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Showing 1 to 18 of 18 for “"cardiac troponin I"”.
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Development of Magnetic Nanoparticle-based Enrichment Techniques and Mass Spectrometry Methods for Quantification of the Clinical Biomarker Cardiac Troponin I
Human cardiac troponin I (cTnI) in serum is a well-known clinical biomarker for cardiac tissue damage and is used for diagnosing myocardial infarction. Unfortunately, commercial cTnI immunoassays from different manufacturers can produce significantly different measurement results for the same …
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Cardiac biomarkers (NT-proBNP and cardiac troponin-I) and point-of-care ultrasound in dogs with cardiac and non-cardiac causes of non-hemorrhagic ascites
… Non-hemorrhagic ascites (NHA) can be caused by cardiac diseases (cNHA) and non-cardiac diseases (ncNHA). N-terminal brain natriuretic peptide (NT-proBNP), cardiac troponin-I (cTnI) and point-of-care ultrasound (POCUS) may differentiate between cNHA and ncNHA. Hypothesis/Objectives: This study …
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Exploiting novel antibodies for the early detection of cardiac disease
… economic importance in healthcare provision. The cardiac troponins are definitive indicators of cardiovascular disease and elevated levels of cardiac troponin I (cTnI) are highly-specific for cardiovascular damage. Using a specific targeting strategy, a panel of novel antibodies were successfully …
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Investigating the link between post-tuberculosis lung disease (PTLD) and circulatory biomarkers in a South African cohort
… VEGF, angiopoietin-1, TBARS, NT-pro-BNP, and cardiac troponin-I, in patients stratified by the number of previous TB episodes and the time since the last treatment. VEGF and angiopoietin-1 were significantly elevated (up to 6500-fold above normal), with positive correlations to TB episode …
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Development of a fluorescence resonance energy transfer optical nanoscale biosensor based on a liquid-core waveguide platform
… and Respiratory Syndrome virus and human cardiac Troponin I, showing ample sensitivity and a high degree of specificity, as well as rapid response.
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Prevalence of Occlusive Myocardial Infarction (OMI) in patients diagnosed with Non-ST-Elevation Myocardial Infarction (NSTEMI) at a single private facility in Cape Town, South Africa, during 2019
… in 2019, analysing descriptive data, serial cardiac troponin I (cTnI) results, the proportion undergoing angiography, Thrombolysis in Myocardial Infarction (TIMI) flow grades, and door-to-angiogram times. Methods: A cross-sectional, observational study was conducted using a retrospective …
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Prevalence of Occlusive Myocardial Infarction (OMI) in patients diagnosed with Non-ST-Elevation Myocardial Infarction (NSTEMI) at a single private facility in Cape Town, South Africa, during 2019
… in 2019, analysing descriptive data, serial cardiac troponin I (cTnI) results, the proportion undergoing angiography, Thrombolysis in Myocardial Infarction (TIMI) flow grades, and door-to-angiogram times. Methods: A cross-sectional, observational study was conducted using a retrospective …
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Characterisation of cardiac protein changes post death: pilot study
… biochemical changes that occur postmortem in cardiac tissues through analysis of proteins. Moreover, to determine if there was degradation in cardiac proteins post death for bodies with known time since death. Additionally, to determine the usability of PM cardiac tissues as controls for …
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Redox Regulation of Type Iα PKA in the Heart
… disulfide) potentiated isoprenaline-induced cardiac Troponin I phosphorylation. Inhibition of monoamine oxidase (MAO), which metabolises monoamines to generate hydrogen peroxide (H2O2), blocked monoamine-induced RIα oxidation. Echocardiography revealed that RIαCys17Ser „redox-dead‟ knock-in …
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Cardiac Biomarkers in Hyperthyroid Cats
… effects on the circulatory system. The cardiac biomarkers NT-proBNP and troponin I (cTNI) have proven useful in identifying cats with myocardial disease but have not been as extensively investigated in hyperthyroidism. Hypothesis: Plasma NT-proBNP and cTNI concentrations are higher in …
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Plasmonic Optical Sensors: Performance Analysis and Engineering Towards Biosensing
… applied to demonstrate the on-chip detection of cardiac troponin-I. (2) Plasmonic optical fibers are constructed by transferring periodic metal nanostructures from patterned templates onto endfaces of optical fibers using an epoxy adhesive. Patterned metal structures are generally extended from …
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An investigation into the mechanisms, consequences and moderators of intradialytic hypotension in paediatric haemodialysis
… peak stress at the end of HD. I found rising cardiac troponin I levels in 25% of the cohort and reduced regional LV function in all the children examined. The level of dysfunction significantly correlated with actual BP, the degree of intradialytic BP fall and UF volumes. What remains unclear …
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Defining feline brachycephaly and benefits of ala vestibuloplasty in the brachycephalic cat
… enrolled and assessed preoperatively by cardiac biomarkers (cardiac troponin-I [cTnI] and N-terminal-pro brain natriuretic peptide [NT ProBNP]), contrast echocardiography, airway computed tomography (CT), endoscopy, and a standardized owner questionnaire. Ala vestibuloplasty was performed …
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Modelling Brugada Syndrome using induced pluripotent stem cells
… hearts. The majority of mutations involve the cardiac sodium channel gene SCN5A and give rise to classical symptoms, which include an abnormal electrocardiogram with ST segment elevation and a predisposition to ventricular fibrillation. To date, the implantation of a cardioverter defibrillator …
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Multiplexed protein biomarker analysis on silicon photonic microring resonators: translation towards clinical diagnostics
… 5 describes the detection and quantitation of cardiac troponin I in serum samples from cardiac disease patients. Chapter 6 demonstrates the development of a multiplexed assay panel to detect 12 immunoregulatory markers associated with sepsis, as well as application of the panel to test plasma …
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Miniature bioanalytical assays utilizing mechanical actuation of microspheres
… demonstrate the ability of our assay to quantify cardiac troponin I (cTnI), an established biomarker for cardiac injury. Because elevated levels can indicate heart attack or other critical conditions, measuring cTnI accurately and rapidly is essential. cTnI is quantified via immunoaffinity …
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DIABETES IMPAIRS THERAPEUTIC EFFECT OF ENDOTHELIAL PROGENITOR CELL EXOSOME-MEDIATED MYOCARDIAL REPAIR
… endothelial progenitor cells (BM-EPCs) promote cardiac neovascularization and attenuate ischemic injury in animal models. Lately, emerging evidence supports that exosomes (Exo), a family of extracellular vesicles, mediate stem cell therapy by carrying cell-specific biological cargo and by …
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Peri-operative cardiac morbidity: prediction, prevention and the novel role of B-type natriuretic peptide
… have been utilised to attempt to predict the cardiac risk of surgery. Theoretically, accurate pre-operative risk stratification would allow patients at low risk to have their surgery expedited efficiently, whilst those at higher risk could have a change made to their treatment plan such as …