Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"cargo delivery"”.
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Amorphous calcium phosphate nanoparticles for biomedical cargo delivery
Oral delivery of intact biomolecules is desirable but challenging. This thesis presents a potential approach, using amorphous calcium phosphate (ACP) nanoparticles as carriers of organic cargo. ACP is widely used as an in vitro delivery vehicle but similar in vivo use has not been realised. This …
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Cargo delivery into gram-negative bacteria via enterobactin uptake machinery
… of this Chapter. Chapter 2. Siderophore-mediated Cargo Delivery to the Cytoplasm of Escherichia coli and Pseudomonas aeruginosa: Syntheses of Monofunctionalized Enterobactin Scaffolds and Evaluation of Enterobactin-cargo Conjugate Uptake This Chapter describes the design and syntheses of …
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Platelet Dense Granules Mature Within Late Stages Of Megakaryocyte Differentiation By Cargo Delivery
Platelet dense granules (DGs) are storage organelles for calcium ions, small organic molecules such as ADP and serotonin, and larger polyphosphates that are secreted upon platelet stimulation to enhance platelet activation, adhesion, and stabilization at sites of vascular damage. However, the …
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Block Copolymer Solutions: Transport and Dynamics, Targeted Cargo Delivery, and Molecular Partitioning and Exchange
… fields including packaging, electrolytes, delivery devices, and biosensors. Multiple investigations have been carried out on polymeric materials for cargo delivery purpose to understand how they behave over time. Block copolymer micelles (BCMs) have demonstrated superiority to deliver …
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Development of a cargo delivery system and inhibition studies focused on clostridium difficile toxin a
… medical views. Along with a review on existing cargo delivery systems utilizing protein toxins and the usefulness of such a system, here is described the first reported Clostridium difficile toxin A fusion protein, luciferase-TcdA, and evidence of the successful transport of an active enzyme, …
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Guidance, Navigation and Control of a Fly-By-Wire Transport Category Airship Designed for Hover Cargo Delivery
… position, heading, and attitude during hover and cargo operations. Owing to the large body area, most airships require that they be pointed into the wind to maintain their position. This research aims at controlling an airship attitude and position during hover cargo delivery, irrespective of the …
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Comparative analysis of cytotoxic necrotizing factor (CNF) toxins: Compatibility of cargo with delivery vehicle and identification of amino acid residues that modulate pH-dependent cytosolic cargo delivery
… modular proteins that deliver their catalytic cargo into the cytosol of host cells. These toxins are increasingly being exploited for targeted delivery in biomedical and research applications due to their potency and cell specificity. This thesis explores the suitability of the cytotoxic …
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Skyflower: A Reusable Tethered Lunar Landing System
… efforts primarily address small-scale payload delivery or crewed missions. The current state of the art lacks dedicated solutions for high-mass, uncrewed cargo delivery—a critical gap for enabling infrastructure deployment, in-situ resource utilization, and sustained lunar operations. This …
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Design of Human Serum Albumin and Adenovirus Conjugation via Catcher/Tag Molecular Glue
<p>Adenovirus (Ad) has been the ideal cargo delivery mechanism, and its moderate immunological response makes it ideal for in vivo gene therapies since its discovery in 1953. However, the robust immunogenicity of the Ad capsid and low vaccine absorption via mucous membranes and epithelium put a …
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The preparation of cucurbit[8]uril-based hydrogels for delivery applications
… chemistry of cucurbit[8]uril for the controlled delivery of molecular cargo. The host molecule is capable of binding two guest molecules in an inclusion complex. Its addition to an aqueous solution of guest-functional polymers leads to the formation of cross-links and hydrogels. The first results …
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Reinforcement Learning and Planning for Preference Balancing Tasks
… done on several robotic problems, such as Aerial Cargo Delivery, Multi-Agent Pursuit, Rendezvous, and Inverted Flying Pendulum both in simulation and experimentally. Additionally, PEARL is leveraged outside of robotics as an array sorting agent. The results demonstrate high accuracy and fast …
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Transcending the Cell Fate Stereotype: Cell Penetrating Peptide Technology helps Induce Pluripotency in Multiple Cell Types
… cells and subsequent tumorigenic effects. Direct delivery of reprogramming factor proteins via cell penetrating peptides (CPPs) overcomes these issues, however, endosomal entrapment commonly results in inefficient cargo delivery. These reprogramming protocols produce inefficient results that lack …
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Development of Bacteria-Based Bio-Hybrid Delivery Systems: Fabrication, and Characterization of Chemotaxis and Quorum Sensing
… and communication modules for micro/nanoscale cargo-carrying vehicles by integrating live prokaryotic or eukaryotic cells with synthetic objects. More specifically, because micro/nanoparticles are able to transport cargos efficiently and bacteria can play the role of targeted and selective …
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Engineered Polydopamine Nanocarriers for Biomedical Applications
… challenges persist. These include limited cargo delivery due to uncontrolled drug release, off-target toxicity, premature aggregation, and rapid clearance of nano-formulations. Among the nanomaterials explored, organic nanostructures such as polydopamine (PDA) nanoparticles have emerged as …
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Designer DNA Condensates: From Multiphase Architectures to Synthetic Exosome Release
… for advanced biomimetic materials and targeted cargo release, bridging insights into self-assembly with practical biotechnological solutions. The first part of this work addresses the biophysical principles underpinning the emergence of multi-phase biomolecular condensates, which are critical …
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Characterization and cooperative dynamics of kinesin motor proteins in intracellular transport
… defined stoichiometry and geometry on a rigid cargo-like platform. Together, these advances provided a programmable experimental system for dissecting how kinesin-1 ensembles and mixed kinesin-1/kinesin-14 assemblies behave under well-defined structural conditions.Using this platform, I found …
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Novel Cell Penetrating Peptides Effect Endosomal Escape and Deliver Protein Cargos into Living Cells
… penetration of the plasma membrane, allowing delivery of macromolecular cargoes to the cell interior. We have developed a novel CPP-adaptor protein technology that allows any user-defined cargo delivery and release into the cytoplasm. Our hypothesis<strong> </strong>is that a CPP-adaptor with …
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Ionic Mechanism of Lysosomal Function and Cell Metabolism
… I show that TPCs are critical for appropriate cargo delivery to the lysosomes and deletion of either TPC1 or TPC2 leads to delayed clearance of autophagosomes, resulting in enlarged lysosomes and accumulated contents inside the lysosomes. Cells with both TPC deleted also exhibit 50% reduction …
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DEVELOPMENT OF A NANOPARTICLE-BASED PLATFORM FOR THE DELIVERY OF THERANOSTIC AGENTS TO TUMOR TISSUE: TOWARD CLINICAL TRANSLATION
The selective delivery of anticancer agents to tumor tissue remains a major challenge in oncology, as many clinically effective drugs are limited by poor tumor specificity and dose-limiting systemic toxicity. Previous studies from the laboratory have explored the use of tumor-derived and …
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Anaplasma phagocytophilum remodels its host cell-derived vacuole into a protective niche by redecorating the vacuolar membrane with select Rab GTPases and bacterial proteins
… many aspects of endocytic and exocytic cargo delivery. We determined that the A. phagocytophilum-occupied vacuole (ApV) selectively recruits a subset of fluorescently-tagged Rabs that are predominantly associated with recycling endosomes. Another emerging theme among vacuole-adapted …
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