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Showing 1 to 20 of 69 for “"carnitine"”.
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Carnitine for lactating dairy cows
… to determine the effects of supplemental carnitine for lactating dairy cows. In the first experiment, carnitine (ca. 6 g/d) was administered into either the rumen or abomasum. Concentrations of carnitine in milk, plasma, liver, and urine increased similarly for both sites of carnitine …
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Studies on the Physiology of Carnitine
Made available in DSpace on 2014-12-05T21:33:53Z (GMT). No. of bitstreams: 1 0013528.pdf: 3344038 bytes, checksum: eca533a5441412a18f5f7594ee97b3b5 (MD5) Previous issue date: 1955
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L-Carnitine Supplementation for Periparturient Dairy Cows
L-Carnitine is required for mitochondrial oxidation of long-chain fatty acids. The objectives of this research were to determine whether L-carnitine supplementation increases hepatic fatty acid oxidation and decreases liver lipid accumulation in dairy cows. In experiment 1, 8 mid-lactation cows …
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Role of Acetyl-L-Carnitine in Hepatic Encephalopathy
… the symptoms of hepatic encephalopathy. Acetyl-L-carnitine, the short-chain ester of carnitine is endogenously produced within mitochondria and peroxisomes and is involved in the transport of acetyl-moieties across the membranes of these organelles. Acetyl-L-carnitine administration has shown the …
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Choline Acetyltransferase and Carnitine Acetyltransferase Activity in Human Spermatozoa During Capacitation
<p>The regional distribution of ChAT activity in human spermatozoa is altered during in vitro capacitation and it correlates with the fertilizing potential of sperm.</p> <p>Regional immunoreactivity in human spermatozoa as assessed by fluorescent immunocytochemistry was compared with ChAT and CaAT …
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Towards the Design of Carnitine Acyltransferase Inhibitors: Modeling the Conformational Behavior of (<em>R</em>)-Carnitine, (<em>R</em>)-Acetylcarnitine, Morpholinium rings, and 2-Oxo-1,3,6-dioxazaphosphacinium rings
… (AM1 and AM1/COSMO) on zwitterionic acetylcarnitine and carnitine, cationic acetylcholine and choline, and 3-acetoxypropanoate and 3-hydroxypropanoate in the gas phase and solution were performed. The calculated ΔH<sub>hydr</sub> for hydrolyses of acetylcarnitine to carnitine and of …
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Protein-energy and carnitine status in patients with upper aerodigestive tract cancer
… protein-energy malnutrition, alteration of carnitine status and an inadequate ascorbic acid status. We also observed an effect of tumour localization and tumour stage on the protein-energy status of the patients. Patients with pharyngeal cancer tended to have lower serum RBP concentration …
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Effects of carnitine on medium-chain fatty acid metabolism in newborn pigs
… acids (MCFA) is considered to be independent of carnitine because of their passive diffusion into the mitochondrion. However, upon feeding medium-chain triglycerides (MCT) to piglets (n = 16) followed by serial blood sampling, we observed significant changes in free and acyl-carnitines in plasma …
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The role of L-carnitine in preventing mitochondrial dysfunction after neonatal hypoxia-ischemia
… leading to metabolic crisis and apoptosis. L-carnitine (LCAR) is an endogenous compound that transports fatty acids across the mitochondrial membrane for metabolism, buffers endogenous acyl-coA pools and improves the health and efficiency of the mitochondria. In light of the mitochondrial …
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The role of L-carnitine in preventing mitochondrial dysfunction after neonatal hypoxia-ischemia
… leading to metabolic crisis and apoptosis. L-carnitine (LCAR) is an endogenous compound that transports fatty acids across the mitochondrial membrane for metabolism, buffers endogenous acyl-coA pools and improves the health and efficiency of the mitochondria. In light of the mitochondrial …
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Carnitine and Altered Lipid Metabolism in Iron-Deficient Rats Pre- and Postweaning (Ketogenesis)
… rat impairs the iron-dependent synthesis of carnitine, thereby shunting long-chain fatty acids away from oxidation and ketogenesis into triglyceride synthesis increasing triglyceride levels in serum and liver. The rationale for carnitine involvement is based on two facts: (1) carnitine …
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Investigating the Influence of Fresh and Aged Garlic Extracts on the Biosynthesis of Trimethylamine N-Oxide
… bacteria on dietary precursors including L-carnitine. Dietary supplementation of bioactive garlic phytochemical allicin has recently been suggested to reduce the formation of TMAO precursor molecule trimethylamine (TMA) from L-carnitine through impact on the intestinal bacteria, thereby …
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Enhancing Boar Reproductive Performance for Purposes of Artificial Insemination
… and 2) determine the effects of dietary L-carnitine supplementation on boar libido, semen quality, sperm production, and maintenance of sperm motility during liquid storage. Experiment 1 utilized lean-type, terminal-line boars (National Pig Development, Roanoke Rapids, NC) (n = 40; 177.4 ± …
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Metabolomic Insights into the Pharmacological and Genetic Inhibition of Cyclooxygenase-2
… the pathogenesis of coxib-induced HF. L-Carnitine shuttles activated long-chain fatty acids (FAs) across the inner mitochondrial membrane to the mitochondrial matrix, where they are oxidised by β-oxidation. This is especially important in the heart, which derives the majority of its …
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Effects of Temperature and Thyroid Hormone on Oxidative and Lipid Metabolism in Juvenile Lake Whitefish (Coregonus Clupeaformis)
… on mitochondrial -oxidation enzyme isoforms, carnitine palmitoyltransferase and carnitine palmitoyltransferase , combined with a decline in citrate synthase and cytochrome c oxidase activities, suggests that exposure to elevated temperature used in this study did not significantly increase …
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The Effects of 3-Phosphoglycerate and Other Metabolites on the Activation of AMP-Activated Protein Kinase by LKB1/STRAD/MO25
… (G1,6-P2), adenosine diphosphate (ADP), carnitine (Carn), acetyl-carnitine (Acarn), inosine monophosphate (IMP), inosine, and ammonia for allosteric regulation. We found that 3PG stimulated LKB1-STRAD-MO25 activity and allowed for increased AMPK phosphorylation. 3PG did not stimulate …
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Investigating the Impact of Metabolic Dysregulation on Nervous System Development and Function: A Study of CPT2 Deficiency in a Zebrafish Model System
… range of clinical presentations may develop. Carnitine Palmitoyltransferase (CPT) 2 is involved in the carnitine shuttle pathway and allows long-chain fatty acids (LCFAs) to undergo β-oxidation for ATP production. CPT2 deficiency is a disorder of fatty acid transport across the mitochondrial …
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Studies of the expression and characterization of various transport systems at RBE4 cells, an in vitro model of the blood-brain barrier
… 5-HT transporter (SERT) and the organic cation/carnitine transporter OCTN2, was shown at the RBE4 cells. Uptake studies with radiolabeled 5-HT exhibited a saturable, sodium dependent transport at RBE4 cells with a Kt value of about 0.40 µM and a Vmax of about 52 fmol/mg/min. L-carnitine and TEA …
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Lipid Quantification and Cryopreservation of In Vitro Produced Jersey Cattle Embryos
… been shown to induce lipolysis in IVP embryos. L-carnitine is required for transport of fatty acids from the intermembrane space of the mitochondria into the mitochondrial matrix to support the process of β-oxidation, and enhances ATP production. We hypothesized that the lipid content of in …
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