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Showing 1 to 13 of 13 for “"cartilage defect"”.
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The healing of an autogenous osteochondral graft and a full thickness cartilage defect in the canine talus: compared by functional, radiographic and histological assessment
A circular (5.5mm diameter) full thickness cartilage defect was created on the medial ridge of the talus in twelve skeletally mature dogs. In six dogs the articular surface of the lesion was repaired using an osteochondral graft obtained from the ipsilateral manus. The graft (Digit I, 1st phalanx, …
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Bone Marrow-Derived Buffy Coat Can Supplement the Bone Marrow Stimulation Technique for Articular Cartilage Repair
… Bone Marrow Stimulation Technique for Articular Cartilage Repair Bone marrow stimulation (BMS) has been used as a popular operating technique to repair defect of knee articular cartilage. However, the regenerated tissue from BMS is known as a fibrocartilage rather than a hyaline cartilage and …
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Use Of synthetic solid scaffolds to mechanically support a chondrocyte-seeded peptide hydrogel for articular cartilage repair
… (PTOA) is a subtype of OA associated with cartilage defects caused by traumatic joint injury. Because articular cartilage has a limited innate healing response, due to its avascular, aneural, and alymphatic nature, these defects lead to chronic degenerative joint disease if left untreated. …
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Chondrogenesis of Stem/Progenitor Cells by Chemotaxis Using Novel Cell Homing Systems
The predominant approach for cartilage tissue engineering involves cell transplantation with or without cytokine delivery, biomaterial scaffolds, bioreactors, applied mechanical stimulation and altered oxygen tension. Despite its scientific merit, cell delivery faces drawbacks including scarce cell …
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Development and Characterization of Photocrosslinkable Hyaluronic Acid Hydrogels for Cartilage Regeneration
Damage to cartilage from general wear, disease, or injury can lead to joint pain and tissue degeneration. With its limited ability for self-repair, cartilage has become a target for tissue engineering (TE). As current treatments have yet to provide long-term functional cartilage repair, this …
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The Roles of the Normal Mechanical Properties of Articular Cartilage in the Contact Mechanics of the Human Knee Joint: a Finite Element Approach
… to the study of the mechanical behaviour of cartilage, few of them considered fluid pressure in an anatomically accurate knee joint model. Including the fluid phase as a cartilage constituent, this thesis investigated the mechanics of human knee joint. The main hypothesis of this thesis was …
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Application of endostatin using nonviral gene delivery toward the regeneration of articular cartilage
Articular cartilage is avascular, and defects have limited capacity for spontaneous healing. Angiogenesis may interfere with maturation of naturally avascular tissues. Our rationale is that the use of endostatin, a potent angiogenesis inhibitor, will facilitate the formation of hyaline cartilage …
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In vitro and in vivo growth factor delivery to chondrocytes and bone-marrow-derived stromal cells in cartilage and in self-assembling peptide scaffolds
The inability of articular cartilage to repair itself after acute injury has been implicated in the development of osteoarthritis. The objective of this work was to develop methods for delivering growth factors to cartilage and to test the ability of a self-assembling peptide scaffold, (KLDL)3, …
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SPECTROSCOPIC ASSESSMENT OF TISSUE ENGINEERED CARTILAGE: A PATHWAY FOR BENCH TO BEDSIDE EVALUATION OF CARTILAGE DEVELOPMENT AND REPAIR
Cartilage tissue engineering is a promising approach for the repair of chondral defects. Engineering of cartilage combines a three-dimensional scaffold with chondrogenic cells and appropriate external stimuli, and ideally results in constructs with properties that resemble, as closely as possible, …
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The Effects of Low Intensity Ultrasound on Chondrogenic Differentiation of Rabbit Mesenchymal Stem Cells In Vivo
… The constructs were then implanted into the cartilage defects that were created in rabbit femoral trochlea. In the Study II and III, the chondrocytes-seeded PGA constructs served as a positive control. Analyses of gross examination, histology, biochemical assays, mechanical test and RT-PCR …
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Single-dose growth factor treatments to enhance cell recruitment and neotissue integration in an augmented microfracture cartilage repair model
Focal cartilage defects caused by joint injury have a limited capacity to self-repair, and if left untreated, can lead to the early onset of osteoarthritis. The current gold standard of care, microfracture surgery, induces an endogenous repair response, but typically results in poorly integrated …
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Klinische und kernspintomographische Ergebnisse nach Implantation von artifiziellen TruFit-Zylindern in die Entnahmedefekte bei der autologen Knorpel-Knochen-Transplantation
Ziel der Arbeit: In der Literatur wird die Entnahmemorbidität nach Knorpel-Knochen-Transplantation (OCT) mit bis zu 50% angegeben (Valderrabano et al. 2009). In der vorliegenden Studie wurde geprüft, ob die Implantation von TruFit-Zylindern der Firma Smith & Nephew in die Entnahmedefekte einen …
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Lebensqualität und Gelenkfunktion nach Knorpel-Knochen-Transplantation
Ziel war die Ermittlung des klinischen Therapieeffektes der Knorpel-Knochen Transplantation. Mit der Hypothese, dass durchschnittlich 7 Jahre postoperativ eine signifikante Verbesserung von (1) Lebensqualität, (2) Gelenkfunktion und (3) Knorpelstruktur vorliegt (p<0,05), wurde der Einfluss von …