Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"cardiac tissue engineering"”.
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Cardiac tissue engineering : bioreactor cultivation parameters
Tissue engineering may be useful in fighting heart disease since it offers the possibility of creating functional tissue equivalents for scientific studies and tissue repair. In the present work, we examined how variations in cultivation parameters of a model tissue engineering system influenced …
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Biomimetic approach to cardiac tissue engineering
… Finally, in order to mimic capillary structure cardiac fibroblasts and myocytes were co-cultured on a scaffold with a parallel channel array that was perfused with culture medium supplemented with synthetic oxygen carrier (PFC emulsion). Presence of the PFC emulsion resulted in significantly …
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Biomimetic electrical stimulation for cardiac tissue engineering
A major challenge of tissue engineering is directing cells to establish the physiological structure and function of the tissue being replaced. Electrical stimulation has been used to induce synchronous contractions of cultured cardiac constructs. The hypothesis adopted for this study is that …
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Biosynthesis of polyhydroxyalkanoates for cardiac tissue engineering applications
As a result of the enormous clinical need, cardiac tissue engineering has become a prime focus of research within the field of tissue engineering. In this project, Poly(3- hydroxyoctanoate), P(3HO), a medium chain length (mcl-PHAs) biodegradable, biocompatible and elastomeric polyhydroxyalkanoate, …
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Bioreactors and microbioreactors for electromechanical stimulation in cardiac tissue engineering
… culture systems for laboratory studies of cardiac tissue engineering, featuring controlled electrical, or combined electro-mechanical stimulation of the culture environment. In consideration of the different research interests involved at the diverse hierarchical levels,the work was …
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Collagen scaffolds and injectable biopolymer gels for cardiac tissue engineering
… begun to shown promise for cell delivery for cardiac tissue engineering. Although various polymers and material forms have been explored, there is a need for: injectable gels that meet certain design specifications; a more indepth characterization of the scaffold properties; and a deeper …
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Production and Characterisation of Tissue-mimicking Collagen Scaffolds for Cardiac Tissue Engineering
The ideal scaffold for tissue engineering provides an architecture similar to natural tissue. For cardiac tissue repair, this three dimensional environment can be modelled on the myocardial extracellular matrix (ECM). To approximate the material composition of the ECM, collagen type I can be used, …
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Development of cardiac patches using medium chain length polyhydroxyalkanoates for cardiac tissue engineering
… that make them exceptional for applications in cardiac tissue engineering. Cardiovascular diseases (CVD) are a major cause of death worldwide. Cardiac patches aim to facilitate the normal functioning of the heart muscle by providing repair and support to the infarcted tissue post myocardial …
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Engineered hydrogels with biomimetic biochemical and physical signaling cues for cardiac tissue engineering
L'abstract è presente nell'allegato / the abstract is in the attachment
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Preparation and Characterization of Electrospun rGO-Poly(ester amide) Tissue Engineering Scaffolds
Tissue engineering scaffolds should support tissue maturation through exposure to biologically relevant stimuli and through successful cell infiltration. External electrical stimulation is particularly relevant for cardiac and neural applications, and requires conductive scaffolds to propagate …
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Collagen-Glycosaminoglycan Scaffold Systems to Assess HL-1 Cardiomyocyte Beating and Alignment
… heart attacks occurring annually, the need for tissue-engineered strategies to regenerate damaged cardiac tissue has become increasingly important. This thesis discusses the development of scaffold systems to examine the alignment and beating potential of HL-1 cardiomyoctyes in a 3D environment. …
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Cardiac organoid technology and computational processing of cardiac physiology for advanced drug screening applications
… and drug screening. This is especially true for tissues that are difficult to study due to tissue sensitivity and limited regenerative capacity, such as the heart. Previous work in stem cell-derived cardiac tissue has exploited how we can engineer biologically functional heart tissue by providing …
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A 3-dimensional vascularized cardiac tri-culture model using chitosan nanofiber scaffolds
The development of an in vitro tissue model that can mimic the 3-dimenisonal (3-D) cellular architecture and mosaic of myocardial tissue holds great value for cardiac tissue engineering, modeling, and cardiovascular drug screening applications. The main objective of this project was to develop a …
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Design, Production and Characterisation of Anisotropic Collagen Scaffolds for Cardiac Tissue Repair
… heart muscle wall contributes significantly to cardiac function. Recapitulating this complex structure *in vitro* is challenging and there has been limited success achieving this in tissue engineering scaffolds. Unidirectional ice-templating has been established in prior work and collagen …
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Development of a Tubular Biological Tissue-Engineered Heart Valve with Growth Potential
This thesis investigates tissue-engineered cardiovascular devices for pediatric patients and their function and growth potential in preclinical testing. Specifically, engineered tissue tubes were fabricated by entrapping dermal fibroblasts in a fibrin gel and allowing them to replace it with …
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Architectural control of ice-templated collagen scaffolds for cardiac regeneration
… to produce biomimetic scaffolds to facilitate cardiac tissue regeneration. Ice-templated collagen scaffolds have demonstrated translational success in other clinical applications. The ice templating technique utilizes phase separation dynamics during solidification and subsequent sublimation of …
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Electrospun scaffolds incorporating nanoparticles for controlled drug delivery in post-infarction cardiac repair
L'abstract è presente nell'allegato / the abstract is in the attachment