Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"cardiac remodeling"”.
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Integrins and SPARC : potential implications for cardiac remodeling
Der enorme Umbau des Herzgewebes, wie man ihn nach Drucküberlastung des Ventrikels oder MyokardInfarkt beobachten kann, gilt als eine der kausalen Ursachen des Herzversagens. Die Veränderungen in der Architektur des Herzens beeinflussen die mechanischen Eigenschaften des Herzmuskels, begründet sind …
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Role of the Endocannabinoid System in Cardiac Remodeling
… cannabinoid receptors have been implicated in cardiac remodeling with CB1 inhibition and CB2 activation reported to be beneficial. However, the role of these receptors in cardiac remodeling secondary to hypertension is not known. Moreover, the functions of the CB1 and CB2 cannabinoid receptors …
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Characterisation of cardiac remodeling associated with pregnancy: providing insights to peripartum cardiomyopathy
… However, pregnancy can induce adverse cardiac events in previously healthy women without any known cardiovascular disease. Understanding of the maternal cardiovascular adaptation during healthy pregnancy is important to identify deviations from regular patterns caused by pathological …
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Endothelial NADPH oxidases as regulators of coronary microvascular dysfunction in diabetic cardiac remodeling
… rate of 1.1 mg/kg/day to exacerbate the diabetic cardiac remodelling phenotype. Echocardiography was performed at three and six months of age to identify changes in cardiac structure and function. Assessment of left ventricular (LV) gene and protein expression (qRT-PCR and Western blot), fibrosis …
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The Efficacy Of Prostaglandin Synthase Inhibition On Attenuating Pressure Overload Induced Cardiac Remodeling
… has long been known to cause left ventricular remodeling. Although previous studies pointed towards inflammation as the pathological driver of cardiac remodeling, the exact mechanistic pathway associated with pressure overload-induced cardiac remodeling remains to be elucidated. In order to …
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The Role of Angiotensin-(1-7) in the Modulation of Angiotensin II-Dependent Cardiac Remodeling
Cardiac remodeling with associated changes in myocardial structure and function occurs in response to injury to the heart concomitant with chronic hypertension. The structural changes to the heart, including myocyte and vascular hypertrophy as well as interstitial and perivascular fibrosis, are …
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Mechanisms and Functional Consequences of Cardiac Remodeling: Role of Myocardial Rac1 and Vascular Profilin1 Genes
… of myocardial human Rac1 in the development of cardiac remodeling and heart failure in both animal and human patients. However, nothing is known about the effects of nonmammalian Rac protein on the mammalian heart. In an exciting discovery, we showed in chapter 2 of this thesis that a …
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A MECHANISM FOR CORTICAL BONE STEM CELL-DERIVED EXOSOMES’ THERAPEUTIC EFFECT ON POST-MYOCARDIAL INFARCTION REPERFUSION INJURY AND CARDIAC REMODELING
… Myocardial infarction (MI) is followed by cardiac remodeling involving extensive fibrosis and which can ultimately progress into heart failure. Previous studies have shown both that both post-MI and post-ischemia reperfusion (I/R), there is a reduction in scar size and improved cardiac …
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Characterization Of Pregnancy Induced Cardiac Hypertrophy In Rats
… compensate for fetal development, resulting in cardiac hypertrophy. For the majority of women, this physiological cardiac hypertrophy resolves following pregnancy. Prolonged cardiac hypertrophy can lead to heart failure. We propose that by studying the biochemical mechanisms that mediate healthy …
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TIMP-1 Activates a Unique Cardiac Stem Cell Population, CD63+ve/C-KIT+ve, Thereby Enhancing Cardiac Differentiation, and Protects the Heart From Adverse Cardiac Remodeling Following Myocardial Infarction
… potential to engraft and differentiate into cardiac myocytes following transplantation into the infarcted heart. However, the ability of TIMP-1 to activate endogenous stem cells and enhance their differentiation into cardiac regenerative cell types is still unknown. We postulate that TIMP-1 …
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Regulation Of The Tubulin Code In Cardiac Hypertrophy And Failure
… microtubule network underlies cellular growth in cardiac hypertrophy and contributes to contractile dysfunction in heart failure. Yet how the heart achieves this modified network is poorly understood. Determining how the “tubulin code” – the permutations of tubulin isoforms and post-translational …
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Innate Immune Transcription Activator Interferon Regulatory Factor-3 (IRF3) Contributes to Maladaptive Remodeling Post-myocardial Infarction
… in the developed world today. In fact, the remodeling process, which follows the initial ischemic episode of MI, is a major determinant of heart failure. Although several key mechanistic pathways involving cell growth and death have been identified, there is limited knowledge surrounding the …
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FUNCTIONAL, STRUCTURAL, CELLULAR, AND MOLECULAR CARDIAC RESPONSES IN NONHUMAN PRIMATE MODELS OF MENOPAUSE AND RADIATION EXPOSURE
… exposure are gaining attention as drivers of cardiac remodeling leading to heart failure, particularly heart failure with preserved ejection fraction (HFpEF). Myocardial fibrosis appears to be a shared pathologic feature of both conditions, but the underlying mechanism(s) and end stage results …
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The Role of FGF Signaling in the Regulation of Adult Murine Cardiomyocyte Contractility and Pathologic Hypertrophy
… strain on the heart, resulting in an ongoing remodeling process that initially maintains cardiac function, but ultimately becomes maladaptive. The signaling pathways that drive cardiac remodeling are extremely complex and poorly understood, and therefore, a better understanding of the …
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Modulation of mitogenic signaling and growth by sympathetic adrenergic regulation
… United States. Both diseases are associated with cardiac remodeling, including cellular growth and fibrosis. Central to the progression of heart disease and diabetes are the adrenergic receptors (ARs) and insulin receptors (IR), respectively. Classically considered to elicit separate, and even …
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Phosphorylation kinetics of cardiac gap junction regulation during stress
… disc to facilitate cellular coupling. Cardiac pathologies frequently manifest with disrupted gap junctional intercellular communication which can generate potentially fatal arrhythmias, thus, it is essential to elucidate mechanisms underlying Cx43 regulation and altered intercellular …
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The Transcription Factor TFEB Protects Against Cardiac Hypertrophy by Increasing Lysosomal Capacity and Activating AMPKα
… in most forms of heart disease. Pathological cardiac remodeling is a hallmark of impending heart failure. Lysosome-assisted processes such as autophagy and mitophagy play important roles in this remodeling, as do signaling pathways associated with the lysosome, such as AMPK and mTOR, a …
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Multifunctional Regulators of Cardiac Disease and Development
… In this thesis, I present my findings on two cardiac transcription factors MEF2 and Yap that play multiple roles in development. First, I show a novel function of myocyte enhancer factor 2 (MEF2) transcription factors in development of endochondral bone. MEF2 proteins are widely known as …
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Elucidating the role of LARP6 in cardiovascular remodeling
… treatments and therapeutics. Of note, structural remodeling of the heart precedes the onset of overt symptoms that diminish a patient's quality of life. Many factors contribute to the adverse remodeling and dysfunction observed in heart failure. Of note, obesity, excess sympathetic drive, elevated …
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