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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"cardiac troponin"”.
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Thermodynamic Investigation into the Binding Properties of Cardiac Troponin (Human and Bovine)
Troponin is an integral protein in the mechanism of muscle contraction. In order to induce cardiac muscle contraction, Ca[superscript]2[superscript]+ must bind to the TnC subunit (calcium binding subunit) of troponin to begin a conformational change in the protein. The ATPase rate of myosin with …
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A FRET Investigation into Molecular Mechanisms of Cardiac Troponin Activation in Reconstituted Thin Filaments
… regulated by intracellular Ca2+ concentration. Troponin (Tn), the Ca2+-binding protein in muscle, allosterically regulates actin and myosin interactions (crossbridge formation) by facilitating the release of two troponin I (TnI) actin binding sites at high Ca2+, the inhibitory region (IR) and …
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Versatile Aspects of Cardiac Troponin Assessment: Innovative Clinical Settings, Coronary Sinus Sampling, and Qualitative Laboratory Analyses
Contains fulltext : 249042.pdf (Publisher’s version ) (Open Access)
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Development of Magnetic Nanoparticle-based Enrichment Techniques and Mass Spectrometry Methods for Quantification of the Clinical Biomarker Cardiac Troponin I
Human cardiac troponin I (cTnI) in serum is a well-known clinical biomarker for cardiac tissue damage and is used for diagnosing myocardial infarction. Unfortunately, commercial cTnI immunoassays from different manufacturers can produce significantly different measurement results for the same …
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Cardiac biomarkers (NT-proBNP and cardiac troponin-I) and point-of-care ultrasound in dogs with cardiac and non-cardiac causes of non-hemorrhagic ascites
… Non-hemorrhagic ascites (NHA) can be caused by cardiac diseases (cNHA) and non-cardiac diseases (ncNHA). N-terminal brain natriuretic peptide (NT-proBNP), cardiac troponin-I (cTnI) and point-of-care ultrasound (POCUS) may differentiate between cNHA and ncNHA. Hypothesis/Objectives: This study …
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Exploiting novel antibodies for the early detection of cardiac disease
… economic importance in healthcare provision. The cardiac troponins are definitive indicators of cardiovascular disease and elevated levels of cardiac troponin I (cTnI) are highly-specific for cardiovascular damage. Using a specific targeting strategy, a panel of novel antibodies were successfully …
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Characterisation of cardiac protein changes post death: pilot study
… biochemical changes that occur postmortem in cardiac tissues through analysis of proteins. Moreover, to determine if there was degradation in cardiac proteins post death for bodies with known time since death. Additionally, to determine the usability of PM cardiac tissues as controls for …
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Investigating the link between post-tuberculosis lung disease (PTLD) and circulatory biomarkers in a South African cohort
… VEGF, angiopoietin-1, TBARS, NT-pro-BNP, and cardiac troponin-I, in patients stratified by the number of previous TB episodes and the time since the last treatment. VEGF and angiopoietin-1 were significantly elevated (up to 6500-fold above normal), with positive correlations to TB episode …
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Development of a fluorescence resonance energy transfer optical nanoscale biosensor based on a liquid-core waveguide platform
… and Respiratory Syndrome virus and human cardiac Troponin I, showing ample sensitivity and a high degree of specificity, as well as rapid response.
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Modelling Brugada Syndrome using induced pluripotent stem cells
… hearts. The majority of mutations involve the cardiac sodium channel gene SCN5A and give rise to classical symptoms, which include an abnormal electrocardiogram with ST segment elevation and a predisposition to ventricular fibrillation. To date, the implantation of a cardioverter defibrillator …
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Prevalence of Occlusive Myocardial Infarction (OMI) in patients diagnosed with Non-ST-Elevation Myocardial Infarction (NSTEMI) at a single private facility in Cape Town, South Africa, during 2019
… in 2019, analysing descriptive data, serial cardiac troponin I (cTnI) results, the proportion undergoing angiography, Thrombolysis in Myocardial Infarction (TIMI) flow grades, and door-to-angiogram times. Methods: A cross-sectional, observational study was conducted using a retrospective …
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Prevalence of Occlusive Myocardial Infarction (OMI) in patients diagnosed with Non-ST-Elevation Myocardial Infarction (NSTEMI) at a single private facility in Cape Town, South Africa, during 2019
… in 2019, analysing descriptive data, serial cardiac troponin I (cTnI) results, the proportion undergoing angiography, Thrombolysis in Myocardial Infarction (TIMI) flow grades, and door-to-angiogram times. Methods: A cross-sectional, observational study was conducted using a retrospective …
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Zebrafish cardiovascular cDNA microarrays : expression profiling and gene discovery in embryos exposed to 2,3,7,8-Tetrachlorodibenzo-ρ-dioxin
… system. Hallmarks of embryonic exposure include cardiac malformation, impaired circulation, loss of erythrocytes, pericardial and yolk sac edema, and early life stage mortality. However, the mechanism of TCDD cardiovascular embryotoxicity is poorly understood. The primary goal of this thesis was …
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Redox Regulation of Type Iα PKA in the Heart
… disulfide) potentiated isoprenaline-induced cardiac Troponin I phosphorylation. Inhibition of monoamine oxidase (MAO), which metabolises monoamines to generate hydrogen peroxide (H2O2), blocked monoamine-induced RIα oxidation. Echocardiography revealed that RIαCys17Ser „redox-dead‟ knock-in …
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Does acute hypoxia and high altitude exposure adversely affect cardiovascular performance?
… hypotheses 1. HA adversely affects biventricular cardiac function leading to an increase in estimated filling pressures which is influenced by the mode of hypoxia. 2. HA exposure leads to myocardial injury that is linked to the development of AMS. 3. HA exposure is associated with a reduction in …
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Plasmonic Optical Sensors: Performance Analysis and Engineering Towards Biosensing
… applied to demonstrate the on-chip detection of cardiac troponin-I. (2) Plasmonic optical fibers are constructed by transferring periodic metal nanostructures from patterned templates onto endfaces of optical fibers using an epoxy adhesive. Patterned metal structures are generally extended from …
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An investigation into the mechanisms, consequences and moderators of intradialytic hypotension in paediatric haemodialysis
… peak stress at the end of HD. I found rising cardiac troponin I levels in 25% of the cohort and reduced regional LV function in all the children examined. The level of dysfunction significantly correlated with actual BP, the degree of intradialytic BP fall and UF volumes. What remains unclear …
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Myocardial injury after non-cardiac surgery: A prevalence study
… healthcare systems. Myocardial injury after non-cardiac surgery (MINS) is a new entity that has recently been identified as an independent risk factor associated with 30-day all-cause mortality. The risk of death increases approximately 10 fold following MINS in the perioperative period. …
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Defining feline brachycephaly and benefits of ala vestibuloplasty in the brachycephalic cat
… enrolled and assessed preoperatively by cardiac biomarkers (cardiac troponin-I [cTnI] and N-terminal-pro brain natriuretic peptide [NT ProBNP]), contrast echocardiography, airway computed tomography (CT), endoscopy, and a standardized owner questionnaire. Ala vestibuloplasty was performed …
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