Global ETD Search
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Showing 1 to 10 of 10 for “"cardiac stem cells"”.
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Keratose Hydrogels Promote Vascular Smooth Muscle Differentiation from c-kit+ Human Cardiac Stem Cells: Underlying Mechanism and Therapeutic Potential
… severely limit this therapy. C-kit+ human cardiac stem cells (hCSCs) offers a viable alternative therapy to treat cardiovascular disease by replacing damaged cardiac tissue; however, low cell viability, low retention/engraftment, and uncontrollable in vivo differentiation after …
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Blood plasma-mediated effects on regenerative features of a novel adult human cardiac stem cell population
… relies on the functionality of endogenous adult stem cell populations found in various organs including the heart, a complex interaction with systemic factors carried by the blood is evident. Thus, young blood or blood products are increasingly recognized as potential therapeutic agents to target …
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Stem cells in the adult heart - 3D culture, isolation of side population cells and search for a stem cell niche
Cardiac tissue shows a poor regenerative capacity. From 2003 reports, mostly based on animal models, have showed existence of stem cells also in the heart. Using 14C measurements, a slow but steady turnover of the cardiac cells was shown in humans, around 1%/year. As a source for this regeneration …
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Transcriptional profile of c-kit positive cardiac stem-progenitor cells (c-kitpos eCSCs) isolated from the four chambers of the adult human heart
… harbours a population of resident (endogenous) cardiac stem cells (eCSCs). They express the stem cell factor receptor c-kit, are distributed throughout the myocardium, are clonogenic, self-renewing and multi-potent, in that they differentiate into the 3 main cardiac lineages; cardiomyocytes, …
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Proepicardial Cell Differentiation During Cardiac Development
<p> Epicardial cells have an emerging role as cardiac stem cells. These cells and their progenitors, proepicardial (PE) cells, have been recently shown to give rise to all resident cell types in the heart. The contribution of PE-derived cells to the development of atrioventricular (AV) valves and …
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Stem Cells as a therapy for myocardial infarction in animal models
Advances in stem cell biology have challenged the notion that infarcted myocardium is irreparable. The pluripotent ability of stem cells to differentiate into specialized cell lines began to garner intense interest within cardiology when it was shown in animal models that intramyocardial injection …
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Relevanz der humanen Xylosyltransferase-I in der Seneszenz-assoziierten Gewebe-Remodellierung und der adulten Knochenhomöostase
… induction of acute senescence in human cardiac stem cells (hCSCs) caused neither XT-I regulation. However, a senescence-associated secretory phenotype (SASP)-mediated induction of XT-I gene expression and activity along with an expression increase of ECM-associated proteins was …
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Development and application of a microfluidic platform for single-cell cultivation of CHO suspension cell lines
… Predominantly, Chinese hamster ovary (CHO) cells are utilized in these bioproduction processes, as they can easily be genetically modified and thereby are able to express biopharmaceuticals that are human-compatible, are well-established in industrial-scale cultivation, and achieve high …
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Materials and Nanostructured Coatings for Soft Tissue Regeneration
… common causes of death in Western countries. Cardiac Regenerative Medicine appears to be a promising alternative to pharmacologic treatment or organ transplantation although cellular therapies based on progenitor cell injection are still problematic. Myocardial Tissue Engineering (MTE) is a …
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TIMP-1 Activates a Unique Cardiac Stem Cell Population, CD63+ve/C-KIT+ve, Thereby Enhancing Cardiac Differentiation, and Protects the Heart From Adverse Cardiac Remodeling Following Myocardial Infarction
We previously demonstrated that embryonic stem (ES) cells over-expressing tissue inhibitor of metalloproteinase-1 (TIMP-1) have increased potential to engraft and differentiate into cardiac myocytes following transplantation into the infarcted heart. However, the ability of TIMP-1 to activate …