Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"cardiac transplantation"”.
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Enhancing Metabolism of Donor Hearts for Cardiac Transplantation
… a major cost to the health care system. Heart transplantation remains the most effective treatment for end-stage heart failure. However, transplantation can only be offered to a small fraction of patients with this disease due to the inadequate supply of available organs. A major factor …
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Molecular imaging of gene transduction in cardiac transplantation
… to target pathological processes following cardiac transplantation faces many challenges including the potential effects of the virus on the host as well as the need to establish the presence of the gene in the target organ. In the first set ofexperiments (Chapter 2), concerns over the …
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Coping and adjustment in persons with rheumatoid arthritis and cardiac transplantation.
… coping and psychosocial adjustment to illness in cardiac transplant recipients and patients with chronic rheumatoid arthritis. The research questions were: (1) What coping patterns and levels of adjustment to illness are identified by heart transplant patients and rheumatoid arthritis patients? …
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Infant Heart Transplant: Perioperative Indicators of Neurocognitive Development
… retrospectively examined 44 infants who received cardiac transplantation between 1985 and 1990 and had also received cognitive and academic assessment between 4 to 10 years of age. Results revealed that rewarming rate and DHCA times under 40 minutes did not correlate with intellectual outcome. …
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Development of Novel Macrophage Imaging Agents
… fast blood clearance times. In a heterotopic cardiac transplantation model of acute rejection the tracer 99mTc-SER4 demonstrated enhanced targeting to the rejected organ, whilst following recovery to localised bone marrow radioablation preliminary data showed increased 64Cu-NOTASER4 in the …
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Role of peroxisome proliferator-activated receptors in mechanisms of rejection in heart transplantation
… PPAR agonists in parenchymal rejection (PR) and transplantation-associated arteriosclerosis (TxAA). Four different PPAR agonists (fenofibrate and Wy14643 for PPARα; BRL69453 and 15-deoxy-[delta]¹⁴̹⁶ Prostaglandin-J₂ for PPAR[gamma]) in an in vitro model of the alloresponse all demonstrated a …
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The New Normal: A Bourdieusian Examination of Living into Young Adulthood being a Paediatric Heart Transplant Recipient
Improved success of paediatric cardiac transplantation has resulted in increased survival of recipients into young adulthood (19 to 29 years of age). Young adults who received a heart transplant during childhood have experienced multiple life sustaining procedures. As survival and longevity …
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CD4 T cell allorecognition pathways in acute and chronic allograft rejection
Solid organ transplantation is now an established and effective treatment option for end-stage organ failure. Whilst early outcomes have improved significantly over recent decades, longer-term outcomes have changed little. Despite advances in immunosuppression, most transplanted organs suffer an …
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A four-year study of cirrhosis at Groote Schuur hospital
… centre for certain services, including liver and cardiac transplantation, for much of South Africa. A significant number of patients with cirrhosis present for the first time at Groote Schuur Hospital with decompensation and a diagnosis of cirrhosis is made on the basis of association of signs of …
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Mechanical circulatory support in patients with severe heart failure
… in selected patients to bridge them to heart transplantation or recovery of heart function. MCS is manufactured in short-term or long-term designs. Short-term MCS can be coupled to an oxygenator to supply oxygen to the blood, and in that case also assist the lungs. Short-term MCS is most often …
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Pharmacokinetics and Effects on Blood Chemistry of Cyclosporine in Human Infants and Kid Goats
<p>Kid goats (newborn) have been used in transplantation protocols to study the techniques and problems of infant human cardiac transplantation. Immunosuppression has been by cyclosporine in both species. However, the pharmacokinetics of cyclosporine (CSA) in both the kid goat and human infant were …
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Cardiac Organogenesis: 3D Bioscaffolds, Bioenergetics and Regeneration
Each year the Organ Procurement and Transplantation Network (OPTN) reports an increase in patients requiring an organ transplant without an increase in available donor organs, leading to a transplant gap that continues to widen. Over 70% of donor hearts are deemed unsuitable for transplantation …
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Estrogene verzögern die Entwicklung der Transplantatvaskulopathie nach Herztransplantation - Experimentelle Untersuchungen im Kleintiermodell
Die Herztransplantation stellt heute oftmals die einzig effektive Therapie für Patienten mit Herzerkrankungen im Endstadium dar (Meiser et al., 1997). Seit dem routinemäßigen Einsatz von Cyclosporin A kann die akute Abstoßung besser kontrolliert werden. Die chronische Abstoßung, die sich bereits …
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Untersuchungen zur Herztransplantation im Langzeitmodell am Schwein und chirurgische Aspekte zur Xenotransplantation des Schweineherzens
Hintergrund: (I) Ein Modell zur Herztransplantation (HTx) am Schwein im Langzeitversuch ist notwendig, um Fragen zur Myokardprotektion, zur post-OP eingeschränkten Myokardfunktion und zu Spätkomplikationen beantworten zu können. <br>(II) Bisher war unklar, ob anatomische Unterschiede zwischen …