Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"cartilage matrix"”.
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Compositional studies of cartilage matrix using NMR spectroscopy
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1993.
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Articular cartilage--matrix assembly, mediation of chondrocyte metabolism, and response to compression
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1996.
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Aggrecan fragments as biomarkers in osteoarthritis
Background: In osteoarthritis (OA) the balance of cartilage matrix synthesis and degradation is disturbed, resulting in a gradual destruction of the articular cartilage. Matrix components released into body fluids by proteolytic cleavage can be used as biomarkers of ongoing processes. This thesis …
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Finite Element Analysis of an In Vitro Traumatic Joint Loading Model
… characterized by the degeneration of articular cartilage resulting in eventual bone on bone contact causing pain and inflammation to musculoskeletal joints. An in vitro impact injury model that incorporated tangential loading was developed in our lab using intact porcine patellae to produce …
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Mechanical injury and inflammatory cytokines affect cartilage integrity and tissue homeostasis : a mass spectrometric analysis of proteins with relevance to arthritis
… is degeneration and loss of the articular cartilage joint surface. While the aetiology of osteoarthritis is unknown, risk factors include gender, age, obesity, and prior joint injury. Joint injuries, including tears of the anterior cruciate ligament (ACL) and meniscus, increase the risk for …
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Anterior Cruciate Ligament injury, Patient Variables, Outcomes and Knee Osteoarthritis
… examined with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) to estimate cartilage GAG content, as a proxy for cartilage integrity. Results indicated knee cartilage GAG changes 2 years after an ACL injury. Patients who had sustained a meniscectomy, or had a BMI > 25 kg/m2, had the most …
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Development of a Human Tibiofemoral Joint Finite Element Model to Investigate the Effects of Obesity and Knee Malalignment on Joint Contact Pressure
… malaligned knee would have an additive effect on cartilage stress and could cause stress levels to exceed the threshold limit for damage and loss of cartilage matrix.</p> <p>A finite element (FE) model of the human tibiofemoral joint was developed and validated in order to investigate changes in …
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FRACTURE HEALING IN A RABBIT MODEL: A STUDY OF OSTEOCALCIN LOCALISATION
… bone stained strongly for osteocalcin; bone matrix stained lightly for the protein. The optimum method for osteocalcin localisation in human bone was adapted using a newly developed rat anti-rabbit osteocalcin antibody, for use on immature 5-day old rabbit bone, used as a source of active …
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Cartilage response to in vitro models of injury in combination with growth factor and antioxidant treatments
… mechanical compression, cytokine treatment, and cartilage co-cultured with adjacent tissue, in vitro models can give insight into key biological and mechanical pathways occurring in vivo. This study focuses on changes in cartilage gene and protein expression and associated cartilage matrix …
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EFFECTS OF OSTEOARTHRITIS AND INFLAMMATION ON MENISCUS CELL RESPONSE TO OSTEOGENIC PROTEIN 1 (OP1)
… the upregulation of catabolism (extracellular matrix breakdown) which outpaces anabolism (matrix synthesis). OP1 has been shown to be the most potent natural inducer of articular cartilage matrix synthesis. We chose to evaluate this growth factor for its ability to induce meniscus matrix …
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Osteochondral allograft preservation in a serum-free chemically-defined media
Articular cartilage has a very limited capacity as compared to other biological tissues to repair and regenerate because of its avascular nature. Chronic degradation of articular cartilage may result in osteoarthritis, the most common debilitating disease worldwide. In order to alleviate severe …
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Diffusional Properties of Articular Cartilage
Articular cartilage is the connective tissue that lines joints and provides a smooth surface for articulation and shock absorption. Osteoarthritis, the progressive degeneration of cartilage, is a painful, debilitating, and widespread disease, affecting 70% of people over 65. Because cartilage is …
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Optimizing chondrogenic factors and protein delivery methods for cartilage repair
… are common and often result in damage to cartilage, which has a limited ability to repair itself. Tissue engineering is a promising approach for improving cartilage healing in which biomaterials and chemical factors are supplied to direct cells to create a new tissue. The objective of this …
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Investigation into the immuno-therapeutic potential of melanocortin peptides on activated chondrocytes
… articular chondrocytes significantly up-regulate matrix metalloproteinases (MMPs) gene expression, and inhibit the chondrocyte’s compensatory synthesis pathways required to restore the integrity of the degraded extracellular matrix (ECM). Human C-20/A4 and primary bovine articular chondrocytes …
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Bone Marrow-Derived Buffy Coat Can Supplement the Bone Marrow Stimulation Technique for Articular Cartilage Repair
… Bone Marrow Stimulation Technique for Articular Cartilage Repair Bone marrow stimulation (BMS) has been used as a popular operating technique to repair defect of knee articular cartilage. However, the regenerated tissue from BMS is known as a fibrocartilage rather than a hyaline cartilage and …
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The Role of Tumor Necrosis Factor-Stimulated Gene 6 Protein (TSG-6) in Osteoarthritis
… we could reliably separate and isolate articular cartilage and site-matched subchondral bone with high fidelity. We also set up a model system based on specific regions of interest within a joint corresponding to a gradient of disease severities; this system can be used to represent early …
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The Mechanism of Action of Hyaluronan Therapy as a Treatment for Osteoarthritis and the Assessment of Osteoarthritic Articular Cartilage Using Ultrasound
… hyaluronan (HA) therapy interacts with articular cartilage at the molecular and tissue level, and (2) whether quantitative ultrasound imaging can detect early degenerative changes in articular cartilage before irreversible osteoarthritic damage develops. By combining molecular characterisation, ex …
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Molecular pathway analysis and therapeutics development in post-traumatic osteoarthritis
… (PTOA) refers to the progressive degradation of cartilage often triggered by a traumatic joint injury, such as a tear of the meniscus or anterior cruciate ligament (ACL). Such impact injuries lead to elevated levels of inflammatory cytokines in the synovial fluid of the joint, including IL-1, …
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Relevanz der humanen Xylosyltransferase-I in der Seneszenz-assoziierten Gewebe-Remodellierung und der adulten Knochenhomöostase
… are significantly involved in extracellular matrix (ECM) remodeling by catalyzing the initial step of proteoglycan (PG) biosynthesis. Aberrant XT-I gene expression and activity is associated with age-associated diseases such as fibrosis or osteoarthritis, but also with the occurrence of …
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The role of mechanical loading in chondrocyte signaling pathways
… are a predominant cell type present in articular cartilage, whose integrity is jeopardized in joint degenerative diseases such as osteoarthritis (OA). In the chondrocytes of patients with OA, the elevated levels of inflammatory cytokines such as interleukin 1β (IL1β) and tumor necrosis factor α …
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