Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 71 for “"cartilage tissue"”.
-
Photoactivated Fixation of Cartilage Tissue
Cartilage repair and/or replacement is necessary for many orthopaedic conditions including fissures from blunt trauma, autograft or allograft transplantation, and replacement of focal defects with biological or synthetic constructs. In cartilage repair, initial integration between the host tissue …
-
Chitosan fibrous scaffolds for cartilage tissue engineering
… with glycosaminoglycans make it attractive for cartilage engineering despite its limited cell adhesion properties. Structural and chemical characteristics of chitosan scaffolds may be improved for cartilage engineering application. We planned to evaluate chitosan meshes produced by a novel …
-
Novel Biomaterials for Applications in Cartilage Tissue Engineering
… joint condition involving the deterioration of cartilage and subchondral bone, which impacts millions of individuals globally. Its high prevalence is attributed to the ineffective intrinsic healing of cartilage due to its avascular nature. Consequently, the limited healing capacity of cartilage, …
-
Optimizing a scaffoldless approach for cartilage tissue engineering
Articular cartilage has a poor intrinsic healing response, so tissue engineering provides a promising approach for cartilage regeneration. The major objective of this proposal was to enhance the self-assembling process, used in articular cartilage tissue engineering, by investigating the effects of …
-
Injectable hyaluronic acid scaffolds for cartilage tissue engineering
Every year tens of millions worldwide suffer from cartilage damage, caused by mechanical degradation, trauma or disease. Because of the lack of blood supply and low cell concentration within the tissue, cartilage has very limited regenerative ability. Although current treatments can provide …
-
Enhancing Mesenchymal Stem Cell Chondrogenesis for Cartilage Tissue Engineering
Articular cartilage provides a bearing surface for transmitting forces across joints. The poor ability of cartilage to self-repair has motivated efforts to engineer replacement tissues, and mesenchymal stem cells (MSCs), which can undergo chondrogenesis, have emerged as a promising cell source. To …
-
Engineering Dynamic Granular Composites for the Repair of Cartilage Tissue
… used as ‘building blocks’ to generate engineered tissues. MSC spheroids can fuse together to produce high cell density, macroscopic tissues with enhanced functional properties; however, their potential is hindered by challenges in the stabilization of and control over fusion. Hydrogel …
-
Decellularized cartilage as a chondroinductive material for cartilage tissue engineering
Cartilage defects, whether caused by osteoarthritis, joint trauma, or other disease, have provoked a wide variety of tissue engineering scaffold strategies in recent years. Traditionally, cartilage tissue engineering scaffolds have utilized synthetic polymer components to form hydrogels or other …
-
Deformation and fracture of soft materials for cartilage tissue engineering
Damaged cartilage can cause severe pain and restricted mobility, with few long term treatments available. The developing field of tissue engineering offers an alternative to the currently used full joint replacement. Restoring damaged cartilage through tissue engineering would enable an active …
-
Developing osteoarthritis treatments through cartilage tissue engineering and molecular imaging
Tissue engineering can be applied to develop therapeutic techniques for osteoarthritis, a degenerative disease caused by the progressive deterioration of cartilage in joints. An inherent goal in developing cartilage-replacement treatments is ensuring that tissue-engineered constructs possess the …
-
Cell-seeded type II collagen scaffolds for articular cartilage tissue engineering
Defects in articular cartilage exhibit little spontaneous healing response, in part due to the limited number of chondrocytes available to infiltrate the defect and the absence of a provisional fibrin scaffold to accommodate cell migration into the lesion. One variable related to tissue engineering …
-
Design of an Electrospun Type II Collagen Scaffold for Articular Cartilage Tissue Engineering
Traumatic defects in articular cartilage can lead to joint disease and disability including osteoarthritis. Because cartilage is unable to regenerate when injured, the field of tissue engineering holds promise in restoring functional tissue. In this research, type II collagen was electrospun, …
-
Chondrocyte metabolism and matrix nano-electromechanics : the response to cartilage tissue shear deformation
Cartilage functions as a load bearing and friction reducing material in synovial joints and it is constantly exposed to in vivo loading which is coupled to electromechanical and physicochemical forces. The swelling pressure of cartilage originates from proteoglycans containing negatively charged …
-
Electrospun Scaffolds for Cartilage Tissue Engineering: Methods to Affect Anisotropy, Material and Cellular Infiltration
… producing electrospun scaffolds for use in the tissue engineering of articular cartilage. We developed a novel method of imparting mechanical anisotropy to electrospun scaffolds that allowed the production of a single, cohesive scaffold with varying directions of anisotropy in different layers …
-
Gene-supplemented collagen-glycosaminoglycan scaffolds for nonviral gene delivery in articular cartilage tissue engineering
… have been shown to be important for articular cartilage tissue engineering. A major problem in using recombinant proteins in vivo, however, is the inability to maintain therapeutic levels over prolonged times due to degradation or diffusion from the defect site. The goal of this thesis was to …
-
Preconditioning Methods in Cartilage Tissue Engineering: Influences of Silk Material Properties and Hypoxia on Chondrogenesis
Cartilage has limited intrinsic healing potential, due to the low cell density and the lack of blood supply. Current treatments for cartilage repair rarely restore full structure and function to the native state. Tissue engineering holds promise to create cartilage grafts capable to withstand the …
-
The Influence of Manufacturing Method and Collagen on the Mechanical Performance of Sodium Alginate-Based Scaffolds for Cartilage Tissue Engineering
Cartilage has limited ability to repair itself making it a good candidate for artificial tissue replacements. Hydrogels such as sodium alginate (SA) have been used in bioprinting and tissue engineering for their favourable properties, however, the mechanical performance of engineered tissue …
-
The effect of synthetic cannabinoids on wound healing of chondrocytes monolayers and pseudo 3D cartilage tissue. Effect of different concentrations of synthetic cannabinoids WIN55, 212-2, URB602 and HU-308 with and without their antagonists on wound healing of chondrocyte monolayers and pseudo 3D cartilage tissue.
… of cannabinoids and also their potentials for cartilage repair and regeneration. Various wound healing techniques can be used to investigate the mechanisms of chondrocyte repair in monolayers or three dimensional tissue constructs. The effect of different concentrations of the synthetic …
-
Engineering Collagen Nanostructure to Enable Stiff & Tough Cartilage Biomaterials
… the body, and the main structural component of cartilage tissue. As such, collagen has been widely investigated as a biomaterial for tissue engineering. However, the process of extracting collagen and processing it to form functional materials has failed to recapitulate the mechanical and …
-
Chondrogenesis of Stem/Progenitor Cells by Chemotaxis Using Novel Cell Homing Systems
The predominant approach for cartilage tissue engineering involves cell transplantation with or without cytokine delivery, biomaterial scaffolds, bioreactors, applied mechanical stimulation and altered oxygen tension. Despite its scientific merit, cell delivery faces drawbacks including scarce cell …
Page 1 of 4