Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"cardiovascular physiology"”.
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Endothelin system in human cardiovascular physiology and pathophysiology
… a wish to better understand the pharmacology and physiology of the endothelin (ET) system in human blood vessels in health, and the influence of cardiovascular disease on the ET system. This work followed from the discovery of ET-1 as a peptide endothelial mediator of vascular tone in 1988. …
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Prenatal Cardiovascular Physiology and Early Neurodevelopment in Cyanotic Congenital Heart Disease
Advancements in infant cardiovascular surgery have resulted in a significant decrease in mortality of many newborns with congenital heart disease (CHD); however, neurodevelopmental delays and disorders (NDD) are common comorbidities. Studies have demonstrated delays in brain growth and maturation …
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Studies on the role of GPR55 in cardiovascular physiology and pathophysiology.
… currently unknown is if GPR55 has a role in the cardiovascular remodelling and cardiac function of atherosclerosis prone mice. To address this, the present studies were conducted to investigate 1) the role of GPR55 in atherogenesis, 2) if GPR55 has a role in the cardiac function of mice suffering …
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Nesfatin-1 Regulation of Cardiovascular Functions in Zebrafish and HL-1 Cardiomyocytes
… nesfatin-1 is also involved in modulating cardiovascular functions in rodents. Intracereberoventricular injection of nesfatin-1 increased mean arterial pressure in rats. In rats, nesfatin-1 acts as a post-conditioning agent and elicits cardioprotection against ischemia-reperfusion injury. …
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Development and analysis of a simple grey-box model of central sleep apnea
… a simple grey-box model that describes the pathophysiology of central sleep apnea (CSA). We construct our model following a thorough survey of published approaches. Special attention is given to PNEUMA, a complex, comprehensive model of human respiratory and cardiovascular physiology that brings …
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Kinematic Characterization of Left Ventricular Chamber Stiffness and Relaxation
… a unique method with which to characterize cardiovascular physiology, specifically diastolic function (DF). The advantage of an approach that is standard in physics, such as the kinematic modeling is its causal formulation that functions in contrast to correlative approaches traditionally …
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Estimation of cardiovascular indices by analysis of the arterial blood pressure signal
… (ABP) signal. The algorithms incorporate cardiovascular physiology within the framework of a generalized Windkessel model, which is a widely accepted cardiovascular model. Algorithms to identify end systole were also developed and implemented in the new and existing SV, CO, and TPR …
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The effects of early life nutrient restriction on the cardiovascular system of the adult sheep
… life is linked with a higher incidence of cardiovascular disease in adulthood. The physiological processes involved are not yet clear. The aim of this thesis was to investigate how aspects of the cardiovascular system in the adult sheep are affected by early life periods of undernutrition, …
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Acidosis Activated GPR68 Promotes Vascular Smooth Muscle Cell Growth
Cardiovascular disease (CVD) is the primary cause of death in the United States and worldwide. Localized extracellular acidosis has been theorized as a possible contributor to CVD pathogenesis, but its precise impact remains unclear. G protein coupled receptors (GPCRs) are seven transmembrane …
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Effects of Food Consumption on Cell Proliferation in the Brain of Python regius
… impressive plasticity in their digestive and cardiovascular physiology due to the sheer magnitude of the increase in organ growth that occurs after a meal to speed digestion, absorption, and assimilation of nutrients. While this systemic growth in response following food consumption is well …
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Fetal origins of cardiovascular dysfunction in an ovine model of maternal obesity in pregnancy
… pregnancy to investigate its impacts on fetal cardiovascular physiology. We adopted an integrative approach, combining experiments of fetal cardiovascular function in vivo following surgical instrumentation with investigation at the isolated organ, cellular and molecular levels. Maternal …
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Cardiovascular reactivity in men as a function of masculine gender role stress, Type-A behavior, and hostility
… with a set of physiological responses known as cardiovascular reactivity. Generally, such reactivity is measured in terms of systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR). Cardiovascular hyper-reactivity has been implicated as the major pathogenic mechanism …
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Simple Tests for Assessing Kidney and Cardiovascular Function in Chromic Kidney Disease Patients (Stages 2, 3 and 4)
… of risk factors for progression of CKD linked to cardiovascular disease (CVD) remains difficult, particularly in older subjects. To address this GFR and the cardiovascular parameters arterial stiffness, heart rate variability (HRV) and natriuretic peptides (NT- proBNP and NT-proCNP) were measured …
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Kinematic Modeling of the Determinants of Diastolic Function
… used in clinical cardiology to determine cardiovascular function, and many of the indexes derived from these modalities are causally interconnected. A correlative approach to cardiovascular function however, where indexes are correlated to disease presence and progression, fails to fully …
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Genetic dissection of essential hypertension and familial intracranial aneurysm
… and animal model studies and the cluster of cardiovascular candidate genes located there. Eleven microsatellites across 55 cM of 5q31.1 to qter were genotyped in 212 hypertensive nuclear families of the Silesian Hypertension Study. Two-point and multipoint analyses showed linkage of a 7 cM …
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Physiology-inspired deep learning for improved heart failure management
… trust and adoption. In this thesis, we propose physiology-inspired deep learning approaches to improve heart failure management. Central hemodynamic parameters are typically measured via pulmonary artery catheterization — an invasive procedure that involves some risk to the patient and is not …
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Cardiovascular, autonomic and neuropathic physiology and their involvement in the extra-articular manifestations of hypermobility disorders
… Therefore, this thesis focuses on potential pathophysiology relating hypermobility with the extra-articular manifestations and how this differs from the ‘normal’ physiology of healthy individuals. The initial chapters address the utility of a commercially available device (SphygmoCor, AtCor …
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The role of prostaglandins, nitric oxide and oxygen in the ductus arteriosi of the pre-term chicken embryo (Gallus domesticus).
The chicken ductus arteriosi (DA) are two embryonic blood vessels that shunt blood away from the non-ventilated lungs and towards the body and chorioallantoic membrane. I show that prostaglandins have a diminished role in maintaining chicken DA patency and nitric oxide inhibits oxygen induced …
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Direct Effect of Glucocorticoids on the Developing Cardiovascular System: Studies in the Chicken Embryo
… may have a detrimental effect on the fetal cardiovascular system. The chicken embryo model was used to establish a clinically relevant glucocorticoid treatment at two thirds of development, without compounding influence of maternal or placental physiology, such that the direct effect of …
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G Protein-Coupled Receptor Signaling in Growth and Inflammation of Vascular Smooth Muscle
Cardiovascular disease (CVD) remains the primary cause of morbidity and mortality in the United States and worldwide. The exaggerated release of serine proteases and reduced blood flow and ensuing development of extracellular acidosis in affected tissues have previously been theorized to contribute …