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Showing 1 to 19 of 19 for “"cardioprotective effect"”.
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Exploring the cardioprotective effect of synthetic wine in Long Evans rats
… Therefore, the delineation of the putative cardioprotective components in wine such as alcohol, resveratrol and melatonin is very challenging when using commercially available red wine. Aim: We aimed to use synthetic wine, whose composition is well characterized, to explore whether the …
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The Cardioprotective effect of a Lanosteryl Triterpene from Protorhus Longifolia on H9c2 Cardiomyoblasts
… model. However, no mechanism associated with its cardioprotective potential has been proposed. Aim: In this study, we aimed to assess the mechanism by which methyl-3βhydroxylanosta-9,24-dien-21-oate (RA3) is able to improve glucose uptake, whilst decreasing lipotoxicity, oxidative stress, insulin …
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Cardioprotective Effect of Onion Extract against Ischemic Injury In vitro and In vivo
… to have a potential to reduce the detrimental effect of cardiovascular risk factors, and their beneficial roles are suggested to be associated with antioxidant mechanism. Compared to garlic, very few have been reported about the myocardial beneficial effect of onion. Based on these …
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Potential cardioprotective effect of chronic, moderate consumption of reduced-alcohol wine in a rat model of pulmonary hypertension
… wine has powerful antioxidant properties and is cardioprotective. However, side effects of alcohol may limit the use of wine as a therapeutic agent. The aim of this study was to test whether reduced-alcohol red wine (RARW) or regular red wine (RW) consumption would limit monocrotaline …
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Cardioprotective Effect of Lipid Emulsion on Acute Exogenous Drug Intoxications // Кардиопротективен ефект на липидна емулсия при остри екзогенни интоксикации с медикаменти
… introduction into the routine practice of more effective treatments such as intravenous lipid emulsions (LE). Initially, LEs were developed to meet the necessity for essential fatty acids in patients receiving parenteral nutrition. In the last 15 years, a new effect of LE has been discovered, …
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The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection
… present in wine, may contribute to this cardioprotective effect. Melatonin confers cardioprotection via the activation of tumor necrosis factoralpha (TNF-α) and the signal transducer and activator of transcription-3(STAT-3), via mechanisms that still remain to be delineated. We therefore …
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Role of Tumour Necrosis Factor Alpha (TNFa) in ischaemic and pharmacological postconditioning
… the exact signalling pathway involved in this cardioprotective effect still remains unclear.
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The role of melatonin in red wine-induced cardioprotection
… exact components in red wine that confer this effect are unclear. Previous studies performed in our laboratory suggest that neither the well-known polyphenol resveratrol nor alcohol (12%) present in red wine contribute to the cardioprotective effect of red wine when administered chronically, on …
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Long-term cardioprotection with phosphodiesterase-5 inhibition against ischemia-reperfusion injury: Role of nitric oxide.
… sildenafil citrate, induces a powerful cardioprotective effect against ischemia-reperfusion (I/R) injury in rabbit and mouse hearts. However, the effect of this drug in inducing long-term protection against I/R injury remains unknown. The goal of this study was to identify the duration …
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Pharmacological interventions against myocardial ischemia and reperfusion injury
… reperfusion injury. Even though promising cardioprotective strategies have been presented in the pre-clinical setting, experience from the clinic has been largely disappointing. Aims: To investigate whether two different pharmacological interventions, cyclosporine A (CsA) and the novel …
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Kardioprotektion durch Veränderung des Zytoskelettes im Langendorff-Hypoxie-Modell der Ratte
… drugs which are also combined together. The effects of different drugs on the cytoskeleton, before all in the ischaemic phase, are examined on a biochemical basis with the help of the creatine kinase release and on a histological basis with the help of the apoptotic properties of the …
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Myocardial ischemia-reperfusion and cardioprotection. A study with microdialysis in a porcine model.
… to start during the ischemia, reduced the effect of ischemia on the myocardial metabolism, improved, and preserved cardiac performance during this period. In recent years, concerns with the use of perioperative beta-blockers have been debated. Beta-blockers may inhibit the pharmacological …
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The effect of Aspalathin on Doxorubicin-induced Cardiotoxicity
Doxorubicin is a highly effective first-line chemotherapeutic agent used in the treatment of a broad range of solid and hematological tumors. Though effective, the use of Doxorubicin in cancer therapy has been hindered by its cardio toxic side effects. As yet, no single chemical synthesized drug or …
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Novel Strategies in Cardioprotection against Ischemia/Reperfusion Injury
… via opening of mitoKATP channels. The acute cardioprotective effect of sildenafil was dependent on activation of protein kinase C in rabbits. Moreover, we observed that sildenafil induced delayed PC by NO produced through activation of inducible nitric oxide synthase (iNOS) and endothelial …
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Pharmacological activation of pro-survival pathways as a strategy for improving donor heart preservation
… preservation. The first study investigated the cardioprotective effects of a novel inhibitor of poly(ADP-ribose) polymerase 1, INO-1153. Maximum protective effect (after a 6 hour storage period) was observed when the PARP inhibitor was administered prior to cardiac arrest and storage and when …
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CARDIAC ENERGY METABOLISM IN ISCHAEMIA AND TYPE 1 DIABETES
… with dietary nitrate ablated this cardioprotective effect, but this highlights the importance of fatty acid oxidation to recovery from ischaemia/reperfusion injury. Ketogenesis was found to occur in the ischaemic heart, and was not specifically dependent upon either fatty acid or …
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Melatonin's Protection against DNA Damage by the Iron (III)-Adriamycin Complex.
… soft tissue carcinomas. Adriamycin is a highly effective anti-cancer drug. It has a fused ring system that is planar, hydrophobic and electron rich. These features allow intercalation into DNA which, along with its topoisomerase inhibition, results in its anti-cancer effectiveness. Despite its …
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Investigating the possible cytoprotective effects of melatonin isomer against simulated ischemic injury
… presence of melatonin in wine contributes to the cardioprotective effect of regular and moderate consumption of wine against lethal ischemia/reperfusion injury. Recently, the presence of melatonin isomers has been identified in red wine, but whether or not these isomers confer any physiological …
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Die Bedeutung der NO-Synthasen im murinen Modell der septischen Hämodynamik
… to examine the nitrogen-oxide-mediated effects on septic haemodynamics in a murine CLP model and to clarify the significance attributable to the respective NO synthases in this connection. To this end, the following experiments were conducted in wild-type and eNOS-/- mice with and …