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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"cascade impactor"”.
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Developing a method to sample potential resuspension of radioactive contaminants near the former Rocky Flats Technical Plant
… regard to particle size fraction, the use of a cascade impactor to separate aerosols by size can be utilized to relate how deep varied-sized particles might penetrate the human respiratory tract after inhalation. This would not only indicate the presence of radionuclides but also the deposition …
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Characterization and Concentration of Particulate Matters Emitted From Confinement Animal Buildings
… particles were performed using a six-stage cascade impactor from nine different animal farms (swine finishing, farrowing, and layer hen housing). The measured bioaerosol concentrations varied from 12,000 to 28,000 CFU/m3 showing seasonal variation from each animal facility. The seasonal …
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Preliminary Assessment: Identification of Chinese Drywall and Exposure to Particulate Matter and Metals during Cutting and Installation of Drywall
… cutting and installation of drywall using 8stage Cascade impactor. The work space concentration of, different metals is analyzed using XRF analysis and particulate matter within various size ranges, were calculated and their effects are studied.
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Performance of two different types of inhalers. Influence of flow and spacer on emitted dose and aerodynamic characterisation.
… of the emitted dose were measured by an Anderson cascade impactor (ACI) and the next generation cascade impactor (NGI). In all aerodynamic characterisations, the differences between flow rates 28.3 and 60 were statistically significant in formoterol, budesonide R and budesonide S, while the …
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Chemistry of airborne particles from metallurgical processing
… aerosol. This analysis was performed with a cascade impactor and energy dispersive spectrometry with both scanning electron microscopy (SEM-EDS) and scanning transmission electron microscopy (STEM-EDS). Other methods for properly characterizing particles were discussed. In the analysis, less …
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Numerical Analysis of Respiratory Aerosol Deposition: Effects of Exhalation, Airway Constriction and Electrostatic Charge
… an aerosol size sampler, an eight-stage Andersen cascade impactor (ACI) was numerically analyzed. The numerical simulations indicated high non-uniformity and recirculation in the flow field. Numerical predictions of retention fraction matched well with existing experiments (0.5 – 11% error). …
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Formulation studies on cysteamine for the treatment of nephropathic cystinosis.
… lung delivery (1-5 micro-m). However, Andersen Cascade Impactor analysis revealed poor deep-lung penetration. In conclusion, these results demonstrated that more development work was required to produce a useful pulmonary formulation of cysteamine; however, formulation of an ocular applicable …
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Development and Evaluation of a Small Volume Liquid Impaction Surface (SVLIS) in the Next Generation Impactor (NGI)
… Impaction Surface (SVLIS) in the Next Generation Impactor (NGI), a cascade impactor for evaluation of aerodynamic particle size distribution. This SVLIS modified NGI allowed for incorporation of lung cell cultures or drug dissolution of orally inhaled powders following aerosolization.|A custom …
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INFLUENCE OF ELECTROSTATIC CHARGE UPON THE DEPOSITION BEHAVIOR OF PHARMACEUTICAL AEROSOLS WITHIN CASCADE IMPACTORS
Cascade impactors, routinely used for in vitro particle size characterization of pharmaceutical aerosols, are calibrated using dilute, charge-neutralized, monodisperse aerosols. But pharmaceutical aerosols are known to generate concentrated, inherently charged, polydisperse aerosol clouds. A …
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Discovery and Characterization of Small Molecule Inhibitors of Biofilm Formation in Pseudomonas Aeruginosa
… distributive properties in an Andersen cascade impactor model of lung-targeted drug delivery, highlighting the potential of these chelators as nebulized agents to combat P. aeruginosa in Cystic Fibrosis. Previous research showed that production of excess rhamnolipids in P. aeruginosa …
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Pharmaceutical analysis and in-vitro aerodynamic characterisation of inhaled theophylline formulations containing drug particles prepared by supercritical fluid processing. Chromatographic, spectroscopic, and thermal analysis of micron-sized theophylline particles prepared by supercritical fluid technology and in-vitro evaluation of their performance as inhaled dry powder formulations.
… tested. The dose sampling unit and the Anderson Cascade Impactor were used to determine the in-vitro emitted dose and the deposition profiles of SEDS samples, respectively. The effect of different inhalation flows was studied using two different flows 28.3, and 60 L min-1 with 4 L inhalation …
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Optical Sensors for High-Temperature Pressure Measurement and Real-Time Particle Detection
… this work, we incorporate a fiber taper into a cascade impactor and show that welding aerosols attached to the fiber taper surface can induce measurable transmission loss during the welding process.
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SET-UP OF INNOVATIVE EXPERIMENTAL METODOLOGIES FOR THE ATMOSPHERIC AEROSOL CHARACTERISATION AND SOURCE APPORTIONMENT
… size distribution without using multistage impactors. As previously mentioned, the ED-XRF analysis on cascade impactor samples analysis set-up in this work allowed the validation of this new methodology for size-segregated distribution estimation; 3) design, set-up and test of a sample …
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A novel cough aerosol sampling device for sputum-scarce individuals with tuberculosis
… was designed in subsystems, namely the impaction cascade, pump system, mask part and casing. All subsystems followed a rapid prototyping approach characterised by multiple design iterations. The impaction cascade design was guided by Marple and Liu's methodology (1976). This included testing …
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Relative Bio-Equivalence of Salbutamol MDIs Without and With the Attached Spacers. Development and validation of novel HPLC methods for the determination of salbutamol (and terbutaline) in urine excreted post-inhalation for bioequivalence and pharmacokinetic studies of Salbutamol MDIs
… quality attributes of the MDI using an Andersen cascade impactor (ACI) were examined and included measurement of fine particle dose (FPD) and total delivered dose (TDD). Bioequivalence studies were conducted in humans using the urinary pharmacokinetic method. Post-inhalation urinary excretion of …
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Relative bioavailability of terbutaline to the lungs following inhalation using different methods.
… size distribution was measured using an Anderson Cascade Impactor (ACI) with a mixing inlet valve to allow measurement at different flows. A steady increase in total emitted dose (TED) and the fine particle dose (FPD) was observed as the inhalation flow increased thereby highlighting the flow …
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A STUDY ON PARTICLE SURFACE ROUGHNESS AND ITS IMPACT ON TABLET AND INHALER TECHNOLOGY
Powder flow is an integral component in pharmaceutical manufacturing. Various powder flow methodologies were examined and correlated with each other using lactose of various shape and size. In-die powder flow during tableting was studied using lactose particles of different surface roughness. …