Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"carotid ligation"”.
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Vascular Injury In Col3A1+/- Mice Model of Vascular Ehler-Danlos Syndrome
… potential therapies for vEDS patients.</p> <p>Carotid ligation was applied to the <em>Col3a1<sup>+/-</sup> </em>mouse as an injury model, and the results confirm that <em>Col3a1<sup>+/-</sup> </em>mice have aberrant arterial injury repair. Arteries from the injured <em>Col3a1<sup>+/-</sup> …
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Prenatal Undernutrition, Metyrapone, and the Cerebrovasculature
… then underwent Hypoxia-Ischemia (±) (unilateral carotid ligation combined with 1.5 hours 8% hypoxia after 24 hours). The goal of both studies was to determine whether glucocorticoids would increase ischemic vulnerability, an important marker of vascular health. Our results demonstrated that food …
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FOXO3a in Vascular Smooth Muscle Cell Apoptosis
… to enhanced neointimal formation during carotid ligation. Finally, endogenous FOXO3a activation leads to increased MMP-13 expression in human VSMCs, but not mouse. Overall, we have shown that FOXO3a promotes VSMC apoptosis through MMP-13 both in vitro and in vivo, a novel pathway that has …
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The Role of the Pituitary-Adrenal Axis in G-CSF Therapy after Neonatal Hypoxia-Ischemia
… old rats (P7) were subjected to unilateral carotid ligation followed by 2.5 hours of hypoxia. Our results show that both G-CSF and metyrapone significantly reduced infarct volume via anti-apoptotic properties but lost its protective effect when combined with dexamethasone. Additionally, …
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Role of the Pituitary-Adrenal Axis in G-CSF Therapy after Neonatal Hypoxia-Ischemia
… old rats (P7) were subjected to unilateral carotid ligation followed by 2.5 hours of hypoxia. Our results show that both G-CSF and metyrapone significantly reduced infarct volume via anti-apoptotic properties but lost its protective effect when combined with dexamethasone. Additionally, …
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Delayed Thrombus Resolution and Fibroproliferative Vascular Wound Healing From Deficiency of Type Iii Collagen: A Paradoxical Mechanism For Tissue Fragility
… injury and thrombus formation following ligation of the carotid artery reveals an abnormal persistence and elevated burden of occlusive thrombi at 21 post-operative days in vessels from <em>Col3a1<sup>+/-</sup></em> mice, as opposed to near complete resolution and formation of a patent …
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Heterogeneity in vascular smooth muscle cell gene expression and its association with clonal proliferation in models of vascular disease
… aorta and two in vivo disease models (CL – carotid ligation and HFD – high-fat diet-induced atherosclerosis). This identified VSMCs expressing stem cell antigen-1 (Sca1), which lacked expression of conventional VSMC markers, but were also distinct from adventitial and endothelial cell …
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Vascular smooth muscle cell heterogeneity and plasticity in models of cardiovascular disease
Vascular smooth muscle cell (VSMC) accumulation is a hallmark of atherosclerosis and vascular injury. However, fundamental aspects of proliferation and the phenotypic changes within individual VSMCs, which underlie vascular disease remain unresolved. In particular, it is not known if all VSMCs …