Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"cardiogenesis"”.
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Characterization of the cardiogenesis of embryonic stem cells
… of how individual stimulations can affect the cardiogenesis process of embryonic stem cells. First, a compliant microfluidic system was developed to study the individual and combined effects of culture dimensions and uniaxial cyclic stretch on the differentiation process. A smaller culture …
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BUBR1 in Cardiac Biology: From Cardiogenesis to Adult Heart Function and Aging
… differentiation trajectories, suppressed cardiogenesis genes, and hyperactivation of Wnt signaling in cardiac specific BubR1 knockout embryonic hearts, underscoring the critical role of BubR1 in maintaining signaling homeostasis during heart morphogenesis. Beyond cardiac development, we …
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An investigation into a role for follistatin in early cardiogenesis in Xenopus Laevis
… the mechanism by which RA might alter cardiogenesis. Our results showed that RA inhibits cardiomyocyte differentiation at least partially through increasing follistatin gene expression and decreasing BMP signaling. Using cultured explants of the heart region, we demonstrated that …
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Characterisation of the role of Sox4 in mouse embryonic development
The molecular complexity of cardiogenesis is revealed by the high incidence of heart phenotypes resulting from mutation to any of a vast number of genes across multiple pathways. Many proteins, in pathways critical for correct embryonic patterning, are thus also identified as playing a role in …
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The epigenetics and role of Dopa Decarboxylase in heart development
… in fetal heart development. The role of Ddc in cardiogenesis is explored using knockout mice lacking Ddc_exonla expression in heart. Expression microarrays were used to detect changes in gene expression, and morphometric analysis using 3D imaging was performed to look for gross morphological …
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Colocalization between Akirin, the NuRD Complex, and Histone Modifications
… remodeling complex during myogenesis and cardiogenesis. Interaction between Akirin and CHD family chromatin remodeling complexes has not been determined.</p> <p>Our study aimed to examine the colocalization of Akirin with the CHD family chromatin remodeling complex known as the nucleosome …
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Perspectives On Ethanol Toxicity In Medaka Embryogenesis And Possible Protection By Asian Ginseng (Panax Ginseng): Histological And Biochemical Analysis
… to explore alcohol's effect on neurogenesis, cardiogenesis, intracellular signaling, neurobehavioral aspects, and apoptosis. These two fish models have proven utility for studying alcohol's damaging effects during morphogenesis. In this study we have demonstrated that exposing Japanese medaka …
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Transcriptional Profiling of Early Cardiac Development
Cardiogenesis is an intricate process that spans nearly the entire developmental history of the mammal. A thorough comprehension of the molecular interactions that direct cardiac development will improve our ability to understand and treat cardiovascular diseases. The earliest stages of heart …
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Characterizing the effects of in utero exposure to valproic acid on murine fetal heart development
… of transcription factors associated with cardiogenesis. Myocyte enhancing factor 2C (Mef2c), a transcription factor involved in development of cardiac structure and cardiomyocyte differentiation, has been shown to increase in response to in utero VPA exposure. Furthermore, this increase in …
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Transcriptional Regulation of Cardio-Pulmonary Development
… genetic dissection of the pathways involved in cardiogenesis, have shown a striking similarity in molecular mechanisms across species. One conserved protein is dHAND, a basic helix-loop-helix (bHLH) transcription factor that is required for normal development of the right ventricle, the …
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Multifunctional Regulators of Cardiac Disease and Development
… show that key transcriptional regulators of cardiogenesis play a significant role not only in heart development, but also in development of other organs. These findings imply that combinatorial actions of transcriptional regulators in a tissue-specific manner are critical in embryogenesis.
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A multi-lineage in vitro mouse embryo model derived exclusively from mouse embryonic stem cells
… and aspects of gastrulation, somitogenesis, cardiogenesis, and neurulation. However, it fails to recapitulate the spatiotemporal interplay of signalling pathways between embryonic and extraembryonic tissues. Another approach is to combine ESCs with extraembryonic stem cells (trophoblast stem …
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A study on the role of oxidative stress and protein kinase signalling in hyperglycaemia induced cardiac remodelling
… different MAPKs, the p38 MAPKs are involved in cardiogenesis and implicated in stimulating myocyte apoptosis, hypertrophy, or even antiapoptotic effects. As such, the role of p38 MAPKs in diabetic cardiac remodelling, especially during cardiac development, remains unclear. This study aims to …
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Elucidation of the Cardiac Myogenesis Regulatory Network
… a loosely stitched cross-evolutionary view of cardiogenesis that leaves much to be desired by way of completeness. Thus, in order to move toward a comprehensive model of heart development, we have a critical need for global network views of heart development processes conducted within one …
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Spatially-resolved multiomic profiling of the human heart in adulthood and development
The human heart is composed of a multitude of cell types that must work in a coordinated fashion to achieve tissue and organ functions. Single-cell genomics is a powerful framework for characterising cell and tissue biology, including functional gene programmes, regulatory networks, and cell-cell …
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Regulation and patterning of cell differentiation and pluripotency
… therapy, and enable controlled in vitro study of cardiogenesis. In the second project, we developed a novel patterning strategy by using inducible gene expression systems in conjunction with simple multi-laminar fluidic techniques, which can directly pattern the expression of particular gene at …
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Src Kinase Regulates TGFβ And Hyaluronan Induced Epicardial Cell Invasion, Differentiation And Migration
… lethal at E 9.5 as a result of severely blocked cardiogenesis due to insufficient endocardial EMT. HA serves structural and bioactive functions in its capacity to stimulate signal transduction pathways required for EMT. Src kinase is a non-receptor tyrosine kinase well characterized to function …
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Anteriore Musterbildung im Wirbeltierembryo - Die Induktion von Vorderhirn und Herz
Keimblätter und Körperachsen eines Wirbeltierembryos werden unter dem Einfluß eines regulatorischen Zentrums, des Organisators, etabliert. Sekretierte Signalmoleküle aus dem Organisator und von Zellen, die vom Organisator abstammen, können die Identität benachbarter Zellen bestimmen und nehmen …