Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"cardiomyocyte differentiation"”.
-
An investigation into a role for follistatin in early cardiogenesis in Xenopus Laevis
… acid (RA) plays a crucial role in regulating cardiomyocyte differentiation and heart tube formation, but excess RA inhibits cardiomyocyte differentiation. We have used microarray technology and whole mount in situ hybridization to investigate the mechanism by which RA might alter …
-
Investigating the role of the cardiac apelin receptor using human embryonic stem cell derived-cardiomyocytes.
… cell type. This study aimed to use hESC-derived cardiomyocytes to examine the role of the apelin receptor in cardiomyocyte development and function. For the first time, hESC-derived cardiomyocytes were found to express the apelin receptor at similar levels to human hearts, indicating suitability …
-
Engineering poly(ethylene glycol) nanogel coatings: Developments in achieving ultralow protein adsorption and applications as substrates for stem cell culture
… the direct reprogramming of fibroblasts to cardiomyocytes over the standard stem cell substratum of Matrigel and revealed insight into optimal cellular organizations for cardiomyocyte differentiation. However, we also unexpectedly found that adsorption of laminin to mercaptosilanated glass …
-
Characterizing the effects of in utero exposure to valproic acid on murine fetal heart development
… involved in development of cardiac structure and cardiomyocyte differentiation, has been shown to increase in response to in utero VPA exposure. Furthermore, this increase in gene expression has been associated with contractile dysfunction and myocardial disorganization. To characterize the …
-
Defining The Molecular Networks Necessary For Thymus Fate and Organogenesis
… factors are required for organ-specific differentiation, the exact molecular mechanisms that specify endodermal progenitors to either the thymus or parathyroid lineage are not well defined. <em>Tbx1</em> is initially expressed throughout the 3<sup>rd</sup> pp endoderm, as it is required …