Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"cardiac remodelling"”.
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Biomechanics of Cardiac Remodelling in Heart Failure
Heart failure (HF) occurs when cardiac output does not meet the requirements of the body. HF is the result of maladaptive cardiac remodelling that alters myocardial structure and ventricular function. Current HF treatments were developed targeting patients with systolic dysfunction, but these …
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PIEZO1 Channel-Mediated Mechanotransduction as a Driver of Cardiac Remodelling
… overload is a central driver of pathological cardiac hypertrophy and fibrosis, yet the mechanism linking mechanical cues to adverse remodelling remains unclear. Fibroblasts are major effector cells of fibrotic remodelling. Still, the precise mechanism by which fibroblasts decode biomechanical …
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Pathophysiological role of aldosterone in cardiac remodelling after myocardial infarction
… a stabilising mechanism to maintain the cardiac output but over time becoming maladaptive and leading to progressive ventricular dilatation, dysfunction, HF and premature death. This process is termed remodelling. It is now understood that a complex series of mechanical, genetic and …
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Control of Cardiac Remodelling during Ageing and Disease by Epigenetic Modifications and Modifiers
… physiological, morphological and biochemical remodelling. Pivotal to the age-associated alterations in cardiac phenotype is a decline in the proliferative capacity of cardiac myocytes (CMs), which is insufficient to compensate for the basal rate of CM death over time. The terminally …
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The impact of diabetes on cardiac remodelling after myocardial infarction: potential role of thyroid hormone signalling
… infarction and deteriorates post-ischaemic cardiac remodelling. This study investigated possible implications of thyroid hormone (TH) signalling in either reducing or preventing this response. TH signalling has a regulatory role in metabolism, cardiac function, growth and ischaemic stress. …
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Targeting macrophages GLP-1 receptor pathways as emerging therapies to ameliorate cardiac remodelling associated with diabetes
… as a hallmark of diabetes, induces cardiac abnormalities specifically associated with inflammation, extracellular matrix (ECM) changes, and diastolic dysfunction, which accelerate heart failure development and progression. Despite active control of blood glucose and cardiovascular …
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A study on the role of oxidative stress and protein kinase signalling in hyperglycaemia induced cardiac remodelling
… leads to a maladaptation called pathological cardiac remodelling and occurs via oxidative stress due to excess production of reactive oxygen species (ROS). In the heart, ROS modulates cardiac differentiation, cardiomyocyte proliferation, and myocardial tissue growth via ROS-sensitive protein …
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A tri-phasic continuum model for the numerical analysis of biological tissue proliferation using the Theory of Porous Media. Application to cardiac remodelling in rheumatic heart disease
… (TPM) can represent the proliferative growth and remodelling processes related to RHD within a thermodynamically consistent framework and is additionally advantageous with application to biological tissue due to the ability to couple multiple constituents, such as tissue and blood. The research …
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Investigating the effects of enhanced catecholamine stimulation in stem cell-derived cardiomyocytes
… Autonomic imbalance, marked by an exaggerated cardiac sympathetic tone and parasympathetic withdrawal, is a prominent characteristic of heart failure. As the atrial and ventricular pumping efficiency declines, this sympatho-overexcitation induces a compensatory stress response known as cardiac …
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Studies to determine the mechanisms of the anti-atherosclerotic effects of eicosapentaenoic acid: possible role for endocannabinoids?
… was associated with endothelial dysfunction, cardiac remodelling, and significantly elevated anandamide (AEA) and 2-AG levels in brain, heart and aortic tissues. Supplementation of the atherogenic diet with the EPA, while having a negligible impact on endothelial dysfunction or cardiac …
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EFFECTS OF DAPAGLIFLOZIN ON EXERCISE CAPACITY, RESPIRATORY FUNCTION, BIOMARKERS, SLEEP APNEA, AND LEFT VENTRICULAR REMODELING IN PATIENTS WITH HEART FAILURE: A PROSPECTIVE, SINGLE CENTER, NON RANDOMIZED STUDY
… The first focused on exercise capacity, cardiac remodelling, fluid status, and conventional biomarkers. The second investigated alveolar-capillary membrane function through surfactant protein-B (proSP-B), gas exchange, and sleep-disordered breathing. Evaluations were performed at …
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Biomarkers of ventricular remodelling in African hypertensives.
… effects of long standing hypertension on cardiac remodelling which ultimately lead to systolic and diastolic dysfunctions as this affects the prognosis, management and treatment modalities of hypertension. We studied 210 subjects who were subdivided into three groups after …
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Exercise & cardiopulmonary physiology in rheumatoid arthritis
… morbidity and mortality risk from developing cardiac and pulmonary disorders than the general population, primarily due to a sedentary lifestyle. Aims: This project aimed to (1) obtain information on the rheumatic and musculoskeletal disease (RMD) patents’ achieved/preferred exercise …
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Myocardial creatine metabolism in experimental infarction and heart failure
… these changes are usually defined as pathologic remodelling. An important part of this negative remodelling process is disturbances in the myocardial energy metabolism. It has been demonstrated both in clinical and experimental studies that the failing heart contains low levels of creatine(Cr), …
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Investigating the protective role of the natural hormone Melatonin, in reducing drug-induced cardiotoxicity in the therapy of chronic diseases
… mostly unresolved but involves interplay between cardiac structural and electrical remodelling, metabolic alterations, cell death and altered gene expression. Mitochondrial dysfunction and HF are common complications of chronic treatment from diverse groups of drugs, in particular anticancer drugs …
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Characterisation of clinical and anatomical substrates in risk stratification and management of atrial fibrillation and ischaemic stroke
… between novel clinical and structural cardiac factors and their association with disease progression and development of adverse cardiovascular outcomes in patients with non-valvular atrial fibrillation. Towards this end, three articles in this thesis evaluate a cohort of hospitalised …
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Cardiac hypertrophy and the dynamic changes in structure and function after pressure overload
Introduction: Cardiac hypertrophy establishes itself when the heart has to pump against an increased resistance in the vasculature. Contrary to exercise-induced hypertrophy, pathological hypertrophy is characterized by an increased amount of interstitial collagen, induction of foetal-type genes, …
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Endothelial NADPH oxidases as regulators of coronary microvascular dysfunction in diabetic cardiac remodeling
… rate of 1.1 mg/kg/day to exacerbate the diabetic cardiac remodelling phenotype. Echocardiography was performed at three and six months of age to identify changes in cardiac structure and function. Assessment of left ventricular (LV) gene and protein expression (qRT-PCR and Western blot), fibrosis …
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Advanced in vivo imaging of the interactions between vascular and renal development in the zebrafish pronephric kidney
… this relationship are not fully understood. Cardiac remodelling resulting from disease is partly caused by the reactivation of developmental programmes. By unravelling the mechanisms that drive kidney development and function, it may be possible to gain novel insight into remodelled kidney …
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Exercise-Associated Cardiac Rhythm Disorders in Thoroughbred Racehorses
Cardiac arrhythmias negatively impact horseracing through concerns for horse and jockey safety and welfare. The most clinically relevant rhythm disorders in Thoroughbred racehorses (TBs) are atrial fibrillation (AF), which typically causes poor performance, and fatal arrhythmias which precipitate …
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