caspase-dependent Signaling as an Inductive Cue for Cardiac Hypertrophy
… we describe an essential role for apoptotic caspase-dependent signaling in the induction of pathological cardiac hypertrophy. Initially, we discovered that primary cardiomyocytes treated with hypertrophy agonists display transient activation of intrinsic-mediated apoptotic-signaling, …
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Induction of Caspase-Dependent Death By Proteasome Targeted Therapy In Glioblastoma
… I then determined that both BTZ and MRZ induced caspase-dependent death in GBM cells that was dependent upon activation of caspase 9. Using an orthotopic xenograft model of GBM, I found that both BTZ and MRZ increased levels of the proteasome substrates p21 and p27 in intracranial tumors, with …
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TRAF Regulation of Caspase-2-Dependent Apoptosis in Response to DNA Damage
… of the spindle checkpoint.</p><p> The protease caspase-2 has previously been shown to be an important regulator of DNA damage-induced apoptosis. In unstressed cells caspase-2 is present as an inactive monomer, but upon sensing a stress caspase-2 dimerizes and becomes catalytically active. The …
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Is It Memory or Is It Death? Caspase-3 and Memory Formation
"Caspase-3 is a protease associated with development, cancer defense, and various disease states including Stroke, Alzheimer's and Parkinson's. Activation of caspase-3 is normally thought of as the terminal step in the biochemical cascade of apoptosis (programmed cell death). However, it is present …
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Development of a synthetic route to aminofluorohexenones as precursors for novel caspase inhibitors
… In cancer cells, a family of proteases called caspases, is involved in one or more of the signaling pathways leading to apoptosis. To better understand this cellular mechanism at the molecular level, selective inhibition of each caspase would allow scientists to determine the exact function of …
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STRUCTURAL AND FUNCTIONAL DETERMINANTS OF CASPASE-11 INFLAMMASOME ASSEMBLY DURING INNATE IMMUNE DEFENSE
Caspase-11 (Casp11) is a pattern-recognition receptor that senses cytosolic LPS. In response to binding cytosolic LPS, Casp11 assembles into a supramolecular organizing center (SMOC) designated the noncanonical inflammasome, where it is thought to undergo proximity-induced autoprocessing and become …
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Immunotoxic Effects of Mixtures of Endosulfan and Permethrin Via Caspase Dependent Thymocyte Apoptosis
… pesticides regulate apoptosis in immune cells. Caspases are a family of cystine-dependent, aspartate-directed proteases that have an integral role in apoptotic cell death. Caspases, which are normally inactive in healthy cells, are activated during apoptosis and form an irreversible cascade. …
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Heat shock protein 27 inhibition of the caspase cascade in human breast cancer cells
… be released from the mitochondria initiating the caspase cascade. When there is an over-expression of Heat Shock Protein 27 (HSP27), the cell does not obey the death signals that it receives. In this study, the molecular mechanism for the HSP 27 inhibition of the caspase cascade is described in …
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Characterization of three Drosophila melanogaster regulators of programmed cell death that lead to caspase activation
… deaths during development, can help activate caspases in vitro, and appears to aid in the activation of procaspases overexpressed in the Drosophila eye. Interestingly, like reaper, hac-1 transcription is rapidly upregulated in response to UV and X-irradiation. An essential regulator of …
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Resistenz gegenüber TRAIL-vermittelter Apoptose beim Ewing-Sarkom durch Caspase-8 Mangel - Modulation durch IFN-gamma-
… eine verminderte Expression von Caspase-8 gefunden. Diese war auch auf Proteinebene im Western Blot nachvollziehbar. Mittels IFN-gamma Behandlung ließen sich die beiden resistenten Zelllinien A4573 un JR gegenüber TRAIL-vermittelter Apoptose sensibilisieren. Als Ursache für dieses …
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