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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"casein kinase 2"”.
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Casein-Kinase-2-Beta und neuronale Entwicklungsprozesse
… als eine durch Transposon- Insertion in den Casein-Kinase-2ß-Genlokus verursachte, hypomorphe Mutation identifiziert, die zu einer starken Verringerung der Anzahl der die Pilzkörper bildenden intrinsischen Neurone führt. Eine Reversion des mbuP1-Pilzkörperphänotyps konnte unter anderem durch …
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Development of novel lysine targeting covalent inhibitors for Bruton’s tyrosine kinase and casein kinase 2 and synthesis of novel hybrid androgen receptor inhibitors
Cancer is the lead cause of death worldwide, accounting for 10 million deaths in 2020, or 1 in 6 deaths. While current therapies have significantly advanced in the last decade, they suffer from severe limitations such as resistance, lack of selectivity and life-threatening side effects. Herein we …
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Identifikation des Transportproteins PACS-1 als Nephrocystin-interagierendes Protein
… im Acidic Cluster. Phosphorylierung durch Casein Kinase 2 vermittelt und Dephosphorylierung hemmt die Interaktion mit PACS-1. Unsere Befunde legen nahe, dass PACS-1 an der Rekrutierung des Nephrocystin-Proteinkomplexes in das Trans-Golgi-Network, die Sortierstation der Zelle, beteiligt ist. …
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Development of Rational Combination Therapy With Parp Inhibitors and Kinase Inhibitors In Tnbc
… In this study, we identified c-Met, a tyrosine kinase, phosphorylates PARP1 at Y907 and that the phosphorylation increases PARP1 activity, thereby rendering cancer cells resistant to PARPi. The combination of c-Met inhibitors (METi) and PARPi has a synergistic effect for c-Met overexpressed TNBC …
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Understanding The Repair Mechanisms at Ionizing Radiation-induced Damage in The Human Genome
… was dependent on XRCC1 phosphorylation by casein kinase 2 (CK2) that enhanced the interaction of XRCC1 with the end resection enzymes Mre11 and CtIP. The XRCC1 immunocomplex isolated from U2OS cells had Alt-EJ activity in vitro; this activity was significantly higher in the immunocomplex …
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The Role of Post-Translation Regulation of Twist Expression In The Tumor Progression of Squamous Cell Carcinoma of Head and Neck
… TWIST has a putative phosphorylation site for casein kinase 2 (CK2) suggesting that this kinase could serve as a link between IL-6 stimulation and Twist stability. To test this hypothesis, we used a CK2 inhibitor and shRNA to CK2 and found that these interventions inhibited IL-6 stimulation of …
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The Mechanism of Assembly of the G-Protein Beta Gamma Subunit Dimer by CK2 Phosphorylated Phosducin-Like Protein and the Chaperonin Containing TCP-1
… of PhLP at serine residues 18-20 by the casein kinase 2 (CK2) appears to play an essential role in this process. PhLP has also been shown to interact with the chaperonin containing TCP-1 (CCT) atop its apical domain, not entering the substrate folding cavity. However, the physiological …
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Multiple Functions of BRD4 in E2 Mediated HPV Transciptional Regulation
… interacts only with high risk E2 (HRE2) in a casein kinase 2 (CK2) phosphorylation-dependent manner. In addition to HRE2-specific interaction, the phosphorylation of PDID also induces intramolecular interaction between PDID and E2ID, which blocks the E2-interaction of E2ID. Finally, we show …
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Funktionelle Charakterisierung der CK2-vermittelten Phosphorylierung des Transkriptionsfaktors TIF-IA bei der Regulation der Synthese ribosomaler RNA
… funktionell aufzuklären und die entsprechende Kinase zu identifizieren. Durch Herstellung einer nicht-phosphorylierbaren Mutante (TIF-IAS170A/S172A) konnte gezeigt werden, daß die Serine 170 und 172 durch Casein-Kinase 2 (CK2) in vitro und in vivo phosphoryliert werden. Die Analyse der …
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Alternative splicing and RNA editing of the Complexin C-terminus regulates neurotransmitter release in Drosophila
… to tether to synaptic vesicles. Additionally, casein kinase 2 was found to phosphorylate the N130S variant. Together, these findings indicate Cpx7A and Cpx7B have redundant roles in controlling baseline neurotransmission, while differential RNA editing of Cpx7A alters Cpx’s clamping properties …
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The Role of Nucleolin Phosphorylation by CK2 in Regulating Cellular Fate Under Normal and Stress Conditions
… the role of nucleolin phosphorylation by casein kinase 2 (CK2) in controlling cellular fate by regulating p53 checkpoint under normal and stressed conditions. First, I demonstrate that the six consensus CK2 sites on the N-terminus of NCL are important for cell survival and proliferation. …
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Characterization of insulin-stimulated protein kinase cascade in normal and diabetic rats and the effects of vanadium
Multiple protein kinases acting in a sequential manner have been identified to constitute a kinase cascade that mediates growth factor or mitogen-activated signal transduction. The cascade is triggered at the cell membrane by the activation of receptor tyrosine kinases, which pass on the signal in …
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Unravelling the roles of the Mck1 kinase in metabolic reprogramming and the stress response
… Previous work in the lab revealed that the Mck1 kinase, one of the four GSK3 homologues in Saccharomyces cerevisiae, is a key regulator of stationary phase entry. Further study indicated that Mck1 promotes UDPG synthesis during the transition to the stationary phase to enable cell wall thickening …
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Investigation of the roles of a membrane-bound caleosin in higher plants
… can be phosphorylated most likely, by a casein kinase 2 (CK2) protein kinase, and has putative peroxygenase activity. In addition to biochemical data, microscopy analysis shows that Clo-3 may be located both on the endoplasmic reticulum and chloroplastid<br/>envelope membranes. …
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Interactions between Folate Deficiency and β-Nicotinamide Adenine Dinucleotide Deficiency and Conformational Study of Thymidylate Synthase and its Physiological Relevance
… residue that is phosphorylated by the protein kinase, casein kinase 2 (CK2). Phosphorylation of the enzymes by CK2 was analyzed by isoelectrofocusing. A191K showed multiple phosphorylation sites while hTS and R163K only showed one site, indicating that phosphorylation by CK2 is …